Anti-Periodontitis Effect of Symbiotic Fermented Seaweed Extract
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: Various natural products with antibacterial and anti-inflammatory properties have attracted considerable interest for the prevention and treatment of human diseases, including periodontal diseases. This study aimed to assess the anti-inflammatory effect of Laminaria japonica fermented extract (LJFE) by its ability to inhibit periodontitis in a mouse model of lipopolysaccharide (LPS)-induced inflammation. Methods: Laminaria japonica was fermented using Saccharomyces cerevisiae and Lactobacillus plantarum and its extract(LJFE) was evaluated for inhibitory activity against (LPS)induced periodontitis in mice. Results: The mechanisms of action of the anti-inflammatory and periodontitis inhibiting effects were revealed as the inhibition of inflammation-regulating proteins (iNOS) and cyclooxygenase-2(COX-2) and nuclear factor kappa B(NF-κB) DNA-binding activity. Conclusions: LJFE exhibits considerable potential as a treatment against pro-inflammatory cytokines.
Abstract
Objectives: Various natural products with antibacterial and anti-inflammatory properties have attracted considerable interest for the prevention and treatment of human diseases, including periodontal diseases. This study aimed to assess the anti-inflammatory effect of Laminaria japonica fermented extract (LJFE) by its ability to inhibit periodontitis in a mouse model of lipopolysaccharide (LPS)-induced inflammation. Methods: Laminaria japonica was fermented using Saccharomyces cerevisiae and Lactobacillus plantarum and its extract(LJFE) was evaluated for inhibitory activity against (LPS)induced periodontitis in mice. Results: The mechanisms of action of the anti-inflammatory and periodontitis inhibiting effects were revealed as the inhibition of inflammation-regulating proteins (iNOS) and cyclooxygenase-2(COX-2) and nuclear factor kappa B(NF-κB) DNA-binding activity. Conclusions: LJFE exhibits considerable potential as a treatment against pro-inflammatory cytokines.
참고문헌 (27)
- AbiodunO Arigbede, "Periodontitis and systemic diseases: A literature review", Journal of Indian Society of Periodontology, 16(4), pp.487~ (2012), Medknow[DOI]
- Joan Otomo-Corgel, "State of the Science: Chronic Periodontitis and Systemic Health", Journal of Evidence Based Dental Practice, 12(3), pp.20~28 (2012), Elsevier BV[DOI]
- M. Ide, "Periodontitis, cardiovascular disease and pregnancy outcome – focal infection revisited?", British Dental Journal, 217(8), pp.467~474 (2014), Springer Science and Business Media LLC[DOI]
- Bruce L Pihlstrom, "Periodontal diseases", The Lancet, 366(9499), pp.1809~1820 (2005), Elsevier BV[DOI]
- Martin A. Taubman, "Immune Response: The Key to Bone Resorption in Periodontal Disease", Journal of Periodontology, 76(11S), pp.2033~2041 (2005), Wiley[DOI]
- M.A. Taubman, "Involvement of T-Lymphocytes in Periodontal Disease and in Direct and Indirect Induction of Bone Resorption", Critical Reviews in Oral Biology & Medicine, 12(2), pp.125~135 (2001), SAGE Publications[DOI]
- Mikihito Kajiya, "Role of periodontal pathogenic bacteria in RANKL-mediated bone destruction in periodontal disease", Journal of Oral Microbiology, 2(1), pp.5532~ (2010), Informa UK Limited[DOI]
- David E. Deas, "Response of chronic and aggressive periodontitis to treatment", Periodontology 2000, 53(1), pp.154~166 (2010), Wiley[DOI]
- Pirkko Pussinen, "Serum Microbial- and Host-Derived Markers of Periodontal Diseases: A Review", Current Medicinal Chemistry, 14(22), pp.2402~2412 (2007), Bentham Science Publishers Ltd.[DOI]
- Hulya Toker, "N‐Acetylcysteine, a Thiol Antioxidant, Decreases Alveolar Bone Loss in Experimental Periodontitis in Rats", Journal of Periodontology, 80(4), pp.672~678 (2009), Wiley[DOI]
- Mayuka Nakajima, "Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice", BMC Complementary and Alternative Medicine, 16(1) (2016), Springer Science and Business Media LLC[DOI]
- Lamprini Karygianni, "Natural Antimicrobials and Oral Microorganisms: A Systematic Review on Herbal Interventions for the Eradication of Multispecies Oral Biofilms", Frontiers in Microbiology, 6(1), pp.1529~ (2016), Frontiers Media SA[DOI]
- Veronica Lazar, "Periodontitis and Periodontal Disease - Innovative Strategies for Reversing the Chronic Infectious and Inflammatory Condition by Natural Products", Current Pharmaceutical Design, 22(2), pp.230~237 (2015), Bentham Science Publishers Ltd.[DOI]
- J. S. Choi, "Inhibition of oral pathogens and collagenase activity by seaweed extracts", Journal Environment Biology, 33(1), pp.121~ (2012)
- Han-Bin Cho, "Clinical and Microbial Evaluation of the Effects on Gingivitis of a Mouth Rinse Containing an Enteromorpha linza Extract", Journal of Medicinal Food, 14(12), pp.1670~1676 (2011), 한국식품영양과학회
- Jisang Park, "Fucoidan inhibits LPS-induced inflammation in vitro and during the acute response in vivo", International Immunopharmacology, 43, pp.91~98 (2017), Elsevier BV[DOI]
- KALU KAPUGE ASANKA SANJEEWA, "Anti-inflammatory activity of a sulfated polysaccharide isolated from an enzymatic digest of brown seaweed Sargassum horneri in RAW 264.7 cells", Nutrition Research and Practice, 11(1), pp.3~10 (2017), 한국영양학회
- ChengHan Mei, "Antitumor Effects of Laminaria Extract Fucoxanthin on Lung Cancer", Marine Drugs, 15(2), pp.39~ (2017), MDPI AG[DOI]
- Thamaraiselvan Rengarajan, "Cancer Preventive Efficacy of Marine Carotenoid Fucoxanthin: Cell Cycle Arrest and Apoptosis", Nutrients, 5(12), pp.4978~4989 (2013), MDPI AG[DOI]
- Qingwen Zhu, "Antitumor activity of polysaccharide from Laminaria japonica on mice bearing H22 liver cancer", International Journal of Biological Macromolecules, 92, pp.156~158 (2016), Elsevier BV[DOI]
- Yin-guang Cao, "Antiviral activity of polysaccharide extract from Laminaria japonica against respiratory syncytial virus", Biomedicine & Pharmacotherapy, 84, pp.1705~1710 (2016), Elsevier BV[DOI]
- Albana Cumashi, "A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds", Glycobiology, 17(5), pp.541~552 (2007), Oxford University Press (OUP)[DOI]
- Nakkarike M. Sachindra, "Radical Scavenging and Singlet Oxygen Quenching Activity of Marine Carotenoid Fucoxanthin and Its Metabolites", Journal of Agricultural and Food Chemistry, 55(21), pp.8516~8522 (2007), American Chemical Society (ACS)[DOI]
- Longyuan Hu, "Polysaccharide Extracted from Laminaria japonica Delays Intrinsic Skin Aging in Mice", Evidence-Based Complementary and Alternative Medicine, 2016, pp.1~8 (2016), Hindawi Limited[DOI]
- Nagatoshi Fujiwara, "Macrophages in Inflammation", Current Drug Target -Inflammation & Allergy, 4(3), pp.281~286 (2005), Bentham Science Publishers Ltd.[DOI]
- 정해영, "노화과정에서 분자염증 반응과 에너지 대사의 중요성", 대한암예방학회지, 10(1), pp.6~17 (2005), 대한암예방학회
- 이효승, "마우스 대식세포에서 血竭(Draconis Resina)의 항산화 및 항염증 효과", 대한본초학회지, 23(2), pp.179~192 (2008), 대한본초학회