Dexamethasone-SMEDDS가 담지된 콘택트렌즈의 개발 및 평가
Development and Evaluation of Dexamethasone-SMEDDS loaded Contact Lenses
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초록
본 연구의 목적은 Dexamethasone-SMEDDS를 함유한 콘택트렌즈를 개발하여 덱사메타손의 용해도 및 생체이용률을 증가시켜 결막염, 각막염 등의 염증 치료를 위한 안구 전달 시스템을 제공하는 것이다. 덱사메타손에 대한 용해도와 혼화성을 통해 Capryol® 90(Oil)과 Transcutol HP(Co-surfactant)가 선정되었고 추가적으로 Cloud Point 측정 실험을 통해 PEG 200(Surfactant)이 선정되었다. Surfactant와 Co-surfactant의 비율을 1:1, 1:2, 2:1로 달리하여 3상 평형도를 작성하였고 Emulsion형성 범위가 가장 넓은 1:2 비율을 선택하였다. 콘택트렌즈는 가장 기본이 되는 HEMA, EGDMA, AIBN을 사용한 HEMA hydrogel Contact lens를 제조하였다. Oil의 양을 달리하여 평가하였을 때 많이 들어간 콘택트렌즈의 함수율 및 젖음성이 좋아 착용감에 용이하다 판단하였고, 용출평가를 통해 약물이 6시간동안 지속적으로 방출됨을 보아 점안액에 비해 서방형 방출을 유도해 생체이용률을 향상시킬 수 있다고 판단하였다.
Abstract
The purpose of this study is to develop a contact lens containing Dexamethasone-SMEDDS to increase the solubility and bioavailability of dexamethasone to provide an ocular delivery system for the treatment of inflammation such as conjunctivitis and keratitis. Capryol® 90 (Oil) and Transcutol HP (Co-surfactant) were selected through solubility and miscibility in dexamethasone, and PEG 200 (surfactant) was additionally selected through Cloud Point measurement experiments. A three-phase equilibrium diagram was created by varying the ratio of Surfactant and Co-surfactant to 1:1, 1:2, and 2:1, and the ratio of 1:2, which has the widest range of Emulsion formation, was selected. Contact lenses were manufactured with HEMA hydrogel contacts using HEMA, EGDMA, and AIBN, which are the most basic. When evaluated differently in the amount of oil, the moisture content and wettability of the contact lenses that have been put in a lot are good for wearing, and the elution evaluation showed that the drug was continuously released for 6 hours, which could improve bioavailability by inducing western release compared to ophthalmic solutions.
참고문헌 (10)
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