The Increasing Frequency of Cervical Cancer in Korean Women under 35
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Purpose: The goal of this study was to determine the clinical and epidemiological trends of cervical cancer in young Korean women. Social behavior including sexual habits has changed in Korean women, with sexual activity commencing at a younger age. These changes are likely to influence certain risk factors of cervical cancer, resulting in changing trends in the occurrence of the disease. Materials and Methods: The incidence of cervical cancer in women less than 35 years-old between January 1990 and December 2006 was analyzed, and available medical records from January 1996 to December 2006 were reviewed. The clinical, pathological and epidemiologic characteristics and changing trends among these young patients were analyzed. Results: Over the last two decades, the incidence of young (＜ 35 years) cervical cancer patients increased, more patients had an aggressive form of the disease, and there was a higher rate of women with more advanced education. Human papillomavirus (HPV) infection was detected in 94.0% of the women (63/67) tested. HPV 16 (82.5%) and HPV 18 (12.7%) were the two most common viral infections detected throughout the study period. Conclusions: The changing trends and risk factors identified suggest a need for more active education of young women about cervical cancer prevention strategies. In addition, young women are strongly recommended to undergo a regular screening test and HPV vaccination. (Cancer Res Treat. 2008;40:1-5)
Abstract
Purpose: The goal of this study was to determine the clinical and epidemiological trends of cervical cancer in young Korean women. Social behavior including sexual habits has changed in Korean women, with sexual activity commencing at a younger age. These changes are likely to influence certain risk factors of cervical cancer, resulting in changing trends in the occurrence of the disease. Materials and Methods: The incidence of cervical cancer in women less than 35 years-old between January 1990 and December 2006 was analyzed, and available medical records from January 1996 to December 2006 were reviewed. The clinical, pathological and epidemiologic characteristics and changing trends among these young patients were analyzed. Results: Over the last two decades, the incidence of young (＜ 35 years) cervical cancer patients increased, more patients had an aggressive form of the disease, and there was a higher rate of women with more advanced education. Human papillomavirus (HPV) infection was detected in 94.0% of the women (63/67) tested. HPV 16 (82.5%) and HPV 18 (12.7%) were the two most common viral infections detected throughout the study period. Conclusions: The changing trends and risk factors identified suggest a need for more active education of young women about cervical cancer prevention strategies. In addition, young women are strongly recommended to undergo a regular screening test and HPV vaccination. (Cancer Res Treat. 2008;40:1-5)
참고문헌 (25)
- 이효표, "한국 부인암 등록 사업 조사 보고서: 수정본(2002. 1. 1-2002. 12. 31)", 대한산부인과학회지, 45(5), pp.1029~70 (2005), 대한산부인과학회
- 곽민선, "암 검진 수검에 영향을 주는 요인", 예방의학회지, 38(4), pp.473~481 (2005), 대한예방의학회
- Schiffman M., "The carcinogenicity of human papillomavirus types reflects viral evolution", Virology, 337, pp.76~84 (2005)
- 박종섭, "한국 젊은 여성의 성생활 양상; HPV예방 백신 도입을 위한 예비 연구", Journal of Gynecologic Oncology, 18(3), pp.209~218 (2007), 대한부인종양콜포스코피학회
- Quinn MA, "Carcinoma of the cervix uteri", Int J Gynaecol Obstet, 95, pp.S43~103 (2006)
- Pecorelli S., "Cancer in women", Int J Gynaecol Obstet, 82, pp.369~79 (2003)
- Parkin DM, "Cancer in developing countries", Cancer Surv, 19, pp.519~61 (1994)
- Parkin DM, "Global cancer statistics", CA Cancer J Clin, 55, pp.74~108 (2005)
- Koutsky L., "Epidemiology of genital human papillomavirus infection", Am J Med, 102, pp.3~8 (1997)
- Woon-Won Jung, "Strategies Against Human Papillomavirus Infection and Cervical Cancer", The Journal of Microbiology, 42(4), pp.255~266 (2004), 한국미생물학회
- Park TC, "Human papillomavirus genotyping by the DNA chip in the cervical neoplasia", DNA Cell Biol, 23, pp.119~25 (2004)
- Bae, Jeong-Hoon, "Human Papillomavirus (HPV) Type Distribution in Korean Women: A Meta-Analysis", Journal of Microbiology and Biotechnology, 18(4), pp.788~794 (2008), 한국미생물·생명공학회
- Becker TM, "Sexually transmitted diseases and other risk factors for cervical dysplasia among southwestern Hispanic and non-Hispanic white women", JAMA, 271, pp.1181~8 (1994)
- Shin HR, "Prevalence of human papillomavirus infection in women in Busan, South Korea", Int J Cancer, 103, pp.413~21 (2003)
- "International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for invasive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer. 2006;120:885-91", ~ (2006)
- Wellings K., "Sexual behavior in contest: a global perspective", Lancet, 368, pp.1706~28 (2006)
- Chung HH, "Cervical cancer incidence and survival in Korea : 1993-2002", Int J Gynecol Cancer, 16, pp.1833~8 (2006)
- Atahan IL, "Long-term outcome and prognostic factors in patients with cervical carcinoma: a retrospective study", Int J Gynecol Cancer, 17, pp.833~42 (2007)
- Kastritis E., "The impact of age in the outcome of patients with advanced or recurrent cervical cancer after platinumbased chemotherapy", Gynecol Oncol, 104, pp.372~6 (2000)
- Russell JM, "Cervical carcinoma: prognosis in younger patients", Br Med J, 295, pp.300~3 (1987)
- Mariani L., "Cervical carcinoma in young patients: clinical and pathological variables", Int J Gynaecol Obstet, 41, pp.61~6 (1993)
- Murrell DS, "Carcinoma of the cervix in women up to 35 year of age", Clinical Oncol, 2, pp.260~3 (1990)
- Elliott PM, "Changing character of cervical cancer in young women", BMJ, 298, pp.288~90 (1989)
- Vinh-Hung V., "Prognostic value of histopathology and trends in cervical cancer: a SEER population study", BMC Cancer, 7, pp.164~ (2007)
- Kirschner B., "Comparison of convertntional Papanicolaou smear and SurePath liquid-based cytology in the Copenhagen population screening programme for cervical cancer", Cytopathology, 17, pp.187~94 (2006)