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펄스 레이저 가공에 의한 마이크로 그루브 패턴이 골 세포 유착에 미치는 영향 분석

Analysis of the Effect of Micro-groove Patterns on Osseointegration using Pulsed Laser Processing

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초록

As the demand for biomaterials and medical devices increases due to advancements in medical technology and the rising average lifespan of the population, the importance of surface treatment technology for biometallic materials used in orthopedic implants is highlighted. Achieving stable mechanical attachment between the implant and human bone, specifically bone cell adhesion, is crucial. Without proper adhesion, issues such as inflammation and reduced load-bearing capacity can occur, leading to the need for implant reimplantation. Therefore, this paper focuses on creating a micro-groove pattern using a pulsed nanosecond laser on the surface of a titanium alloy (Ti6Al4V), a biometallic material, to promote cell adhesion. To evaluate the effectiveness of the pattern in enhancing cell adhesion, MG-63 osteoblasts were cultured on the micro-groove patterned surface, and their adhesion and morphological changes were analyzed. This study confirms the potential of laser processing as a surface treatment method for biometallic materials.

Abstract

As the demand for biomaterials and medical devices increases due to advancements in medical technology and the rising average lifespan of the population, the importance of surface treatment technology for biometallic materials used in orthopedic implants is highlighted. Achieving stable mechanical attachment between the implant and human bone, specifically bone cell adhesion, is crucial. Without proper adhesion, issues such as inflammation and reduced load-bearing capacity can occur, leading to the need for implant reimplantation. Therefore, this paper focuses on creating a micro-groove pattern using a pulsed nanosecond laser on the surface of a titanium alloy (Ti6Al4V), a biometallic material, to promote cell adhesion. To evaluate the effectiveness of the pattern in enhancing cell adhesion, MG-63 osteoblasts were cultured on the micro-groove patterned surface, and their adhesion and morphological changes were analyzed. This study confirms the potential of laser processing as a surface treatment method for biometallic materials.

참고문헌 (11)

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  7. Ozdemir M., "A new and emerging technology : Laser-induced surface modification of polymers", Trends in Food Science and Technology, 9, pp.159~167 (1998)
  8. Biggs, M. J., "Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330nm deep microgrooves", Journal of the Royal Society, Interface, 5(27), pp.1231~1242 (2008)
  9. Cipriano, A. F., "Bone marrow stromal cell adhesion and morphology on micro- and sub-micropatterned titanium", Journal of biomedical nanotechnology, 10(4), pp.660~668 (2014)
  10. J. R. Park, "A study on the injection mold with superhydrophobic surface properties using nanosecond laser machining", Design & Manufacturing, 17(33), pp.48~54 (2023)
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