전자선 조사가 베타글루칸의 항알레르기 활성에 미치는 영향
Effect of Electron Beam Irradiation on the Anti-allergy Activity of β-Glucan
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This study evaluated the change in anti-allergy activity of β-glucan by electron beamirradiation. β-Glucan was irradiated at dose of 50 kGy and then orally pre-treated with electronbeam irradiated and non irradiated β-Glucan for 7 days. After pre-treatment, allergy was inducedby injection of ovalbumin (OVA). Serum total immunoglobulin E (IgE) and OVA-specific IgE levelsin the allergic mice was significantly increased but the mice pre-treated 50 kGy electron beam irradiatedβ-glucan was significantly decreased the levels of total IgE and OVA-specific IgE, respectively. Moreover, cytokine production (interleukin-4) was also decreased in the 50 kGy electronbeam irradiated β-Glucan pre-treated mice. These results indicate that pre-treatment of 50 kGyelectron beam irradiated β-glucan may elevate the anti-allergy activity. Therefore, electron beamirradiatedβ-glucan could be used for nutraceutical foods in food industry.
Abstract
This study evaluated the change in anti-allergy activity of β-glucan by electron beamirradiation. β-Glucan was irradiated at dose of 50 kGy and then orally pre-treated with electronbeam irradiated and non irradiated β-Glucan for 7 days. After pre-treatment, allergy was inducedby injection of ovalbumin (OVA). Serum total immunoglobulin E (IgE) and OVA-specific IgE levelsin the allergic mice was significantly increased but the mice pre-treated 50 kGy electron beam irradiatedβ-glucan was significantly decreased the levels of total IgE and OVA-specific IgE, respectively. Moreover, cytokine production (interleukin-4) was also decreased in the 50 kGy electronbeam irradiated β-Glucan pre-treated mice. These results indicate that pre-treatment of 50 kGyelectron beam irradiated β-glucan may elevate the anti-allergy activity. Therefore, electron beamirradiatedβ-glucan could be used for nutraceutical foods in food industry.
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