Development of Freeze-Dried DOTMP Kits for Labeling with 68Ga
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Lyophilized DOTMP kits were prepared using DOTMP, ammonium acetate, andascorbic acid. The 68Ga-DOT MP was prepared by incubating the kit dissolved in 0.5 ml ofconcentrated 68Ga using NaCl method and 0.5 ml of DDW, at 100°C for 7 min. The labeling yieldwas evaluated by two solvent systems of TLC. 1 MBq of concentrated 68Ga was labeled with 0.8μg of DOTMP by high radiolabeling yield (>98%), which was determined by two TLC methods. The composition of the prepared freeze-dried vial is 400 μg of DOTMP, 19.27 mg of ammoniumacetate and 17.62 mg of ascorbic acid. ~555 MBq of 68Ga-DOT MP was prepared with excellentradiochemical purity (>98%) and it was stable for 4 hr at room temperature. In conclusion,Freeze-dried DOTMP kits for the convenient preparation of 68Ga-DOTMP have been developed. Availability of this kit is expected to stimulate the widespread use of 68Ga-DOTMP in the fields ofnuclear medicine.
Abstract
Lyophilized DOTMP kits were prepared using DOTMP, ammonium acetate, andascorbic acid. The 68Ga-DOT MP was prepared by incubating the kit dissolved in 0.5 ml ofconcentrated 68Ga using NaCl method and 0.5 ml of DDW, at 100°C for 7 min. The labeling yieldwas evaluated by two solvent systems of TLC. 1 MBq of concentrated 68Ga was labeled with 0.8μg of DOTMP by high radiolabeling yield (>98%), which was determined by two TLC methods. The composition of the prepared freeze-dried vial is 400 μg of DOTMP, 19.27 mg of ammoniumacetate and 17.62 mg of ascorbic acid. ~555 MBq of 68Ga-DOT MP was prepared with excellentradiochemical purity (>98%) and it was stable for 4 hr at room temperature. In conclusion,Freeze-dried DOTMP kits for the convenient preparation of 68Ga-DOTMP have been developed. Availability of this kit is expected to stimulate the widespread use of 68Ga-DOTMP in the fields ofnuclear medicine.
참고문헌 (20)
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