Generator 컬럼용 68GeO2 합성 및 68Ga3+의 거동에 관한 연구
Study on Synthesis of 68GeO2 and Behavior of 68Ga3+ for Generator Column
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초록
68Ga has emerged as a promising candidate for non-invasive diagnostic imaging within Positron Emission Tomography (PET) because of its advantageous radiochemical characteristics (t1/2=68 min, β+ yield ~89%). 68Ga forms a stable chelation with various ligands and it is possible to be quickly and easily study using a 68Ge/68Ga generator. Commercial 68Ge/68Ga generators are chromatographic system using the inorganic materials such as alumina and tin dioxide which are employed as column matrixes for 68Ge. In this study, we tried out to make 68Ge/68Ga generator system with the 68GeO2 microstructures for column matrix. 68Ge tends to have stable bond with oxide as 68GeO2 microstructures. The 68GeO2 has been synthesized by hydrolysis of GeCl4 (sol-gel method) and characterized by X-ray diffraction and scanning electron microscope for geometrical analysis. The stability of GeO2 was tested using eluents with diverse solvents (water, ethanol and 0.1 N HCl). The radioactivity of 68Ga3+ in eluate through GeO2 was measured to prove a function as column material for a generator.
Abstract
68Ga has emerged as a promising candidate for non-invasive diagnostic imaging within Positron Emission Tomography (PET) because of its advantageous radiochemical characteristics (t1/2=68 min, β+ yield ~89%). 68Ga forms a stable chelation with various ligands and it is possible to be quickly and easily study using a 68Ge/68Ga generator. Commercial 68Ge/68Ga generators are chromatographic system using the inorganic materials such as alumina and tin dioxide which are employed as column matrixes for 68Ge. In this study, we tried out to make 68Ge/68Ga generator system with the 68GeO2 microstructures for column matrix. 68Ge tends to have stable bond with oxide as 68GeO2 microstructures. The 68GeO2 has been synthesized by hydrolysis of GeCl4 (sol-gel method) and characterized by X-ray diffraction and scanning electron microscope for geometrical analysis. The stability of GeO2 was tested using eluents with diverse solvents (water, ethanol and 0.1 N HCl). The radioactivity of 68Ga3+ in eluate through GeO2 was measured to prove a function as column material for a generator.
참고문헌 (8)
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