18F-FDG 영상에서 암 추적 인자에 영향을 미치는 매개 변수 연구: 췌장암 중심으로
Study of Parameters Affecting Cancer Tracking Factors in 18F-FDG Images: Centered on Pancreatic Cancer
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
This study is a statistical analysis of a patient’s parameters affecting cancer trackingfactors for pancreatic cancer identification in a double-point PET/CT scan. The correlationcoefficient between the C-value that distinguishes pancreatic cancer and the patient's genderwas not significant (p<0.05). Through statistical analysis, the patient’s age, gender, and 18F-FDGinfusion were not statistically significant in identifying pancreatic cancer (p<0.05). In the Pearsoncorrelation analysis, the correlation coefficient r=0.725 of C-value and delayed SUVm was highlyevaluated. The correlation index r=0.32 between the primary PET/CT 60 min scan SUVm andthe C-value performed 60 min after 18F-FDG injection is low.In other words, applying a delayedtest to track pancreatic cancer is statistically more useful than a single time PET/CT Scan(p<0.05). The delay Scan time that distinguishes benign disease from pancreatic cancer is 120minutes more useful than 180 minutes (p<0.05). This study is meaningful in that it presented astatistical approach to the usefulness of the parameters of cancer follow-up SUVm, C-velue, andthe parameters of patients and the delayed test time in dual time point PET/CT Scan.
Abstract
This study is a statistical analysis of a patient’s parameters affecting cancer trackingfactors for pancreatic cancer identification in a double-point PET/CT scan. The correlationcoefficient between the C-value that distinguishes pancreatic cancer and the patient's genderwas not significant (p<0.05). Through statistical analysis, the patient’s age, gender, and 18F-FDGinfusion were not statistically significant in identifying pancreatic cancer (p<0.05). In the Pearsoncorrelation analysis, the correlation coefficient r=0.725 of C-value and delayed SUVm was highlyevaluated. The correlation index r=0.32 between the primary PET/CT 60 min scan SUVm andthe C-value performed 60 min after 18F-FDG injection is low.In other words, applying a delayedtest to track pancreatic cancer is statistically more useful than a single time PET/CT Scan(p<0.05). The delay Scan time that distinguishes benign disease from pancreatic cancer is 120minutes more useful than 180 minutes (p<0.05). This study is meaningful in that it presented astatistical approach to the usefulness of the parameters of cancer follow-up SUVm, C-velue, andthe parameters of patients and the delayed test time in dual time point PET/CT Scan.
참고문헌 (7)
- 장보석, "PET", CT 검사에서 췌장암 판별을 위한 SUVm 경계값 연구, 2017, pp.17(10), 567~575[DOI]
- Kubota K, "From tumor biology to clinical Pet : a review of positron emission tomography(PET)in oncology", Ann. Nucl, 15(6), pp.471~486 (2001)
- -2-deoxy-D-glucose(FDG)uptake in human tumorcells is related to the expression of GLUT-1 and hexokinase II, "Acta Radiol", 2008, 1145~1153
- Parghane RV, "Dual-time point 18F-FDG-PET and PET", CT for Differentiating Benign From Malignant Musculoskeletal Lesions : Opportunities and Limitations, 2017, pp.47(4), 373~391
- Southworth R, "Tissue-specific differences in 2-fluoro-2-deoxy glucose metabolism beyond FDG-6-P : a 19F NMR spectroscopy studyin the rat", NMR Biomed, 16(8), pp.494~502 (2003)
- -fluoro-2-deoxy-D-glucose : variations with body weight and a method for correction, "Radiology", 1993, 847~850
- Zhuang H, "Lambri dual time point 18F-FDG PET imaging for differentiating malignant from inflammatory processes", J. Nucl. Med, 42(9), pp.1412~1417 (2001)