RI-Biomics분야 RI의 최신 동향 분석

Abstract

RI-Biomics is a new compound word of radiation technology and Biomics related tothe study of life. RI-Biomics is high radiation fusion technology by combining evaluation ofpharmacokinetics in vivo (RI-ADME) of new drugs and medical materials using radioisotope andmolecular imaging technology using nuclear medicine equipments. RI-Biomics fields are emergingwith the increasing usage of radioisotopes (RI). In this paper, we investigated the latest trendsof radioisotope using in RI-Biomics fields. The representative radioisotopes are 14C, 3H and 32Pfor the optimization and the selection of candidates in the development process of new drugsamong the RI-Biomics fields. As shown in the status of accumulated income of radioisotopes, usingamounts of radioisotopes are showing a tendency to increase every year. 14C is 61.6% increase ofaccumulated income growth rate and 3H increased by 58.8% and 32P increased by 33.9% in 2012compared to 2007. These isotopes are used in a variety of fields as using of 14C for microdosingtest, development of [3H]cholesterol absorption inhibitors, study of [131I]pyronaridine tetraphosphatefor malaria therapy. These are going on in vivo test sucessfully. So, clinical research step isexpected to begin soon. Therefore, usages of radioisotopes are necessary and need for the evaluationof pharmacokinetics, optimization and the selection of new drug candidates in the developmentprocess of new drugs among the RI-Biomics fields. So, using of radioisotopes is predict toincrease continuously except for primarily used 14C, 3H.