Coronary Calcification Is Reversely Related with Bone and Hair Calcium: The Relationship among Different Calcium Pools in Body
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Background: With aging, calcium efflux from bone is increased with age-related bone loss, and it can reduce bone mineral density (BMD). On the contrary, age-related calcium adoption into arterial wall progressively stiffens blood vessels. Theses process insinuates shift of calcium among different pools in body. However, their relationships have not been elucidated yet. So we investigated the correlation among calcium contents in different body pools, such as hair, bone, and blood vessels in women. Methods: We analyzed 50 females retrospectively who measured Agatston coronary artery calcium score (CACS), BMD, and hair calcium concentration at a regular health check-up in a university hospital. CACS was achieved by coronary multidetector computed tomography, BMD was measured by dual energy X-ray absorptiometry in the lumbar spine and femur, and hair calcium level was checked by hair tissue mineral analysis. Results: CACS inversely correlated with BMD (r=-0.280, P=0.049 with lumbar vertebrae 1-4, r=-0.310, P=0.028 with femur neck, r=-0.333, P=0.018 with femur total) and hair calcium concentration (r=-0.352, P=0.012). Conclusions: CACS has negative correlation with BMD and hair calcium level in women. Different body calcium pools such as bone, hair and blood vessel significantly correlated each other.
Abstract
Background: With aging, calcium efflux from bone is increased with age-related bone loss, and it can reduce bone mineral density (BMD). On the contrary, age-related calcium adoption into arterial wall progressively stiffens blood vessels. Theses process insinuates shift of calcium among different pools in body. However, their relationships have not been elucidated yet. So we investigated the correlation among calcium contents in different body pools, such as hair, bone, and blood vessels in women. Methods: We analyzed 50 females retrospectively who measured Agatston coronary artery calcium score (CACS), BMD, and hair calcium concentration at a regular health check-up in a university hospital. CACS was achieved by coronary multidetector computed tomography, BMD was measured by dual energy X-ray absorptiometry in the lumbar spine and femur, and hair calcium level was checked by hair tissue mineral analysis. Results: CACS inversely correlated with BMD (r=-0.280, P=0.049 with lumbar vertebrae 1-4, r=-0.310, P=0.028 with femur neck, r=-0.333, P=0.018 with femur total) and hair calcium concentration (r=-0.352, P=0.012). Conclusions: CACS has negative correlation with BMD and hair calcium level in women. Different body calcium pools such as bone, hair and blood vessel significantly correlated each other.
참고문헌 (37)
- Warming L, "Changes in bone mineral density with age in men and women : a longitudinal study", Osteoporos Int, 13, pp.105~112 (2002)
- Marshall D, "Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures", BMJ, 312, pp.1254~1259 (1996)
- Lakatta EG, "Arterial and cardiac aging : major shareholders in cardiovascular disease enterprises : Part I : aging arteries : a"set up"for vascular disease", Circulation, 107, pp.139~146 (2003)
- Prabhakaran S, "Presence of calcified carotid plaque predicts vascular events: the Northern Manhattan Study", Atherosclerosis, 195, pp.e197~e201 (2007)
- Hak AE, "Progression of aortic calcification is associated with metacarpal bone loss during menopause : a population-based longitudinal study", Arterioscler Thromb Vasc Biol, 20, pp.1926~1931 (2000)
- Kiel DP, "Bone loss and the progression of abdominal aortic calcification over a 25 year period : the Framingham Heart Study", Calcif Tissue Int, 68, pp.271~276 (2001)
- von der Recke P, "The association between low bone mass at the menopause and cardiovascular mortality", Am J Med, 106, pp.273~278 (1999)
- Agatston AS, "Quantification of coronary artery calcium using ultrafast computed tomography", J Am Coll Cardiol, 15, pp.827~832 (1990)
- van der Bijl N, "Assessment of Agatston coronary artery calcium score using contrast-enhanced CT coronary angiography", AJR Am J Roentgenol, 195, pp.1299~1305 (2010)
- Kopp AF, "Reproducibility and accuracy of coronary calcium measurements with multi-detector row versus electron-beam CT", Radiology, 225, pp.113~119 (2002)
- Oei HH, "The association between coronary calcification assessed by electron beam computed tomography and measures of extracoronary atherosclerosis : the Rotterdam Coronary Calcification Study", J Am Coll Cardiol, 39, pp.1745~1751 (2002)
- Pletcher MJ, "Using the coronary artery calcium score to predict coronary heart disease events : a systematic review and meta-analysis", Arch Intern Med, 164, pp.1285~1292 (2004)
- Detrano R, "Coronary calcium as a predictor of coronary events in four racial or ethnic groups", N Engl J Med, 358, pp.1336~1345 (2008)
- Harkins DK, "Hair analysis : exploring the state of the science", Environ Health Perspect, 111, pp.576~578 (2003)
- Klevay LM, "Hair analysis in clinical and experimental medicine", Am J Clin Nutr, 46, pp.233~236 (1987)
- Miekeley N, "Elemental anomalies in hair as indicators of endocrinologic pathologies and deficiencies in calcium and bone metabolism", J Trace Elem Med Biol, 15, pp.46~55 (2001)
- MacPherson A, "Relationship of hair calcium concentration to incidence of coronary heart disease", Sci Total Environ, 255, pp.11~19 (2000)
- Park SJ, "Hair calcium concentration is associated with calcium intake and bone mineral density", Int J Vitam Nutr Res, 83, pp.154~161 (2013)
- Sinnott B, "Coronary calcification and osteoporosis in men and postmenopausal women are independent processes associated with aging", Calcif Tissue Int, 78, pp.195~202 (2006)
- Kim KI, "Is reduced bone mineral density independently associated with coronary artery calcification in subjects older than 50 years?", J Bone Miner Metab, 29, pp.369~376 (2011)
- Hyder JA, "Association of coronary artery and aortic calcium with lumbar bone density : the MESA Abdominal Aortic Calcium Study", Am J Epidemiol, 169, pp.186~194 (2009)
- Choi SH, "Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre-and postmenopausal women", Clin Endocrinol, 71, pp.644~651 (2009)
- Jensky NE, "The association of bone density and calcified atherosclerosis is stronger in women without dyslipidemia : the multi-ethnic study of atherosclerosis", J Bone Miner Res, 26, pp.2702~2709 (2011)
- Grady D, "Hormone therapy to prevent disease and prolong life in postmenopausal women", Ann Intern Med, 117, pp.1016~1037 (1992)
- Bauer DC, "Factors associated with appendicular bone mass in older women. The Study of Osteoporotic Fractures Research Group", Ann Intern Med, 118, pp.657~665 (1993)
- Losordo DW, "Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women", Circulation, 89, pp.1501~1510 (1994)
- Eriksen EF, "Evidence of estrogen receptors in normal human osteoblast-like cells", Science, 241, pp.84~86 (1988)
- Oursler MJ, "Human giant cell tumors of the bone(osteoclastomas)are estrogen target cells", Proc Natl Acad Sci U S A, 91, pp.5227~5231 (1994)
- Doherty TM, "Molecular, endocrine, and genetic mechanisms of arterial calcification", Endocr Rev, 25, pp.629~672 (2004)
- Song CH, "Associations of calcium and magnesium in serum and hair with bone mineral density in premenopausal women", Biol Trace Elem Res, 118, pp.1~9 (2007)
- Nordin BE, "Bone formation and resorption as the determinants of trabecular bone volume in postmenopausal osteoporosis", Lancet, 2, pp.277~279 (1981)
- Potts JT, "Progress, paradox, and potential: parathyroid hormone research over five decades", Ann N Y Acad Sci, 1117, pp.196~208 (2007)
- Jurutka PW, "Molecular nature of the vitamin D receptor and its role in regulation of gene expression", Rev Endocr Metab Disord, 2, pp.203~216 (2001)
- Shin S, "Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography", Eur Heart J, 33, pp.2873~2881 (2012)
- Ian R Reid, "Should We Prescribe Calcium Supplements For Osteoporosis Prevention?", 대한골대사학회지, 21(1), pp.21~28 (2014), 대한골대사학회
- 김경민, "Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research", 대한골대사학회지, 22(4), pp.143~149 (2015), 대한골대사학회
- Yang YJ, "Factors in relation to bone mineral density in Korean middle-aged and older men : 2008-2010 Korea National Health and Nutrition Examination Survey", Ann Nutr Metab, 64, pp.50~59 (2014)
