Correlation of Arterial Stiffness and Bone Mineral Density by Measuring Brachial-Ankle Pulse Wave Velocity in Healthy Korean Women
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: An association between arterial stiffness and osteoporosis has previously been reported. Therefore, we investigated the relationship between arterial stiffness, measured by brachial-ankle pulse wave velocity, and bone mineral density in a sample of healthy women undergoing routine medical checkup. Methods: We retrospectively reviewed the medical charts of 135 women who had visited the Health Promotion Center (between May 2009 and December 2012). Brachial-ankle pulse wave velocity was measured using an automatic wave analyzer. Bone mineral density of the lumbar spine (L1–L4) and femur was measured by dual-energy Xray absorptiometry. Metabolic syndrome was defined according to National Cholesterol Education Program–Adult Treatment Panel III criteria, using body mass index >25 kg/m2 instead of waist circumference >88.9 cm. Results: Pearson’s correlation analysis revealed significant inverse relationships between pulse wave velocity and bone mineral density of the lumbar spine (r=-0.335, P<0.001), femur neck (r=-0.335, P<0.001), and total femur (r=-0.181, P=0.04). Pulse wave velocity showed the strongest association with age (r=0.586, P<0.001). Multiple regression analysis identified an independent relationship between pulse wave velocity and lumbar spine bone mineral density in women after adjusting for age, metabolic syndrome, body mass index, smoking status, alcohol intake, and exercise (r=-0.229, P=0.01). Conclusion: This study confirmed an association between arterial stiffness and bone mineral density in women.
Abstract
Background: An association between arterial stiffness and osteoporosis has previously been reported. Therefore, we investigated the relationship between arterial stiffness, measured by brachial-ankle pulse wave velocity, and bone mineral density in a sample of healthy women undergoing routine medical checkup. Methods: We retrospectively reviewed the medical charts of 135 women who had visited the Health Promotion Center (between May 2009 and December 2012). Brachial-ankle pulse wave velocity was measured using an automatic wave analyzer. Bone mineral density of the lumbar spine (L1–L4) and femur was measured by dual-energy Xray absorptiometry. Metabolic syndrome was defined according to National Cholesterol Education Program–Adult Treatment Panel III criteria, using body mass index >25 kg/m2 instead of waist circumference >88.9 cm. Results: Pearson’s correlation analysis revealed significant inverse relationships between pulse wave velocity and bone mineral density of the lumbar spine (r=-0.335, P<0.001), femur neck (r=-0.335, P<0.001), and total femur (r=-0.181, P=0.04). Pulse wave velocity showed the strongest association with age (r=0.586, P<0.001). Multiple regression analysis identified an independent relationship between pulse wave velocity and lumbar spine bone mineral density in women after adjusting for age, metabolic syndrome, body mass index, smoking status, alcohol intake, and exercise (r=-0.229, P=0.01). Conclusion: This study confirmed an association between arterial stiffness and bone mineral density in women.
참고문헌 (25)
- Von der Recke P, "The association between low bone mass at the menopause and cardiovascular mortality", Am J Med, 106, pp.273~278 (1999)
- Kado DM, "Rate of bone loss is associated with mortality in older women: a prospective study", J Bone Miner Res, 15, pp.1974~1980 (2000)
- Marcovitz PA, "Usefulness of bone mineral density to predict significant coronary artery disease", Am J Cardiol, 96, pp.1059~1063 (2005)
- Magnus JH, "Relationship between bone mineral density and myocardial infarction in US adults", Osteoporos Int, 16, pp.2053~2062 (2005)
- Hak AE, "Progression of aortic calcification is associated with metacarpal bone loss during menopause: a population-based longitudinal study", Arterioscler Thromb Vasc Biol, 20, pp.1926~1931 (2000)
- Schulz E, "Aortic calcification and the risk of osteoporosis and fractures", J Clin Endocrinol Metab, 89, pp.4246~4253 (2004)
- Tanko LB, "Low bone mineral density in the hip as a marker of advanced atherosclerosis in elderly women", Calcif Tissue Int, 73, pp.15~20 (2003)
- Hirose K, "Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia", J Clin Endocrinol Metab, 88, pp.2573~2578 (2003)
- Mikumo M, "Association between lumbar bone mineral density and vascular stiffness as assessed by pulse wave velocity in postmenopausal women", J Bone Miner Metab, 27, pp.89~94 (2009)
- McFarlane SI, "Bone mineral density as a predictor of atherosclerosis and arterial wall stiffness in obese African-American women", Cardiorenal Med, 2, pp.328~334 (2012)
- Yamashina A, "Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement", Hypertens Res, 25, pp.359~364 (2002)
- Sugawara J, "Brachial-ankle pulse wave velocity: an index of central arterial stiffness?", J Hum Hypertens, 19, pp.401~406 (2005)
- Tomiyama H, "Brachial-ankle pulse wave velocity is a simple and independent predictor of prognosis in patients with acute coronary syndrome", Circ J, 69, pp.815~822 (2005)
- Kitahara T, "Impact of brachial-ankle pulse wave velocity and ankle-brachial blood pressure index on mortality in hemodialysis patients", Am J Kidney Dis, 46, pp.688~696 (2005)
- Meguro T, "Elevated arterial stiffness evaluated by brachial-ankle pulse wave velocity is deleterious for the prognosis of patients with heart failure", Circ J, 73, pp.673~680 (2009)
- 이형택, "The Relationship Between Coronary Artery Calcification and Bone Mineral Density in Patients According to Their Metabolic Syndrome Status", Korean Circulation Journal, 41(2), pp.76~82 (2011), 대한심장학회
- Gourdy P, "Role of inflammatory cytokines in the effect of estradiol on atheroma", Clin Exp Pharmacol Physiol, 35, pp.396~401 (2008)
- Maziere C, "Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling", J Cell Physiol, 221, pp.572~578 (2009)
- Demer LL., "Vascular calcification and osteoporosis: inflammatory responses to oxidized lipids", Int J Epidemiol, 31, pp.737~741 (2002)
- Browner WS, "Associations of serum osteoprotegerin levels with diabetes, stroke, bone density, fractures, and mortality in elderly women", J Clin Endocrinol Metab, 86, pp.631~637 (2001)
- Frost ML, "Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening", Calcif Tissue Int, 83, pp.112~120 (2008)
- Yoshimura N, "Bone loss at the lumbar spine and the proximal femur in a rural Japanese community, 1990-2000: the Miyama study", Osteoporos Int, 13, pp.803~808 (2002)
- Weng C, "Age- and gender dependent association between components of metabolic syndrome and subclinical arterial stiffness in a Chinese population", Int J Med Sci, 9, pp.730~737 (2012)
- Young-Kwon Kim, "Impact of the Metabolic Syndrome and Its Components on Pulse Wave Velocity", The Korean Journal of Internal Medicine, 21(2), pp.109~115 (2006), 대한내과학회
- Giallauria F, "Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging", J Clin Endocrinol Metab, 97, pp.3717~3723 (2012)