Incretin-Based Therapies: A Promising Approach for Modulating Oxidative Stress and Insulin Resistance in Sarcopenia
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: Recent studies have linked sarcopenia development to the hallmarks of diabetes, oxidative stress, and insulin resistance. The anti-oxidant and insulin sensitivityenhancing effects of incretin-based therapies may provide a promising option for the treatment of sarcopenia. This review aimed to unveil the role of oxidative stress and insulin resistance in the pathogenesis of sarcopenia and explore the potential benefits of incretin-based therapies in individuals with sarcopenia. Methods: PubMed, the Cochrane Library, and Google Scholar databases were searched by applying keywords relevant to the main topic, to identify articles that met our selection criteria. Results: Incretin- based therapies manifested anti-oxidant effects by increasing the anti-oxidant defense system and decreasing free radical generation or by indirectly minimizing glucotoxicity, which was mainly achieved by improving insulin signaling and glucose homeostasis. Likewise, these drugs exhibit insulin-sensitizing activities by increasing insulin secretion, transduction, and β-cell function or by reducing inflammation and lipotoxicity. Conclusions: Incretin-based therapies, as modulators of oxidation and insulin resistance, may target the main pathophysiological factors of sarcopenia, thus providing a promising strategy for the treatment of this disease.
Abstract
Background: Recent studies have linked sarcopenia development to the hallmarks of diabetes, oxidative stress, and insulin resistance. The anti-oxidant and insulin sensitivityenhancing effects of incretin-based therapies may provide a promising option for the treatment of sarcopenia. This review aimed to unveil the role of oxidative stress and insulin resistance in the pathogenesis of sarcopenia and explore the potential benefits of incretin-based therapies in individuals with sarcopenia. Methods: PubMed, the Cochrane Library, and Google Scholar databases were searched by applying keywords relevant to the main topic, to identify articles that met our selection criteria. Results: Incretin- based therapies manifested anti-oxidant effects by increasing the anti-oxidant defense system and decreasing free radical generation or by indirectly minimizing glucotoxicity, which was mainly achieved by improving insulin signaling and glucose homeostasis. Likewise, these drugs exhibit insulin-sensitizing activities by increasing insulin secretion, transduction, and β-cell function or by reducing inflammation and lipotoxicity. Conclusions: Incretin-based therapies, as modulators of oxidation and insulin resistance, may target the main pathophysiological factors of sarcopenia, thus providing a promising strategy for the treatment of this disease.
참고문헌 (100)
- Ji S, "Sarcopenia as the mobility phenotype of aging : clinical implications", J Bone Metab, 31, pp.1~12 (2024)[DOI]
- Cruz-Jentoft AJ, "Sarcopenia : revised European consensus on definition and diagnosis", Age Ageing, 48, pp.16~31 (2019)[DOI]
- Petermann-Rocha F, "Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality : a prospective study from UK Biobank", Maturitas, 138, pp.69~75 (2020)[DOI]
- Lim HS, "Association of dietary variety status and sarcopenia in Korean elderly", J Bone Metab, 27, pp.143~149 (2020)[DOI]
- Petermann-Rocha F, "Factors associated with sarcopenia : a cross-sectional analysis using UK Biobank", Maturitas, 133, pp.60~67 (2020)[DOI]
- Ahmed GM, "Impact of calcium channel blockers and angiotensin receptor blockers on hematological parameters in type 2 diabetic patients", Naunyn Schmiedebergs Arch Pharmacol, 397, pp.1817~1828 (2024)[DOI]
- Hadid KA, "Mechanisms and linkage of insulin signaling, resistance, and inflammation", Iraq J Pharm, 21, pp.1~8 (2024)[DOI]
- Hadid KA, "Beyond blood sugar : exploring the anti-inflammatory frontier of antidiabetic medications to alleviate diabetic complications", Rom J Med Pract, 19, pp.92~99 (2024)[DOI]
- Faselis C, "Microvascular complications of type 2 diabetes mellitus", Curr Vasc Pharmacol, 18, pp.117~124 (2020)[DOI]
- Ahmed GM, "The diabetic-anemia nexus : Implications for clinical practice", Mil Med Sci Lett, 92, pp.1~11 (2023)[DOI]
- Trujillo JM, "GLP-1 receptor agonists : a review of head-to-head clinical studies", Ther Adv Endocrinol Metab, 6, pp.19~28 (2015)[DOI]
- Nauck MA, "The evolving story of incretins(GIP and GLP-1)in metabolic and cardiovascular disease : a pathophysiological update", Diabetes Obes Metab, 23(Suppl 3), pp.5~29 (2021)[DOI]
- Chai S, "Cognitive protection of incretinbased therapies in patients with type 2 diabetes mellitus : a systematic review and meta-analysis based on clinical studies", J Diabetes Investig, 14, pp.864~873 (2023)[DOI]
- Guo C, "Glucagon-like peptide 1improves insulin resistance in vitro through anti-inflammation of macrophages", Braz J Med Biol Res, 49, pp.e5826~ (2016)[DOI]
- Sandoval D, "Brain GLP-1 and insulin sensitivity", Mol Cell Endocrinol, 418(Pt 1), pp.27~32 (2015)[DOI]
- Yaribeygi H, "Antioxidative potentials of incretin-based medications : a review of molecular mechanisms", Oxid Med Cell Longev, 2021, pp.9959320~ (2021)[DOI]
- Alfahad M, "Comparison of anti-oxidant activity of different brands of esomeprazole available in Iraqi pharmacies", Syst Rev Pharm, 11, pp.330~334 (2020)[DOI]
- Bellanti F, "Aging:oxidative stress and dietary antioxidants" (2020), Elsevier Inc
- Baek KW, "Rodent model of muscular atrophy for sarcopenia study", J Bone Metab, 27, pp.97~110 (2020)[DOI]
- Léger B, "Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy", J Physiol, 576, pp.923~933 (2006)[DOI]
- Handayaningsih AE, "Reactive oxygen species play an essential role in IGF-I signaling and IGF-I-induced myocyte hypertrophy in C2C12 myocytes", Endocrinology, 152, pp.912~921 (2011)[DOI]
- Thomson DM, "Impaired overload-induced muscle growth is associated with diminished translational signalling in aged rat fast-twitch skeletal muscle", J Physiol, 574, pp.291~305 (2006)[DOI]
- Yoshida T, "Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy", Cells, 9, pp.1970~ (2020)[DOI]
- Sakellariou GK, "Studies of mitochondrial and nonmitochondrial sources implicate nicotinamide adenine dinucleotide phosphate oxidase(s)in the increased skeletal muscle superoxide generation that occurs during contractile activity", Antioxid Redox Signal, 18, pp.603~621 (2013)[DOI]
- Kim MJ, "The link between mitochondrial dysfunction and sarcopenia : an update focusing on the role of pyruvate dehydrogenase kinase 4", Diabetes Metab J, 47, pp.153~163 (2023)[DOI]
- Yeo D, "Intensified mitophagy in skeletal muscle with aging is downregulated by PGC-1alpha overexpression in vivo", Free Radic Biol Med, 130, pp.361~368 (2019)[DOI]
- Chabi B, "Mitochondrial function and apoptotic susceptibility in aging skeletal muscle", Aging Cell, 7, pp.2~12 (2008)[DOI]
- Marzetti E, "Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle", Mech Ageing Dev, 129, pp.542~549 (2008)[DOI]
- St-Pierre J, "Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators", Cell, 127, pp.397~408 (2006)[DOI]
- Alassaf FA, "Effects of bee propolis on fbg, hba1c, and insulin resistance in healthy volunteers", Turk J Pharm Sci, 18, pp.405~409 (2021)[DOI]
- Liu ZJ, "Causal relationship between insulin resistance and sarcopenia", Diabetol Metab Syndr, 15, pp.46~ (2023)[DOI]
- White JP, "Amino acid trafficking and skeletal muscle protein synthesis : a case of supply and demand", Front Cell Dev Biol, 9, pp.656604~ (2021)[DOI]
- Ibrahim SL, "Inhibition of branched-chain alpha-keto acid dehydrogenase kinase augments the sensitivity of ovarian and breast cancer cells to paclitaxel", Br J Cancer, 128, pp.896~906 (2023)[DOI]
- Long YC, "Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways", Mol Cell Biol, 31, pp.430~441 (2011)[DOI]
- Vanhaesebroeck B, "PI3K signalling : the path to discovery and understanding", Nat Rev Mol Cell Biol, 13, pp.195~203 (2012)[DOI]
- Lee MK, "Protective effect of pyropia yezoensis peptide on dexamethasone-induced myotube atrophy in C2C12 myotubes", Mar Drugs, 17, pp.284~ (2019)[DOI]
- Timmerman KL, "Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults", Diabetes, 59, pp.2764~2771 (2010)[DOI]
- Cleasby ME, "Insulin resistance and sarcopenia : mechanistic links between common comorbidities", J Endocrinol, 229, pp.R67~R81 (2016)[DOI]
- Ebert SM, "Stress-induced skeletal muscle Gadd45a expression reprograms myonuclei and causes muscle atrophy", J Biol Chem, 287, pp.27290~27301 (2012)[DOI]
- Santos BF, "FOXO family isoforms", Cell Death Dis, 14, pp.702~ (2023)[DOI]
- Mankhong S, "Experimental models of sarcopenia : bridging molecular mechanism and therapeutic strategy", Cells, 9, pp.1385~ (2020)[DOI]
- Adeva-Andany MM, "The effects of glucagon and the target of rapamycin(TOR)on skeletal muscle protein synthesis and age-dependent sarcopenia in humans", Clin Nutr ESPEN, 44, pp.15~25 (2021)[DOI]
- Ramasubbu K, "Impairment of insulin signaling pathway PI3K", Akt, Mol Cell Biochem, pp.2023, 478[DOI]
- Hurrle S, "The etiology of oxidative stress in insulin resistance", Biomed J, 40, pp.257~262 (2017)[DOI]
- Abed MN, "Comparison of antioxidant effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole", Pharmacology, 105, pp.645~651 (2020)[DOI]
- Yaribeygi H, "Insulin resistance : review of the underlying molecular mechanisms", J Cell Physiol, 234, pp.8152~8161 (2019)[DOI]
- Yaribeygi H, "A review of the molecular mechanisms of hyperglycemia-induced free radical generation leading to oxidative stress", J Cell Physiol, 234, pp.1300~1312 (2019)[DOI]
- Yaribeygi H, "Antioxidative potential of antidiabetic agents : a possible protective mechanism against vascular complications in diabetic patients", J Cell Physiol, 234, pp.2436~2446 (2019)[DOI]
- Khamseh ME, "Sarcopenia and diabetes : pathogenesis and consequences", Br J Diabetes Vasc Dis, 11, pp.230~234 (2011)[DOI]
- Mesinovic J, "Sarcopenia and type 2 diabetes mellitus : a bidirectional relationship", Diabetes Metab Syndr Obes, 12, pp.1057~1072 (2019)[DOI]
- Purnamasari D, "Sarcopenia and chronic complications of type 2 diabetes mellitus", Rev Diabet Stud, 18, pp.157~165 (2022)[DOI]
- Tack W, "Pathophysiological interactions between sarcopenia and type 2 diabetes : a two-way street influencing diagnosis and therapeutic options", Diabetes Obes Metab, 26, pp.407~416 (2024)[DOI]
- Bernardini F, "Incretins-based therapies and their cardiovascular effects : new game-changers for the management of patients with diabetes and cardiovascular disease", Pharmaceutics, 15, pp.1858~ (2023)[DOI]
- Kobayashi M, "The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds", Mol Cell Biol, 29, pp.493~502 (2009)[DOI]
- Civantos E, "Sitagliptin ameliorates oxidative stress in experimental diabetic nephropathy by diminishing the miR-200a", Keap-1, Diabetes Metab Syndr Obes, pp.2017, 10[DOI]
- Li Q, "GLP-1 inhibits high-glucose-induced oxidative injury of vascular endothelial cells", Sci Rep, 7, pp.8008~ (2017)[DOI]
- Shiraki A, "Glucagon-like peptide 1 analog liraglutide reduces TNF-α-induced oxidative stress and inflammation", J Am Coll Cardiol, 59, pp.E904~ (2012)[DOI]
- Deng C, "Liraglutide activates the Nrf2", HO-1antioxidant pathway and protects brain nerve cells against cerebral ischemia in diabetic rats, 2018, pp.2018, 3094504~
- Alsalim W, "Effect of singledose DPP-4 inhibitor sitagliptin on β-cell function and incretin hormone secretion after meal ingestion in healthy volunteers and drug-naïve, well-controlled type 2 diabetes subjects", Diabetes Obes Metab, 20, pp.1080~1085 (2018)[DOI]
- Armstrong MJ, "Glucagon-like peptide 1 decreases lipotoxicity in non-alcoholic steatohepatitis", J Hepatol, 64, pp.399~408 (2016)[DOI]
- Jasim MHM, "Synthesis, characterization, ADME study and in-vitro anti-inflammatory activity of aspirin amino acid conjugates", Pharm Chem J, 57, pp.243~249 (2023)[DOI]
- Thomas MK, "Dual GIP and GLP-1 receptor agonist tirzepatide improves beta-cell function and insulin sensitivity in type 2 diabetes", J Clin Endocrinol Metab, 106, pp.388~396 (2021)[DOI]
- Meloni AR, "GLP-1 receptor activated insulin secretion from pancreatic β-cells : mechanism and glucose dependence", Diabetes Obes Metab, 15, pp.15~27 (2013)[DOI]
- Lee YS, "Anti-inflammatory effects of GLP-1-based therapies beyond glucose control", Mediators Inflamm, 2016, pp.3094642~ (2016)[DOI]
- Giannocco G, "Dipeptidyl peptidase IV inhibition upregulates GLUT4 translocation and expression in heart and skeletal muscle of spontaneously hypertensive rats", Eur J Pharmacol, 698, pp.74~86 (2013)[DOI]
- Silva Júnior WS, "Dipeptidyl peptidase 4 activity is related to body composition, measures of adiposity, and insulin resistance in subjects with excessive adiposity and different degrees of glucose tolerance", J Diabetes Res, 2019, pp.5238013~ (2019)[DOI]
- Kim MH, "EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage", Toxicol Appl Pharmacol, 315, pp.60~69 (2017)[DOI]
- Kawamori D, "GLP-1 signalling compensates for impaired insulin signalling in regulating beta cell proliferation in βIRKO mice", Diabetologia, 60, pp.1442~1453 (2017)[DOI]
- Shimoda M, "The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes", Diabetologia, 54, pp.1098~1108 (2011)[DOI]
- Tomas E, "GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes", Regul Pept, 167, pp.177~184 (2011)[DOI]
- Puddu A, "An emerging role of glucagon-like peptide-1 in preventing advanced-glycation-end-product-mediated damages in diabetes", Mediators Inflamm, 2013, pp.591056~ (2013)[DOI]
- Patel V, "Combination of omeprazole with GLP-1 agonist therapy improves insulin sensitivity and antioxidant activity in liver in type 1diabetic mice", Pharmacol Rep, 65, pp.927~936 (2013)[DOI]
- Okada K, "Effects of treatment with liraglutide on oxidative stress and cardiac natriuretic peptide levels in patients with type 2 diabetes mellitus", Endocrine, 47, pp.962~964 (2014)[DOI]
- Rizzo M, "Liraglutide reduces oxidative stress and restores heme oxygenase-1 and ghrelin levels in patients with type 2 diabetes : a prospective pilot study", J Clin Endocrinol Metab, 100, pp.603~606 (2015)[DOI]
- Fernández-Millán E, "Glucagonlike peptide-1 improves beta-cell antioxidant capacity via extracellular regulated kinases pathway and Nrf2 translocation", Free Radic Biol Med, 95, pp.16~26 (2016)[DOI]
- Oh YS, "Effects of glucagon-like peptide-1 on oxidative stress and Nrf2 signaling", Int J Mol Sci, 19, pp.26~ (2017)[DOI]
- Cardoso JFR, "Perspectives of incretin mimetics in cardiovascular diseases", Braz J Health Biomed Sci, 20, pp.55~62 (2021)[DOI]
- Girges C, "The future of incretin-based approaches for neurodegenerative diseases in older adults: which to choose? A review of their potential efficacy and suitability", Drugs Aging, 38, pp.355~373 (2021)[DOI]
- Kalaitzoglou E, "Diabetes pharmacotherapy and effects on the musculoskeletal system", Diabetes Metab Res Rev, 35, pp.e3100~ (2019)[DOI]
- Gilbert MP, "GLP-1 analogs and DPP-4 inhibitors in type 2 diabetes therapy : review of head-to-head clinical trials", Front Endocrinol(Lausanne), 11, pp.178~ (2020)[DOI]
- Yaribeygi H, "Molecular mechanisms by which GLP-1 RA and DPP-4i induce insulin sensitivity", Life Sci, 234, pp.116776~ (2019)[DOI]
- Duan K, "The clinical relevance and mechanism of skeletal muscle wasting", Clin Nutr, 40, pp.27~37 (2021)[DOI]
- Cetrone M, "Effects of the antidiabetic drugs on the age-related atrophy and sarcopenia associated with diabetes type II", Curr Diabetes Rev, 10, pp.231~237 (2014)[DOI]
- Alnaser RI, "Adulteration of hypoglycemic products : the silent threat", Rom J Med Pract, 18, pp.202~205 (2023)[DOI]
- Al-Dabbagh BMA, "Antiinflammatory, antioxidant and hepatoprotective potential of milk thistle in albino rats", Lat Am J Pharm, 41, pp.1832~1841 (2022)
- Andreozzi F, "The GLP-1 receptor agonists exenatide and liraglutide activate Glucose transport by an AMPK-dependent mechanism", J Transl Med, 14, pp.229~ (2016)[DOI]
- Colin IM, "Extrapancreatic effects of incretin hormones : evidence for weight-independent changes in morphological aspects and oxidative status in insulin-sensitive organs of the obese nondiabetic Zucker rat(ZFR)", Physiol Rep, 4, pp.e12886~ (2016)[DOI]
- Takada S, "Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling", Cardiovasc Res, 111, pp.338~347 (2016)[DOI]
- Perna S, "Liraglutide and obesity in elderly : efficacy in fat loss and safety in order to prevent sarcopenia. A perspective case series study", Aging Clin Exp Res, 28, pp.1251~1257 (2016)[DOI]
- Liu J, "Exenatide treatment increases serum irisin levels in patients with obesity and newly diagnosed type 2 diabetes", J Diabetes Complications, 30, pp.1555~1559 (2016)[DOI]
- Yajima T, "The effect of dulaglutide on body composition in type 2 diabetes mellitus patients on hemodialysis", J Diabetes Complications, 32, pp.759~763 (2018)[DOI]
- Friedrichsen M, "The effect of semaglutide 2.4 mg once weekly on energy intake, appetite, control of eating, and gastric emptying in adults with obesity", Diabetes Obes Metab, 23, pp.754~762 (2021)[DOI]
- Ard J, "Weight loss and maintenance related to the mechanism of action of glucagon-like peptide 1 receptor agonists", Adv Ther, 38, pp.2821~2839 (2021)[DOI]
- Moore PW, "GLP-1 agonists for weight loss : pharmacology and clinical implications", Adv Ther, 40, pp.723~742 (2023)[DOI]
- McLeod M, "Live strong and prosper : the importance of skeletal muscle strength for healthy ageing", Biogerontology, 17, pp.497~510 (2016)[DOI]
- Cohen S, "Muscle wasting in disease : molecular mechanisms and promising therapies", Nat Rev Drug Discov, 14, pp.58~74 (2015)[DOI]
- Locatelli JC, "Incretin-based weight loss pharmacotherapy: can resistance exercise optimize changes in body composition?", Diabetes Care, pp.dci230100~ (2024)[DOI]
- Hartono FA, "The effects of dietary protein supplementation on acute changes in muscle protein synthesis and longer-term changes in muscle mass, strength, and aerobic capacity in response to concurrent resistance and endurance exercise in healthy adults : a systematic review", Sports Med, 52, pp.1295~1328 (2022)[DOI]
- Hoffman MD, "Proper hydration during ultra-endurance activities", Sports Med Arthrosc Rev, 27, pp.8~14 (2019)[DOI]
- Bellicha A, "Effect of exercise training on weight loss, body composition changes, and weight maintenance in adults with overweight or obesity : an overview of 12 systematic reviews and 149 studies", Obes Rev, 22(Suppl 4), pp.e13256~ (2021)[DOI]
