Age- and Sex-Related Volumetric Density Differences in Trabecular and Cortical Bone of the Proximal Femur in Healthy Population
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Background: There are age- and sex-related increases in the prevalence of osteoporosis. Bone densitometry based on dual energy X-ray absorptiometry (DXA) is the gold standard for the assessment of bone mineral density (BMD). Three-dimensional (3D) analysis of the proximal femur (3D-DXA) allows discrimination between cortical and trabecular compartments, and it has shown a good correlation with computed tomography. We aimed to assess age- and sex-related volumetric density differences in trabecular and cortical bone using 3D-DXA and determine the reference intervals for integral volumetric (v)BMD within the Argentine population. Methods: Healthy female and male adult subjects (N=1,354) from Argentina were included. Hip BMD was measured using DXA, and 3D analysis was performed using 3D-Shaper software. The integral vBMD, cortical surface BMD, and trabecular vBMD (trab vBMD) were measured. Results: The study population included 73.9% women (N=1,001) and 26.13% men (N=353). We found a significant decrease in integral vBMD between 20 and 90 years in both sexes (women, -23.1%; men, -16.6%). Bone loss indicated in the integral vBMD results was mainly due to a decrease in trabecular bone in both sexes (women, -33.4%; men, -27.7%). The agerelated loss of cortical bone density was less and was limited to the female population, without no age-related differences in men. Moreover, 3D-DXA allowed us to propose reference intervals for integral vBMD. Conclusions: We found age- and sex-related bone loss between 20 and 90 years in an Argentine cohort via integral vBMD measurements using 3D-DXA, mainly due to decreases in trabecular bone in both sexes. The age-related loss of cortical bone density was less and was limited to the female population.
Abstract
Background: There are age- and sex-related increases in the prevalence of osteoporosis. Bone densitometry based on dual energy X-ray absorptiometry (DXA) is the gold standard for the assessment of bone mineral density (BMD). Three-dimensional (3D) analysis of the proximal femur (3D-DXA) allows discrimination between cortical and trabecular compartments, and it has shown a good correlation with computed tomography. We aimed to assess age- and sex-related volumetric density differences in trabecular and cortical bone using 3D-DXA and determine the reference intervals for integral volumetric (v)BMD within the Argentine population. Methods: Healthy female and male adult subjects (N=1,354) from Argentina were included. Hip BMD was measured using DXA, and 3D analysis was performed using 3D-Shaper software. The integral vBMD, cortical surface BMD, and trabecular vBMD (trab vBMD) were measured. Results: The study population included 73.9% women (N=1,001) and 26.13% men (N=353). We found a significant decrease in integral vBMD between 20 and 90 years in both sexes (women, -23.1%; men, -16.6%). Bone loss indicated in the integral vBMD results was mainly due to a decrease in trabecular bone in both sexes (women, -33.4%; men, -27.7%). The agerelated loss of cortical bone density was less and was limited to the female population, without no age-related differences in men. Moreover, 3D-DXA allowed us to propose reference intervals for integral vBMD. Conclusions: We found age- and sex-related bone loss between 20 and 90 years in an Argentine cohort via integral vBMD measurements using 3D-DXA, mainly due to decreases in trabecular bone in both sexes. The age-related loss of cortical bone density was less and was limited to the female population.
참고문헌 (51)
- Hui SL, "Bone mass in normal children and young adults", Growth, 49, pp.34~43 (1985)
- Kralick AE, "Evolutionary perspectives on the developing skeleton and implications for lifelong health", Front Endocrinol(Lausanne), 11, pp.99~ (2020)[DOI]
- Cooper C, "Review : Developmental origins of osteoporotic fracture", Osteoporos Int, 17, pp.337~347 (2006)[DOI]
- Hadji P, "Bone health in estrogen-free contraception", Osteoporos Int, 30, pp.2391~2400 (2019)[DOI]
- Lunt M, "Population-based geographic variations in DXA bone density in Europe : The EVOS Study. European Vertebral Osteoporosis", Osteoporos Int, 7, pp.175~189 (1997)[DOI]
- Looker AC, "Lumbar spine and proximal femur bone mineral density, bone mineral content, and bone area : United States, 2005-2008", Vital Health Stat, 11, pp.1~132 (2012)
- NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis and Therapy, "Osteoporosis prevention, diagnosis, and therapy", JAMA, 285, pp.785~795 (2001)[DOI]
- Kanis JA, "Assessment of fracture risk and its application to screening for postmenopausal osteoporosis : Synopsis of a WHO report. WHO Study Group", Osteoporos Int, 4, pp.368~381 (1994)[DOI]
- Siris ES, "Bone mineral density thresholds for pharmacological intervention to prevent fractures", Arch Intern Med, 164, pp.1108~1112 (2004)[DOI]
- Schuit SC, "Fracture incidence and association with bone mineral density in elderly men and women : The Rotterdam Study", Bone, 34, pp.195~202 (2004)[DOI]
- Bouxsein ML, "Considerations for development of surrogate endpoints for antifracture efficacy of new treatments in osteoporosis : A perspective", J Bone Miner Res, 23, pp.1155~1167 (2008)[DOI]
- Engelke K, "Clinical use of quantitative computed tomography(QCT)of the hip in the management of osteoporosis in adults : The 2015 ISCD official positions-Part I", J Clin Densitom, 18, pp.338~358 (2015)[DOI]
- Sfeir JG, "Evaluation of crosssectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using singleversus dual-energy quantitative computed tomography", Bone, 112, pp.145~152 (2018)[DOI]
- Cheng XG, "Assessment of the strength of proximal femur in vitro : Relationship to femoral bone mineral density and femoral geometry", Bone, 20, pp.213~218 (1997)[DOI]
- Clotet J, "Structural parameters of the proximal femur by 3-dimensional dual-energy X-ray absorptiometry software : Comparison with quantitative computed tomography", J Clin Densitom, 21, pp.550~562 (2018)[DOI]
- Humbert L, "3D analysis of cortical and trabecular bone from hip DXA : Precision and trend assessment interval in postmenopausal women", J Clin Densitom, 22, pp.214~218 (2019)[DOI]
- Humbert L, "3D-DXA : Assessing the femoral shape, the trabecular macrostructure and the cortex in 3D from DXA images", IEEE Trans Med Imaging, 36, pp.27~39 (2017)[DOI]
- Shuhart CR, "Executive summary of the 2019 ISCD position development conference on monitoring treatment, DXA cross-calibration and least significant change, spinal cord injury, peri-prosthetic and orthopedic bone health, transgender medicine, and pediatrics", J Clin Densitom, 22, pp.453~471 (2019)[DOI]
- Wu F, "Cut-points for associations between vitamin D status and multiple musculoskeletal outcomes in middle-aged women", Osteoporos Int, 28, pp.505~515 (2017)[DOI]
- Serdar MA, "Analysis of changes in parathyroid hormone and 25(OH)vitamin D levels with respect to age, gender and season : A data mining study", J Med Biochem, 36, pp.73~83 (2017)[DOI]
- Fong Y, "chngpt : Threshold regression model estimation and inference", BMC Bioinformatics, 18, pp.454~ (2017)[DOI]
- Harris EK, "On dividing reference data into subgroups to produce separate reference ranges", Clin Chem, 36, pp.265~270 (1990)
- Winzenrieth R, "Effects of osteoporosis drug treatments on cortical and trabecular bone in the femur using DXA-based 3D modeling", Osteoporos Int, 29, pp.2323~2333 (2018)[DOI]
- Brance ML, "Trabecular and cortical bone involvement in rheumatoid arthritis by DXA and DXA-based 3D modelling", Osteoporos Int, 32, pp.705~714 (2021)[DOI]
- Winzenrieth R, "Abaloparatide effects on cortical volumetric BMD and estimated strength indices of hip subregions by 3D-DXA in women with postmenopausal osteoporosis", J Clin Densitom, 25, pp.392~400 (2022)[DOI]
- Amani A, "Femur 3D-DXA assessment in female football players, swimmers, and sedentary controls", Int J Sports Med, 44, pp.420~426 (2023)[DOI]
- Takada J, "Effects of differences in dose and frequency of teriparatide on bone structure in Proximal Femur. -Analysis by DXA-based 3Dmodeling(3D-SHAPER Software)-TRIPLE-BONE study(The effects of TeRIParatide preparation on bone mineraL density increase and BONE structure)", Arch Osteoporos, 19, pp.55~ (2024)[DOI]
- Lewiecki EM, "3D-modeling from hip DXA shows improved bone structure with romosozumab followed by denosumab or alendronate", J Bone Miner Res, 39, pp.473~483 (2024)[DOI]
- Tamayo J, "Reference values for areal bone mineral density among a healthy Mexican population", Salud Publica Mex, 51(Suppl 1), pp.S56~S83 (2009)[DOI]
- Cossio-Bolanos M, "Reference values for bone density and bone mineral content from 5 to 80 years old in a province of Chile", PeerJ, 10, pp.e13092~ (2022)[DOI]
- Weaver CM, "The National Osteoporosis Foundation's position statement on peak bone mass development and lifestyle factors : A systematic review and implementation recommendations", Osteoporos Int, 27, pp.1281~1386 (2016)[DOI]
- Kudlacek S, "Normative data of bone mineral density in an unselected adult Austrian population", Eur J Clin Invest, 33, pp.332~339 (2003)[DOI]
- Noon E, "Significant differences in UK and US female bone density reference ranges", Osteoporos Int, 21, pp.1871~1880 (2010)[DOI]
- Nakavachara P, "A normal reference of bone mineral density(BMD)measured by dual energy X-ray absorptiometry in healthy thai children and adolescents aged 5-18 years : A new reference for Southeast Asian Populations", PLoS One, 9, pp.e97218~ (2014)[DOI]
- Høiberg M, "Population-based reference values for bone mineral density in young men", Osteoporos Int, 18, pp.1507~1514 (2007)[DOI]
- Vega E, "Bone mineral density in osteoporotic and normal women of Buenos Aires", Medicina(B Aires), 53, pp.211~216 (1993)
- Diaz Curiel M, "Study of bone mineral density in lumbar spine and femoral neck in a Spanish population. Multicentre Research Project on Osteoporosis", Osteoporos Int, 7, pp.59~64 (1997)[DOI]
- Guglielmi G, "Age-related changes assessed by peripheral QCT in healthy Italian women", Eur Radiol, 10, pp.609~614 (2000)[DOI]
- Nicks KM, "Three-dimensional structural analysis of the proximal femur in an age-stratified sample of women", Bone, 55, pp.179~188 (2013)[DOI]
- Grampp S, "Quantitative CT assessment of the lumbar spine and radius in patients with osteoporosis", AJR Am J Roentgenol, 167, pp.133~140 (1996)[DOI]
- Nishiyama KK, "Classification of women with and without hip fracture based on quantitative computed tomography and finite element analysis", Osteoporos Int, 25, pp.619~626 (2014)[DOI]
- Löffler MT, "Automatic opportunistic osteoporosis screening in routine CT : Improved prediction of patients with prevalent vertebral fractures compared to DXA", Eur Radiol, 31, pp.6069~6077 (2021)[DOI]
- Löffler MT, "Improved prediction of incident vertebral fractures using opportunistic QCT compared to DXA", Eur Radiol, 29, pp.4980~4989 (2019)[DOI]
- Goel H, "A pilot study comparing daily teriparatide with monthly cycles of teriparatide and raloxifene", Arch Osteoporos, 16, pp.70~ (2021)[DOI]
- Seeman E, "Bone quality--the material and structural basis of bone strength and fragility", N Engl J Med, 354, pp.2250~2261 (2006)[DOI]
- Lotz JC, "Stress distributions within the proximal femur during gait and falls : Implications for osteoporotic fracture", Osteoporos Int, 5, pp.252~261 (1995)[DOI]
- Mayhew PM, "Relation between age, femoral neck cortical stability, and hip fracture risk", Lancet, 366, pp.129~135 (2005)[DOI]
- Bousson V, "Volumetric quantitative computed tomography of the proximal femur : Relationships linking geometric and densitometric variables to bone strength. Role for compact bone", Osteoporos Int, 17, pp.855~864 (2006)[DOI]
- Riggs BL, "Population-based study of age and sex differences in bone volumetric density, size, geometry, and structure at different skeletal sites", J Bone Miner Res, 19, pp.1945~1954 (2004)[DOI]
- Dudle A, "2D-3D reconstruction of the proximal femur from DXA scans : Evaluation of the 3D-Shaper software", Front Bioeng Biotechnol, 11, pp.1111020~ (2023)[DOI]
- O'Rourke D, "Assessment of femoral neck strength and bone mineral density changes following exercise using 3D-DXA images", J Biomech, 119, pp.110315~ (2021)[DOI]
