Effect of Lactobacillus Fermentum as a Probiotic Agent on Bone Health in Postmenopausal Women
2
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Background: Probiotics are live microorganisms that confer health benefits on the host. Many animal studies have shown that among the probiotics, lactobacilli exert favorable effects on bone metabolism. Herein, we report the results of a randomized controlled trial performed to investigate the effect of Lactobacillus fermentum (L. fermentum) SRK414 on bone health in postmenopausal women. Methods: The bone turnover markers (BTMs) and bone mineral density (BMD) in participants in the study group (N=27; mean age, 58.4±3.4 years) and control group (N=26; mean age, 59.5±3.4 years) were compared during a 6-month trial. BTMs were measured at pretrial, 3 months post-trial, and 6 months post-trial, while BMD was measured at pre-trial and 6 months post-trial. Changes in the gut microorganisms were also evaluated. Results: Femur neck BMD showed a significant increase at 6 months post-trial in the study group (P=0.030) but not in the control group. The control group showed a decrease in osteocalcin (OC) levels (P=0.028), whereas the levels in the study group were maintained during the trial period. The change in L. fermentum concentration was significantly correlated with that in OC levels (r=0.386, P= 0.047) in the study group at 3 months post-trial. Conclusions: Probiotic (L. fermentum SRK414) supplementation was found to maintain OC levels and increase femur neck BMD during a 6-month trial in postmenopausal women. Further studies with a larger number of participants and a longer study period are required to increase the utility of probiotics as an alternative to osteoporosis medication
Abstract
Background: Probiotics are live microorganisms that confer health benefits on the host. Many animal studies have shown that among the probiotics, lactobacilli exert favorable effects on bone metabolism. Herein, we report the results of a randomized controlled trial performed to investigate the effect of Lactobacillus fermentum (L. fermentum) SRK414 on bone health in postmenopausal women. Methods: The bone turnover markers (BTMs) and bone mineral density (BMD) in participants in the study group (N=27; mean age, 58.4±3.4 years) and control group (N=26; mean age, 59.5±3.4 years) were compared during a 6-month trial. BTMs were measured at pretrial, 3 months post-trial, and 6 months post-trial, while BMD was measured at pre-trial and 6 months post-trial. Changes in the gut microorganisms were also evaluated. Results: Femur neck BMD showed a significant increase at 6 months post-trial in the study group (P=0.030) but not in the control group. The control group showed a decrease in osteocalcin (OC) levels (P=0.028), whereas the levels in the study group were maintained during the trial period. The change in L. fermentum concentration was significantly correlated with that in OC levels (r=0.386, P= 0.047) in the study group at 3 months post-trial. Conclusions: Probiotic (L. fermentum SRK414) supplementation was found to maintain OC levels and increase femur neck BMD during a 6-month trial in postmenopausal women. Further studies with a larger number of participants and a longer study period are required to increase the utility of probiotics as an alternative to osteoporosis medication
참고문헌 (34)
- Raisz LG, "Pathogenesis of osteoporosis: concepts, conflicts, and prospects", J Clin Invest, 115, pp.3318~3325 (2005)[DOI]
- Pacifici R, "Estrogen deficiency, T cells and bone loss", Cell Immunol, 252, pp.68~80 (2008)[DOI]
- Rizzoli R, "Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis", Calcif Tissue Int, 89, pp.91~104 (2011)[DOI]
- Sanders KM, "Annual high-dose oral vitamin D and falls and fractures in older women : a randomized controlled trial", JAMA, 303, pp.1815~1822 (2010)[DOI]
- O'Brien PE, "Failure to report financial disclosure information in a study of gastric banding in adolescent obesity", JAMA, 303, pp.2357~ (2010)[DOI]
- Bischoff-Ferrari HA, "Monthly high-dose vitamin D treatment for the prevention of functional decline : A randomized clinical trial", JAMA Intern Med, 176, pp.175~183 (2016)[DOI]
- Khaw KT, "Effect of monthly high-dose vitamin D supplementation on falls and non-vertebral fractures: secondary and post-hoc outcomes from the randomised, double-blind, placebo-controlled ViDA trial", Lancet Diabetes Endocrinol, 5, pp.438~447 (2017)[DOI]
- "Guidelines for the evaluation of probiotics in food: Report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food" (2002)[URL]
- Bron PA, "Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa", Nat Rev Microbiol, 10, pp.66~78 (2011)[DOI]
- Ohlsson C, "Effects of the gut microbiota on bone mass", Trends Endocrinol Metab, 26, pp.69~74 (2015)[DOI]
- Rizzoli R, "Effects of fermented milk products on bone", Calcif Tissue Int, 102, pp.489~500 (2018)[DOI]
- McCabe LR, "Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice", J Cell Physiol, 228, pp.1793~1798 (2013)[DOI]
- Lee CS, "Anti-inflammatory and anti-osteoporotic potential of Lactobacillus plantarum A41 and L. fermentum SRK414 as probiotics", Probiotics Antimicrob Proteins, 12, pp.623~634 (2020)[DOI]
- Johnston CC, "Heterogeneity of fracture syndromes in postmenopausal women", J Clin Endocrinol Metab, 61, pp.551~556 (1985)[DOI]
- Florschutz AV, "Femoral neck fractures : current management", J Orthop Trauma, 29, pp.121~129 (2015)[DOI]
- Kim JG, "Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats", Int Dairy J, 19, pp.690~695 (2009)
- Jafarnejad S, "controlled trial", J Am Coll Nutr, 36, pp.497~506 (2017)[DOI]
- Lambert MNT, "Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women : a randomized controlled trial", Am J Clin Nutr, 106, pp.909~920 (2017)[DOI]
- Jansson PA, "Probiotic treatment using a mix of three Lactobacillus strains for lumbar spine bone loss in postmenopausal women: a randomised, double-blind, placebo-controlled, multicentre trial", Lancet Rheumatol, 1, pp.E154~E62 (2019)
- Morato-Martínez M, "A dairy product to reconstitute enriched with bioactive nutrients stops bone loss in high-risk menopausal women without pharmacological treatment", Nutrients, 12 (2020)[DOI]
- Szulc P, "Biochemical markers of bone turnover : potential use in the investigation and management of postmenopausal osteoporosis", Osteoporos Int, 19, pp.1683~1704 (2008)[DOI]
- Komori T, "Functions of osteocalcin in bone, pancreas, testis, and muscle", Int J Mol Sci, 21 (2020)[DOI]
- DeSelm CJ, "IL-17 mediates estrogen-deficient osteoporosis in an Act1-dependent manner", J Cell Biochem, 113, pp.2895~2902 (2012)[DOI]
- Kitaura H, "Immunological reaction in TNF-α-mediated osteoclast formation and bone resorption in vitro and in vivo", Clin Dev Immunol, 2013, pp.181849~ (2013)[DOI]
- Humphrey MB, "A comprehensive review of immunoreceptor regulation of osteoclasts", Clin Rev Allergy Immunol, 51, pp.48~58 (2016)[DOI]
- Ohlsson C, "Probiotics protect mice from ovariectomy-induced cortical bone loss", PLoS One, 9, pp.e92368~ (2014)[DOI]
- Dawson-Hughes B, "Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older", N Engl J Med, 337, pp.670~676 (1997)[DOI]
- Chiang SS, "Beneficial effects of phytoestrogens and their metabolites produced by intestinal microflora on bone health", Appl Microbiol Biotechnol, 97, pp.1489~1500 (2013)[DOI]
- Ray NF, "Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995 : report from the National Osteoporosis Foundation", J Bone Miner Res, 12, pp.24~35 (1997)[DOI]
- Burge R, "Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025", J Bone Miner Res, 22, pp.465~475 (2007)[DOI]
- Tarride JE, "Loss of health related quality of life following low-trauma fractures in the elderly", BMC Geriatr, 16, pp.84~ (2016)[DOI]
- Fatoye F, "Real-world persistence and adherence with oral bisphosphonates for osteoporosis : a systematic review", BMJ Open, 9, pp.e027049~ (2019)[DOI]
- Modi A, "Osteoporotic fracture rate among women with at least 1 year of adherence to osteoporosis treatment", Curr Med Res Opin, 31, pp.767~777 (2015)[DOI]
- Siris ES, "Adherence to bisphosphonate therapy and fracture rates in osteoporotic women : relationship to vertebral and nonvertebral fractures from 2 US claims databases", Mayo Clin Proc, 81, pp.1013~1022 (2006)[DOI]
