아젤라인산을 함유한 여드름용 화장품 제형의 안정성
Stability of Acne Cosmetics Containing Azelaic Acid
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High concentration of azelaic acid which is non-soluble to water, oil and ethanol was studied. The cosolvents were used to raise aqueous solution concentration and solubilizing agents were used to prevent from recrystallizing. And the neutralizers were used to raise stability of aqueous solution neutralized as rate of equivalent. Polysorbate 80, polysorbate 60, and lysolecithin were used for solubilizing agents and triethanolamine, arginine, and sodium hydroxide were used for neutralizer. The compositions of azelaic acid were 16% for azelaic acid, 12% for lysolecithin, 37% for propylene glycol, 35% for water, respectively. The solubility of azelaic acid to water was increased to 16% from 0.2%. And its solubility was increased 11% from 0.2% when propylene glycol as cosolvent was used and surfactant was not. Also, solubility for azelaic acid salts were increased in 35% and 30%, respectively when triethanolamine and arginine as rate of equivalent of azelaic acid were used to control pH. The solubilities of surfactant, cosolvent and neutralizer which affected product stability were as follows; in case of the surfactants 25% for lysolecithin, 24% for polysorbate 80 and 23% for polysorbate 60. In case of cosolvents, 12% for propylene glycol, 14% for polyethylene glycol, 2% for glycerine and 0.2% for sorbitol. In case of the neutralizers, the solubilities of azelaic acid increased with sodium hydroxide, arginine and triethanolamine in sequence.
Abstract
High concentration of azelaic acid which is non-soluble to water, oil and ethanol was studied. The cosolvents were used to raise aqueous solution concentration and solubilizing agents were used to prevent from recrystallizing. And the neutralizers were used to raise stability of aqueous solution neutralized as rate of equivalent. Polysorbate 80, polysorbate 60, and lysolecithin were used for solubilizing agents and triethanolamine, arginine, and sodium hydroxide were used for neutralizer. The compositions of azelaic acid were 16% for azelaic acid, 12% for lysolecithin, 37% for propylene glycol, 35% for water, respectively. The solubility of azelaic acid to water was increased to 16% from 0.2%. And its solubility was increased 11% from 0.2% when propylene glycol as cosolvent was used and surfactant was not. Also, solubility for azelaic acid salts were increased in 35% and 30%, respectively when triethanolamine and arginine as rate of equivalent of azelaic acid were used to control pH. The solubilities of surfactant, cosolvent and neutralizer which affected product stability were as follows; in case of the surfactants 25% for lysolecithin, 24% for polysorbate 80 and 23% for polysorbate 60. In case of cosolvents, 12% for propylene glycol, 14% for polyethylene glycol, 2% for glycerine and 0.2% for sorbitol. In case of the neutralizers, the solubilities of azelaic acid increased with sodium hydroxide, arginine and triethanolamine in sequence.
참고문헌 (15)
- Basset OB, "A comparative study of tea tree oil versus benzoyl peroxide in the treatment of acne", Med J Aust, 153, pp.455~458 (1990)
- Christiansen JV, "Topical tretinoin, Vitamin A acid in acne vulgaris", Dermatologica, 148, pp.82~89 (1974)
- David C, "Management of acne", J Family Practice, 52, pp.43~51 (2003)
- Dobson RL, "Topical erythromycin solution in acne", J Am Acad Dermatol, 3, pp.478~482 (1980)
- Iraji F, "Efficacy of topical azelaic acid gel in the treatment of mild-moderate acne vulgaris", Indian J Dermatol, 73, pp.94~96 (2007)
- Hughes BR, "A double-blind evaluation of topical isotretinoin 0.05%, benzoyl peroxide gel 5% and placebo in patients with acne", Clin Exp Dermatol, 17, pp.165~168 (1992)
- Katsambas A, "Clinical studies of 20% azelaic acid cream in the treatment of acne vulgaris. Comparison with vehicle and topical tretinoin", Acta Derm Venereol Suppl, 143, pp.35~39 (1989)
- Leyden JJ, "Therapy for acne vulgaris", N Engl J Med, 336, pp.1156~1162 (1997)
- Metin O, "Clinical efficacy of topical clindamycin phosphate and azelaic acid on acne vulgaris and emergence of resistant coagulase-negative Staphylococci", Turk J Med Sci, 30, pp.483~487 (2000)
- Mills OH, "Comparing 2.5%, 5%, and 10% benzoyl peroxide on inflammatory acne vulgaris", Int J Dermatol, 25, pp.664~667 (1986)
- Passi S, "Mechanism of azelaic acid action in acne", Ital Dermatol Venereol, 124, pp.455~463 (1989)
- Pedace FJ, "Topical tretinoic acid in acne vulgaris", Br J Dermatol, 84, pp.465~469 (1971)
- Pochi PE, "Erythromycin 2 percent gel in the treatmentof acne vulgaris", Cutis, 41, pp.132~136 (1988)
- Thiaboutot DM, "An overview of acne and its treatment", Cutis, 57, pp.8~12 (1996)
- Worret WI, "Acne therapy with topical benzoyl peroxide,antibiotics and azelaic acid", J Dtsch Dermatol Ges, 4, pp.43~51 (2003)