애기똥풀(Chelidonium majus var asiaticum) 추출물의 생리활성 연구
The Study of Physiological Activities from Chelidonium majus var asiaticum Extract
1
조회
0
다운로드
9
인용
0
참고문헌
키워드
초록
This research is to useful physiological activities data of the aerial part of the Chelidonium majus var asiaticum, analyzed contents of polyphenol and flavonoid compound, nitrite scavenging, superoxide dismutatse (SOD)-like activity, electron donating, tyrosinase inhibition and xanthine oxidase inhibition. The RW (Reflux water extract of C. majus var asiaticum) showed the highest value of nitrite scavenging ability of 73.13% at pH 1.2, 2.0 mg/mL. The RE (Reflux 70% ethanol extract of C. majus var asiaticum) showed the highest of SOD-like activity of 78.67% at 2.0 mg/mL and electron donating ability of 86.07% at 0.3 mg/mL. The tyrosinase inhibitory of RW was 38.71%, it was significantly 2.5 higher compared to the RE (15.18%). The xanthine oxidase inhibitory of RW and RE were over 97% at 2.0 mg/mL. The both extracts were higher than ascorbic acid (55.36%) at 0.05 mg/mL. This suggests that C. majus can be useful materials as functional healthy product, medicine, and cosmetic products.
Abstract
This research is to useful physiological activities data of the aerial part of the Chelidonium majus var asiaticum, analyzed contents of polyphenol and flavonoid compound, nitrite scavenging, superoxide dismutatse (SOD)-like activity, electron donating, tyrosinase inhibition and xanthine oxidase inhibition. The RW (Reflux water extract of C. majus var asiaticum) showed the highest value of nitrite scavenging ability of 73.13% at pH 1.2, 2.0 mg/mL. The RE (Reflux 70% ethanol extract of C. majus var asiaticum) showed the highest of SOD-like activity of 78.67% at 2.0 mg/mL and electron donating ability of 86.07% at 0.3 mg/mL. The tyrosinase inhibitory of RW was 38.71%, it was significantly 2.5 higher compared to the RE (15.18%). The xanthine oxidase inhibitory of RW and RE were over 97% at 2.0 mg/mL. The both extracts were higher than ascorbic acid (55.36%) at 0.05 mg/mL. This suggests that C. majus can be useful materials as functional healthy product, medicine, and cosmetic products.
참고문헌 (38)
- 김창민, "완역중약대사전", pp.2032~2035 (1998), 정담
- AOAC, "Official method of analysis. 18th ed", Association of official analytical chemists, 21~22 (2005)
- Bell AA, "Biosynthesis and melanin", Ann. Rev. Phytophathol, 24, pp.411~451 (1986)
- Blois, MS, "Antioxidant determination by the use of a stable free radical", Nature, 181, pp.1199~1200 (1958)
- Branen AL, "Toxicological and biochemistry of butylated hydroxyanisole and butylated hydroxytoluene", JAOCS, 52, pp.59~63 (1975)
- 최복동, "국내산과 중국산 자화지정(Viola mandshurica) 추출물의 생리활성", 한국식품영양과학회지, 37(9), pp.1101~1108 (2008), 한국식품영양과학회
- Choi BW, "Screening of the tyrosinase inhibitors from marine algae and medicinal plants", Kor J Pharmacogn, 29, pp.237~242 (1998)
- 최두호, "白屈菜 추출물의 피지생성 억제효과", 동의생리병리학회지, 20(6), pp.1561~1566 (2006), 대한동의병리학회
- Colr MM, "Antioxidant activity of tocopherols and ascrobyl palmitate and their mode of action", JAOCS, 51, pp.156~325 (1974)
- Cooney RW, "N-nitrosation and N-nitration of morphpline by notrogen dioxide in aqueous solution, effect of vanillin and related phenols", J Agric Food Chem, 35, pp.789~793 (1987)
- Freile ML, "Antimicrobial activity of aqueous extracts and of berberine isolated from Berberis heterophylla", Fitoterapia, 74, pp.702~709 (2003)
- 한은경, "민들레의 부위별 에탄올 추출물의 항산화 활성", 한국식품영양과학회지, 40(1), pp.56~62 (2011), 한국식품영양과학회
- Hertong MGL, "Content of potentially anticarinogenic flavonoids of 28 vegetables and 9 fruits commonly consumed in the Netherlands", J Agirc Food Chem, 40, pp.2379~2383 (1992)
- 이재성, "덩굴차(Gynostemma pentaphyllum Makino) 추출물의 항산화 효과", 한국식품과학회지, 39(4), pp.447~451 (2007), 한국식품과학회
- Ivengar R, "Antibrowning agents: alternatives to the use of sulfites in foods", Trends Food Sci Technol, 3, pp.60~63 (1992)
- Kato H, "Inhibition of nitrosamine formation by nondialyzable melanoidins", Agric Biol Chen, 51, pp.1333~1338 (1987)
- 김은영, "항산화활성을 나타내는 약용식물 소재 탐색", 한국식품과학회지, 36(2), pp.333~338 (2004), 한국식품과학회
- 김미향, "차조기(Perilla frutescens var. acuta kudo) 잎의 물과 에탄올 추출물의 항산화 활성", Journal of the Korean Society for Applied Biological Chemistry, 50(4), pp.327~333 (2007), 한국응용생명화학회
- Kim MS, "Alkaloidal components of chelidonii fructus", Kor J Pharmacogn, 31, pp.390~393 (2000)
- Lee MS, "In antioxidant cosmetics subject matter of Phellinus linteus and Mognolia biondii complex extracts skin care effect", J Kor Soc Esthe and Cosm, 4, pp.77~85 (2009)
- 이승욱, "울릉도산 산채류 추출물의 총 폴리페놀 함량 및 항산화 활성", 한국식품과학회지, 37(2), pp.233~240 (2005), 한국식품과학회
- Lee TB, "Illustrated Flora of Korea. 5th ed", pp.381~ (1993), Hyangmoonsa
- 이양숙, "구릿대 잎 추출물의 항산화 효과 및 생리활성", 한국식품저장유통학회지, 14(1), pp.78~86 (2007), 한국식품저장유통학회
- 이양숙, "가죽나무(Ailanthus altissima) 열수 추출물의 생리활성", 한국식품저장유통학회지, 14(2), pp.170~176 (2007), 한국식품저장유통학회
- Lenfeld J, "Antiinflammatory activity of quatemary benzophenanthridine alkaloids from Chelidonium majus", Planta Med, 43, pp.161~165 (1981)
- 임정대, "한국산 약용식물로부터의 SOD 활성 및 Phenolic Compounds 함량 비교", 한국약용작물학회지, 12(3), pp.191~202 (2004), 한국약용작물학회
- Marklund S, "Involvement of superoxide amino radical in the oxidation of pyrogallol and a convenient assay for superoxide dismutase", Eur J Biochem, 47, pp.468~474 (1975)
- 문지숙, "약용식품 추출에 대한 항산화성과 알코올 탈수소효소 저해성 연구", 한국식품저장유통학회지, 11(2), pp.201~206 (2004), 한국식품저장유통학회
- 김선재, "약용식품 추출에 대한 항미생물 활성 검색과 폴리페놀 함량", 한국식품저장유통학회지, 11(2), pp.207~213 (2004), 한국식품저장유통학회
- Nieva Moreno MI, "Comparison of the free radical-scavenging activity of propolis from several regions of Argentina", J Ethnopharmacol, 71, pp.109~114 (2000)
- Pryor WA, "Oxy-radicals and related species : their formation, lifetimes, and reactions", Annu. Rev Physio, 48, pp.657~667 (1986)
- 노성수, "白屈菜가 천식유발 생쥐의 폐조직에서 호산구 증식과 면역 세포 활성화에 미치는 영향", 대한본초학회지, 23(2), pp.99~109 (2008), 대한본초학회
- Stirpe F, "The regulation of rat liver xanthine oxidase", J Biol Chem, 244, pp.3855~3861 (1969)
- Storch I, "Detergent-amplified chemiluminescence of lucigenin for determination of superoxide amino production by NADPH oxidase and xanthine oxidase", Anal Biochem, 169, pp.262~267 (1988)
- Yagi A, "Inhibition of mushroom-tyrosinase by aloe extract", Planta Medica, 53, pp.517~519 (1987)
- Yang MS, "Screening of domestic plants with antibacterial activity", Agricultural Chem Biotech, 38, pp.584~589 (1995)
- Yeo SG, "Inhibition of xanthine oxidase by tea extracts from green tea, oolong tea and black tea", J Korea Soc Food Sci Nutr, 24, pp.154~159 (1995)
- Zhao RJ, "Inhibitory effects of Chilidonii herba water extract on production of nitric oxide, expression of iNOS and COX-2 in lipopolysaccharide-activated Raw 264.7 cell", Kor J Ori Med Prescription, 12, pp.163~173 (2004)