PPG-β-cyclodextrin에 의한 Aesculetin의 분자 캡슐화와 화장품에의 적용
Molecular Capsulation of Aesculetin by Using PPG-β-Cyclodextrin and Its Application to Cosmetics
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Aesculetin, a derivative of coumarin, is a compound known as a scavenger of reactive oxygen species (ROS). Aesculetin is also known to have various inhibition effects for cyclooxygenase (COX) as well as matrix metalloproteinases (MMPs). However, limited solubility and labile color stability were the main problems in cosmetic formulation. Therefore, the purpose of this study was to improve limited solubility and color stability using a molecular capsulation technique. PPG-β-CD, polypropylene glycol-β-cyclodextrin, can form non-covalent inclusion complexes by molecular capsulation. Inclusion complex by PPG-β-CD is a unique approach to molecular capsulation based on molecular selectivity. In this study, PPG-β-CD was prepared by substitution of the hydroxyl groups under high pressure conditions. Fourier-transformed infrared spectroscopy (FT-IR) was used for determination of the chemical structure of PPG-β-CD. A deep freezing method under high vacuum was used for molecular capsulation. UV/VIS spectroscopy, scanning electron microscope (SEM), and X-ray diffraction (XRD) were used for structural confirmation of the molecular capsule. UV/VIS spectroscopy showed a bath-chromic shift. SEM showed a swollen shape and XRD showed the non-crystalline structure of aesculetin. These findings indicate that molecular capsulation was completed between aesculetin and PPG-β-CD. The molecular capsulation between PPG-β-CD and aesculatin enhanced the solubility and color stability of aesculetin in formulation of skin care cosmetics. The results suggested that by use of PPG-β-CD the molecular capsule could be a multi-functional ingredient for use in cosmetic products.
Abstract
Aesculetin, a derivative of coumarin, is a compound known as a scavenger of reactive oxygen species (ROS). Aesculetin is also known to have various inhibition effects for cyclooxygenase (COX) as well as matrix metalloproteinases (MMPs). However, limited solubility and labile color stability were the main problems in cosmetic formulation. Therefore, the purpose of this study was to improve limited solubility and color stability using a molecular capsulation technique. PPG-β-CD, polypropylene glycol-β-cyclodextrin, can form non-covalent inclusion complexes by molecular capsulation. Inclusion complex by PPG-β-CD is a unique approach to molecular capsulation based on molecular selectivity. In this study, PPG-β-CD was prepared by substitution of the hydroxyl groups under high pressure conditions. Fourier-transformed infrared spectroscopy (FT-IR) was used for determination of the chemical structure of PPG-β-CD. A deep freezing method under high vacuum was used for molecular capsulation. UV/VIS spectroscopy, scanning electron microscope (SEM), and X-ray diffraction (XRD) were used for structural confirmation of the molecular capsule. UV/VIS spectroscopy showed a bath-chromic shift. SEM showed a swollen shape and XRD showed the non-crystalline structure of aesculetin. These findings indicate that molecular capsulation was completed between aesculetin and PPG-β-CD. The molecular capsulation between PPG-β-CD and aesculatin enhanced the solubility and color stability of aesculetin in formulation of skin care cosmetics. The results suggested that by use of PPG-β-CD the molecular capsule could be a multi-functional ingredient for use in cosmetic products.
참고문헌 (20)
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