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도인 정유의 멜라닌 생성 억제 및 자외선 차단 효과

Anti-melanogenic and UV-blocking Effects of Peach Kernel Essential Oil

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초록

This study investigated the anti-melanogenic and UV-blocking effects of hydro-distilled essential oil extracted from peach kernels. Peach kernel essential oil showed significant inhibitory actions against both the monophenolase (IC50=14.4 μg/mL) and diphenolase (IC50=47.1 μg/mL) activities of mushroom tyrosinase. This essential oil also inhibited cell-free tyrosinase activity of murine melanoma B16F10 cells in a dose-dependent manner. However, this essential oil did not exhibit cytotoxicity to B16F10 cells up to 100 μg/mL. The essential oil treatment resulted in a significant decrease in the melanin content of α-MSH-stimulated B16F10 cells. UV spectrophotometry was used to determine the UV-blocking effect of the oil. The essential oil showed an in vitro sun protecting factor (SPF) value of 10.112. This study suggests that peach kernel essential oil can be applied as a novel natural anti-melanogenic agent that also blocks UV.

Abstract

This study investigated the anti-melanogenic and UV-blocking effects of hydro-distilled essential oil extracted from peach kernels. Peach kernel essential oil showed significant inhibitory actions against both the monophenolase (IC50=14.4 μg/mL) and diphenolase (IC50=47.1 μg/mL) activities of mushroom tyrosinase. This essential oil also inhibited cell-free tyrosinase activity of murine melanoma B16F10 cells in a dose-dependent manner. However, this essential oil did not exhibit cytotoxicity to B16F10 cells up to 100 μg/mL. The essential oil treatment resulted in a significant decrease in the melanin content of α-MSH-stimulated B16F10 cells. UV spectrophotometry was used to determine the UV-blocking effect of the oil. The essential oil showed an in vitro sun protecting factor (SPF) value of 10.112. This study suggests that peach kernel essential oil can be applied as a novel natural anti-melanogenic agent that also blocks UV.

참고문헌 (50)

  1. Adewinogo SO, "Chemical composition and cosmeceutical potential of the essential oil of Oncosiphon suffruticosum(L. )Källersjö", Plants, 10, pp.1315~ (2021)[DOI]
  2. Agunbiade M, "Application of bacterial tyrosinases in organic synthesis", World J Microbiol Biotechnol, 38, pp.2~ (2022)[DOI]
  3. Ahn JH, "Inhibitory effects of apricot seed essential oil on melanogenesis", Kor J Aesthet Cosmetol, 12, pp.677~683 (2014)
  4. Andersen A, "Final report on the safety assessment of benzaldehyde", Int J Toxicol, 25(Suppl. 1), pp.11~27 (2006)[DOI]
  5. Brenner M, "The protective role of melanin against UV damage in human skin", Photochem Photobiol, 84, pp.539~549 (2008)[DOI]
  6. Cassiem W, "The anti-proliferative effect of apricot and peach kernel extracts on human colon cancer cells in vitro", BMC Complement Altern Med, 19, pp.32~ (2019)[DOI]
  7. Chang TS, "An updated review of tyrosinase inhibitors", Int J Mol Sci, 10, pp.2440~2475 (2009)[DOI]
  8. Draelos ZD, "Skin lightening preparations and the hydroquinone controversy", Dermatol Ther, 20, pp.308~313 (2007)[DOI]
  9. Editorial committee of Korean medical institute of dermatology & aesthetics, "Introduction to Korean dermatology & aesthetics", Korean medical institute of dermatology & aesthetics, 85~86 (2004)
  10. Fang C, "Persicae Semen ameliorated acute myocardial ischemia in rats by regulating the PI3K", Akt, J Funct Foods, pp.2024, 120[DOI]
  11. Fukuda T, "Anti-tumor promoting effect of glycosides from Prunus persica seeds", Biol Pharm Bull, 26, pp.271~273 (2003)[DOI]
  12. Geng H, "Extraction, chemical composition, and antifungal activity of essential oil of bitter almond", Int J Mol Sci, 17, pp.1421~ (2016)[DOI]
  13. Hafidi Z, "Micellar catalysis strategy of cross-condensation reaction: the effect of polar heads on the catalytic properties of aminoalcohol-based surfactants", Catal Lett, 150, pp.1309~1324 (2020)[DOI]
  14. Halder RM, "Ethnic skin disorders overview", J Am Acad Dermatol, 48, pp.S143~S148 (2003)[DOI]
  15. Hao E, "Peach kernel oil downregulates expression of tissue factor and reduces atherosclerosis in ApoE knockout mice", Int J Mol Sci, 20, pp.405~ (2019)[DOI]
  16. Herbology editorial committee of Korean medicine schools, "Herbology", pp.465~466 (2004), Young-Lim Press
  17. Hollinger JC, "Are natural ingredients effective in the management of hyperpigmentation? a systematic review", J Clin Aesthetic Dermatol, 11, pp.28~37 (2018)
  18. Im S, "Increased expression of α-melanocyte-stimulating hormone in the lesional skin of melasma", Br J Dermatol, 146, pp.165~167 (2002)[DOI]
  19. Imam S, "In-vitro evaluation of sun protection factor of a cream formulation prepared from extracts of Musa accuminata(L. ), Psidium gujava(L. )and Pyrus communis(L. )", Asian J Pharm Clin Res, 8, pp.234~237 (2015)
  20. Joe WA, "Cosmeceutical activities of Persicae semen", J Korean Soc Appl Biol Chem, 49, pp.135~139 (2006)
  21. Joe WA, "Cosmeceutical activities and anti-inlammatory effects of shell from Pericae semen", Kor J Herbology, 21, pp.87~93 (2006)
  22. Jun JY, "Persicae Semen promotes bone union in rat fractures by stimulating osteoblastogenesis through BMP-2 and Wnt signaling", Int J Mol Sci, 24, pp.7388~ (2023)[DOI]
  23. Jung KM, "In vitro correlation between anti-inflammatory and anti-oxidant effects of stone and seed of peaches cultivars", Korean J Food Preserv, 25, pp.90~97 (2018)[DOI]
  24. Kaidbey KH, "Photoprotection by melanin-a comparison of black and Caucasian skin", J Am Acad Dermatol, 1, pp.249~260 (1979)[DOI]
  25. Kang WH, "histopathological characteristics in 56 Korean patients", Br J Dermatol, 146, pp.228~237 (2002)[DOI]
  26. Kaur CD, "In vitro sun protection factor determination of herbal oils used in cosmetics", Pharmacognosy Res, 2, pp.22~25 (2010)[DOI]
  27. Kim M, "Rhododenol activates melanocytes and induces morphological alteration at sub-cytotoxic levels", Int J Mol Sci, 20, pp.5665~ (2019)[DOI]
  28. Kim SW, "Effect of Persicae semen for atopic dermatitis skin tissue and regulate to inflammation mediator in serum", Korea J Herbol, 35, pp.51~60 (2020)[DOI]
  29. Kwon HY, "Apoptosis induction of Persicae semen extract in human promyelocytic leukemia(HL-60)cells", Arch Pharm Res, 26, pp.157~161 (2003)[DOI]
  30. Lee H, "Chemical composition and antimicrobial activity of the essential oil of apricot seed", Phytother Res, 28, pp.1867~1872 (2014)[DOI]
  31. Lee JW, "Effect of the water extract of Persicae Semen on promotion of axon regeneration", Korean J Orient Physiol Pathol, 21, pp.145~152 (2007)
  32. Liu Y, "Traditional use, phytochemistry, pharmacology, toxicology and clinical applications of Persicae Semen : a review", Chin J Integr Med (2024)[DOI]
  33. Lohani A, "Cosmeceutical potential of geranium and calendula essential oil: determination of antioxidant activity and in vitro sun protection factor", J Cosmet Dermatol, 18, pp.1~8 (2018)[DOI]
  34. Mansuri R, "Potential of natural compounds as sunscreen agents", Pharmacogn Rev, 15, pp.47~56 (2021)[DOI]
  35. Matsuda H, "Studies of cuticle drugs from natural sources. II. inhibitory effects of Prunus plants on melanin biosynthesis", Biol Pharm Bull, 17, pp.1417~1420 (1994)[DOI]
  36. Momtaz S, "Tyrosinase inhibition by extracts and constituents of Sideroxylon inerme L. stem bark, used in South Africa for skin lightening", J Ethnopharmacol, 119, pp.507~512 (2008)[DOI]
  37. Morocho-Jácome A, "In vivo SPF from multifunctional sunscreen systems developed with natural compounds—a review", J Cosmet Dermatol, 20, pp.729~737 (2020)[DOI]
  38. Na JX, "Hepatoprotective and antifibrotic effects of extracts from Persicae Semen", Korean J Orient Med Pres, 12, pp.109~117 (2004)
  39. Nautiyal A, "Management of hyperpigmentation: current treatments and emerging therapies", Pigment Cell Melanoma Res, 34, pp.1000~1014 (2021)[DOI]
  40. Park HJ, "Inhibitory effect of Prunus persica flesh extract(PPFE)on melanogenesis through the microphthalmia-associated transcription factor(MITF)-mediated pathway", Nat Prod Sci, 17, pp.26~32 (2011)
  41. Rehman S, "Phytochemical screening and protective effects of Prunus Persica seeds extract on carbon tetrachloride-induced hepatic injury in rats", Curr Pharm Biotechnol, 23, pp.158~170 (2022)[DOI]
  42. Rolfe HM, "A review of nicotinamide: treatment of skin diseases and potential side effects", J Cosmet Dermatol, 13, pp.324~328 (2014)[DOI]
  43. Sarkar R, "Cosmeceuticals for hyperpigmentation : what is available?", J Cutan Aesthetic Surg, 6, pp.4~11 (2013)[DOI]
  44. Song MY, "Neuroprotective effect of Semen Persicae in middle cerebral artery occlusion rats", J Korean Med, 30, pp.117~126 (2009)
  45. Sugimoto K, "Syntheses of arbutin-α-glycosides and a comparison of their inhibitory effects with those of α-arbutin and arbutin on human tyrosinase", Chem Pharm Bull, 51, pp.798~801 (2003)[DOI]
  46. Wu H, "Essential oil extracted from peach(Prunus persica)kernel and its physicochemical and antioxidant properties", LWT-Food Sci Technol, 44, pp.2032~2039 (2011)[DOI]
  47. Yamamoto K, "Antimutagenic substances in the Armeniacae semen and Persicae semen", Yakugaku Zasshi J Pharm Soc Jpn, 112, pp.934~939 (1992)[DOI]
  48. Yang J, "Antioxidant activity and preclinical safety of Semen persicae extract", Int J Mol Sci, 25, pp.8580~ (2024)[DOI]
  49. Yang NY, "Antithrombotic lipids from Semen Persicae", Nat Prod Res, 25, pp.1650~1656 (2011)[DOI]
  50. Zhao X, "Antioxidative activity of methyl amygdalinate from the seeds of Prunus persica and neuroprotective effects on Aβ 1–42-induced neurodegeneration models", RSC Adv, 6, pp.93794~93800 (2016)[DOI]

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