Recombinant human bone morphogenetic protein-2와 2가지 scaffold를 이용한 골이식술: 증례연구
Bone graft using two types of scaffolds and recombinant human bone morphogenetic protein-2: Case series study
0
조회
0
다운로드
4
인용
0
참고문헌
키워드
초록
The purpose of this study was to evaluate clinical outcome when hydroxyapatite (HA) or demineralized dentin matrix (DDM) and recombinant human bone morphogenetic protein-2 (rhBMP-2) were used together. Bone graft was performed in eight patients using rhBMP-2 and HA or DDM scaffolds. Scaffolds were soaked with 0.5 mg/0.5 mL of rhBMP-2 solution for 10 minutes. Short-term clinical outcome was evaluated using periodic follow-up and radiographic examination. Favorable bony healing was obtained in all cases without any severe complications. Successful prosthetic treatment was completed without any osseointegration failure. In this case series study, rhBMP-2 combined with HA or DDM scaffolds can be used for bone graft procedures such as guided bone regeneration.
Abstract
The purpose of this study was to evaluate clinical outcome when hydroxyapatite (HA) or demineralized dentin matrix (DDM) and recombinant human bone morphogenetic protein-2 (rhBMP-2) were used together. Bone graft was performed in eight patients using rhBMP-2 and HA or DDM scaffolds. Scaffolds were soaked with 0.5 mg/0.5 mL of rhBMP-2 solution for 10 minutes. Short-term clinical outcome was evaluated using periodic follow-up and radiographic examination. Favorable bony healing was obtained in all cases without any severe complications. Successful prosthetic treatment was completed without any osseointegration failure. In this case series study, rhBMP-2 combined with HA or DDM scaffolds can be used for bone graft procedures such as guided bone regeneration.
참고문헌 (37)
- 박슬지, "골유도재생술과 동시에 식립한 임플란트의 변연골 흡수량에 대한 후향적 고찰", Maxillofacial Plastic Reconstructive Surgery, 34(6), pp.440~448 (2012), 대한악안면성형재건외과학회
- 한민우, "자가치아 뼈 이식재의 유용성에 관한 임상적 연구", Maxillofacial Plastic Reconstructive Surgery, 35(4), pp.221~226 (2013), 대한악안면성형재건외과학회
- 황성택, "생체활성 유기물로 표면이 개질된 임플란트 개발 추이 분석 연구", 대한치과보철학회지, 49(03), pp.254~262 (2011), 대한치과보철학회
- Cheng H, "Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs)", J Bone Joint Surg Am, 85, pp.1544~1552 (2003)
- Boyne PJ, "A feasibility study evaluating rhBMP-2", absorbable collagen sponge for maxillary sinus floor augmentation, 1997, pp.17, 11~25
- Hanisch O, "Bone formation and reosseointegration in peri-implantitis defects following surgical implantation of rhBMP-2", Int J Oral Maxillofac Implants, 12, pp.604~610 (1997)
- Howell TH, "A feasibility study evaluating rhBMP-2", absorbable collagen sponge device for local alveolar ridge preservation or augmentation, 1997, pp.17, 124~139
- Sigurdsson TJ, "Periodontal repair in dogs: evaluation of rhBMP-2 carriers", Int J Periodontics Restorative Dent, 16, pp.524~537 (1996)
- Urist MR, "Bone: formation by autoinduction", Science, 150, pp.893~899 (1965)
- Wozney JM, "Novel regulators of bone formation: molecular clones and activities", Science, 242, pp.1528~1534 (1988)
- Urist MR, "Inductive substrates for bone formation", Clin Orthop Relat Res, 59, pp.59~96 (1968)
- Yeomans JD, "Bone induction by decalcied dentine implanted into oral, osseous and muscle tissues", Arch Oral Biol, 12, pp.999~1008 (1967)
- 김선종, "Effects of Polycaprolactone-Tricalcium Phosphate, Recombinant Human Bone Morphogenetic Protein-2 and Dog Mesenchymal Stem Cells on Bone Formation: Pilot Study in Dogs", Yonsei Medical Journal, 50(6), pp.825~831 (2009), 연세대학교의과대학
- Lee JH, "The induction of bone formation in rat calvarial defects and subcutaneous tissues by recombinant human BMP-2, produced in Escherichia coli", Biomaterials, 31, pp.3512~3519 (2010)
- Yasko AW, "The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats", J Bone Joint Surg Am, 74, pp.659~670 (1992)
- Lindsay S. Karfeld-Sulzer, "Biomaterial development for oral and maxillofacial bone regeneration", 대한구강악안면외과학회지, 38(5), pp.264~270 (2012), 대한구강악안면외과학회
- Jung RE, "Bone morphogenetic protein-2 enhances bone formation when delivered by a synthetic matrix containing hydroxyapatite", tricalciumphosphate, 2008, pp.19, 188~195
- Boerckel JD, "Effects of protein dose and delivery system on BMP-mediated bone regeneration", Biomaterials, 32, pp.5241~5251 (2011)
- Herford AS, "Reconstruction of mandibular conti-nuity defects with bone morphogenetic protein-2 (rhBMP-2)", J Oral Maxillofac Surg, 66, pp.616~624 (2008)
- Murata M, "Human acid-insoluble dentin with BMP-2 accelerates bone-induction in subcutaneous and intramuscular tissues", J Ceram Soc JPN, 118, pp.438~441 (2010)
- Ike M, "Recycled dentin root matrix for a carrier of recombinant human bone morphogenetic protein", J Oral Implantol, 24, pp.124~132 (1998)
- Saito T, "Effect of phosph-ophoryn on rhBMP-2-induced bone formation", Arch Oral Biol, 49, pp.239~243 (2004)
- Yagihashi K, "Demineralized dentin matrix acts as a scaffold for repair of articular cartilage defects", Calcif Tissue Int, 84, pp.210~220 (2009)
- Murata M, "Bone engineering using human demineralized dentin matrix and recombinant human BMP-2", J Hard Tissue Biol, 14, pp.80~81 (2005)
- Masaru Murata, "Biochemical and histo-morphometrical analyses of bone and cartilage induced by human decalcified dentin matrix and BMP-2", Oral Biology Research, 35(1), pp.9~14 (2011), 구강생물학연구소
- Murata M, "Biomaterials-physics and chemistry", pp.127~140 (2011), Croatia
- Murata M, "Acid-insoluble human dentin as carrier material for recombinant human BMP-2", J Biomed Mater Res A, 100, pp.571~577 (2012)
- Jung RE, "Effect of rhBMP-2 on guided bone regeneration in humans", Clin Oral Implants Res, 14, pp.556~568 (2003)
- Dohzono S, "Successful spinal fusion by E. coli-derived BMP-2-adsorbed porous beta-TCP granules: a pilot study", Clin Orthop Relat Res, 467, pp.3206~3212 (2009)
- Han DK, "Effect of a brin-bronectin sealing system as a carrier for recombinant human bone morphogenetic protein-4 on bone formation in rat calvarial defects", J Periodontol, 76, pp.2216~2222 (2005)
- Boden SD, "Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2", hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate, 1999, pp.24, 1179~1185
- Urist MR, "Bone morphogenesis in implants of insoluble bone gelatin", Proc Natl Acad Sci U S A, 70, pp.3511~3515 (1973)
- Aizawa M, "Transplanted bone and transplantation immunity", Proc Japan Soc Path, 62, pp.69~98 (1973)
- Benglis D, "A comprehensive review of the safety prole of bone morphogenetic protein in spine surgery", Neurosurgery, 62(5 Suppl 2), pp.ONS423~ONS431 (2008)
- Cochran DL, "Evalua tion of recombinant human bone morphogenetic protein-2 in oral applications including the use of endosseous implants: 3-year results of a pilot study in humans", J Periodontol, 71, pp.1241~1257 (2000)
- Cicciù M, "Recombinant human bone morphogenetic protein type 2 application for a possible treatment of bisphosphonates-related osteonecrosis of the jaw", J Craniofac Surg, 23, pp.784~788 (2012)
- Boyne PJ, "De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation", J Oral Maxillofac Surg, 63, pp.1693~1707 (2005)
