과산화수소가 배합된 제제의 치아미백효과에 관한 연구
Tooth whitening effect of toothpaste containing hydrogen peroxide
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Objectives : The purpose of this study was to evaluate the tooth whitening effect of 0.74%and 2.80% hydrogen peroxide toothpastes and safety on tooth and gingival tissue. Methods : Toothpastes containing 0.74% and 2.80% hydrogen peroxide were evaluated. Inin-vitro test, some additives (sodium metaphosphate, sodium pyrophosphate and titanium dioxide)were added to the toothpastes. Hydroxyapatite specimens (HAPs) were made and stained usingmodified Stookey’s methods. HAPs were treated for 1 hour at shaking incubator and brushedfor 1,000 times as 250 gF with each diluted toothpaste. Before and after color was measuredby colorimeter. Using double blind method, 99 Korean with natural maxillary anterior teeth wereselected and the initial brightness (baseline) was measured by SHADEEYE-EX. Based on thismeasurement they were crossly distributed into control group (0% hydrogen peroxide), test 1(0.74% hydrogen peroxide) and test 2 (2.80% hydrogen peroxide). After 2 weeks, people ofeach group were provided toothpaste and told to use 3 times a day right after every meal for3 minutes. The brightness of teeth was measured 3 times for every one month. Results : ΔL was statistically significant among three groups in shaking test. ΔL of two testgroups was statistically significant compared with control group but not between each test groupin brushing test. After using toothpaste for 3 months, test 1 group and test 2 group were 15.89%and 31.23% more whitened compared with control group respectively (p<0.05). Rate of morewhitened person of each test group was 24.2% and 40.5% more than control group respectively(p<0.05). There was no difference in the hypersensitivity during 3 months using toothpastes andno side effect on teeth or gums. Conclusions : Toothpastes containing 0.74% and 2.80% hydrogen peroxide showed toothwhitening effect and both were safe enough to use for tooth whitening.
Abstract
Objectives : The purpose of this study was to evaluate the tooth whitening effect of 0.74%and 2.80% hydrogen peroxide toothpastes and safety on tooth and gingival tissue. Methods : Toothpastes containing 0.74% and 2.80% hydrogen peroxide were evaluated. Inin-vitro test, some additives (sodium metaphosphate, sodium pyrophosphate and titanium dioxide)were added to the toothpastes. Hydroxyapatite specimens (HAPs) were made and stained usingmodified Stookey’s methods. HAPs were treated for 1 hour at shaking incubator and brushedfor 1,000 times as 250 gF with each diluted toothpaste. Before and after color was measuredby colorimeter. Using double blind method, 99 Korean with natural maxillary anterior teeth wereselected and the initial brightness (baseline) was measured by SHADEEYE-EX. Based on thismeasurement they were crossly distributed into control group (0% hydrogen peroxide), test 1(0.74% hydrogen peroxide) and test 2 (2.80% hydrogen peroxide). After 2 weeks, people ofeach group were provided toothpaste and told to use 3 times a day right after every meal for3 minutes. The brightness of teeth was measured 3 times for every one month. Results : ΔL was statistically significant among three groups in shaking test. ΔL of two testgroups was statistically significant compared with control group but not between each test groupin brushing test. After using toothpaste for 3 months, test 1 group and test 2 group were 15.89%and 31.23% more whitened compared with control group respectively (p<0.05). Rate of morewhitened person of each test group was 24.2% and 40.5% more than control group respectively(p<0.05). There was no difference in the hypersensitivity during 3 months using toothpastes andno side effect on teeth or gums. Conclusions : Toothpastes containing 0.74% and 2.80% hydrogen peroxide showed toothwhitening effect and both were safe enough to use for tooth whitening.
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