비타민 K의 골 건강 증진 효과
Beneficial effect of vitamin K on bone health
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Originally, vitamin K was defined as a factor for blood coagulation. Now more attention is focused on vitamin K for bone metabolism and bone health. Vitamin K is a coenzyme for glutamate carboxylase which converts glutamate residues to γ-carboxyglutamate(Gla) residues. Gla residues have calcium binding ability and bound to hydroxyapatite crystals in bone. Vitamin K promotes the carboxylation of osteocalcin and matrix Gla-protein,vitamin K-dependent proteins and improves bone mineral density and bone mass. Vitamin K deficiency causes reductions in bone mineral density and increases the risk of osteoporotic bone fractures, resulting from undercarboxylated osteocalcin. This paper is to provide a brief information of vitamin K and its role in bone health.
Abstract
Originally, vitamin K was defined as a factor for blood coagulation. Now more attention is focused on vitamin K for bone metabolism and bone health. Vitamin K is a coenzyme for glutamate carboxylase which converts glutamate residues to γ-carboxyglutamate(Gla) residues. Gla residues have calcium binding ability and bound to hydroxyapatite crystals in bone. Vitamin K promotes the carboxylation of osteocalcin and matrix Gla-protein,vitamin K-dependent proteins and improves bone mineral density and bone mass. Vitamin K deficiency causes reductions in bone mineral density and increases the risk of osteoporotic bone fractures, resulting from undercarboxylated osteocalcin. This paper is to provide a brief information of vitamin K and its role in bone health.
참고문헌 (46)
- 민병무, "구강생화학", pp.77~83 (2007), 대한나래출판사
- Pejcˇic´ A, "Pediodontitis and osteoporosis", Med Biol, 12, pp.100~103 (2005)
- 2009 국민건강통계: 국민 건강영양조사 제4기 3차년도, "보건복지부 질병관리본부", 보건복지 부, 56~64 (2010)
- 강병문, "골다골증 치료의 의학약제와 대체 약물의 비교", Obstetrics & Gynecology Science, 49(12), pp.2459~2472 (2006), 대한산부인과학회
- Marx RE, "Pamidronate(Aredia) and zolendronate( Zometa) induced avascular necrosis of the jaws: a growing epidemic", J Oral Maxillofac Surg, 61, pp.1115~1117 (2003)
- 박용덕, "한국인 치과의사의 비스포스포네이트 관련 악골괴사에 대한 인식 연구 : 예비보고", 대한구강악안면외과학회지, 35(3), pp.153~157 (2009), 대한구강악안면외과학회
- Kaczor T, "Vitamin K and osteoporosis", Natural Med J, 1, pp.1~12 (2009)
- Adam J, "Vitamin K in the treatment and prevention of osteoporosis and arterial calcification", Am J Health-Syst Pharm, 62, pp.1574~1581 (2005)
- Kamao M, "Vitamin K Content of Foods and Dietary Vitamin K Intake in Japanese young women", J Nutr Sci Vitaminol, 53, pp.464~470 (2007)
- Damon M, "Phylloquinone(vitamin K1) content of vegetables", J Food Com Anal, 18, pp.751~758 (2005)
- 박광균, "치과영양학. 2판", pp.130~132 (2007), 대한나래출판사
- Lamson, DW, "The anticancer effects of vitamin K", Alternative Med Rev, 8, pp.303~318 (2003)
- Suttie JW, "Vitamin K and human nutrition", J Am Diet Assos, 92, pp.585~590 (1992)
- Büel S, "Vitamin K and bone health", Proc Nutr Soc, 62, pp.839~843 (2003)
- Uotila L, "The metabolic functions and mechanism of action of vitamin K", Scand J Clin Lab Invest Suppl, 201, pp.109~117 (1990)
- Vermeer C, "Role of vitamin K in bone metabolism", Ann Rev Nutr, 15, pp.1~22 (1995)
- Shearer MJ, "Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification", Curr Opin Clin Nutr Metab Care, 3, pp.433~438 (2000)
- Price PA, "Characterization of a gamma-carboxyglutamic acid containing protein from bone", Proc Nat Acad Sci USA, 73, pp.1447~1451 (1976)
- Hauschka PV, "Osteocalcin and matrix Gla protein: Vitamin K-dependent proteins in bone", Physiol Rev, 69, pp.990~1047 (1989)
- Weber P, "Vitamin K and Bone Health", Nutr, 17, pp.880~887 (2001)
- Hara K, "The inhibitory effect of vitamin K2(menatetrenone) on bone resorption may be related to its side chain", Bone, 16, pp.179~184 (1995)
- Schurgers LJ, "Vitamin K2 improves bone strength in postmenopausal women", Int Congr Ser, 1297, pp.179~187 (2007)
- Zittermann A, "Effects of vitamin K on calcium and bone metabolism", Curr Opin Clin Nutr Metab Care, 4, pp.483~487 (2001)
- Kohlmeier H, "Transport of vitamin K to bone in humans", J Nutr, 126, pp.1192S~1196S (1996)
- Compston JE, "Boning up on vitamin K", Gut, 48, pp.448~449 (2001)
- Szulc P, "Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women", J Clin Invest, 91, pp.1769~1774 (1993)
- van Summeren M, "Pronounced elevation of undercarboxylated osteocalcin in healthy children", Pediatr Res, 61, pp.366~370 (2007)
- Szulc P, "Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women", J Clin Invest, 91, pp.1769~1774 (1993)
- Feskanish D, "intake and hip fractures in women: a prospective study", Am J Clin Nutr, 69, pp.74~79 (1999)
- Jie KS, "Vitamin K status and bone mass in women with and without aortic atherosclerosis: a populationbased study", Calcif Tissue Int, 59, pp.352~356 (1996)
- Szulc P, "Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year followup study", Bone, 18, pp.487~488 (1996)
- Booth SL, "Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women", Am J Clin Nutr, 71, pp.1201~1208 (2000)
- Douglas AS, "Carboxylation of osteocalcin in postmenopausal osteoporotic women following vitamin K and D supplementation", Bone, 17, pp.15~20 (1995)
- Binkley NC, "Vitamin K supplementation reduces serum concentrations of undergamma-carboxylated osteocalcin in healthy young and elderly adults", Am J Clin Nutr, 72, pp.1523~1528 (2000)
- Iwamoto J, "Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis", J Orthop Sci, 5, pp.546~551 (2000)
- Takahashi M, "Effect of vitamin K and", or D on undercarboxylated and intact osteocalcin in osteoporotic patients with vertebral or hip fractures, 2001, pp.54, 219~224
- Hidaka T, "Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K2", J Bone Miner Metab, 20, pp.235~239 (2002)
- Shiraki M, "Vitamin K2(menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis", J Bone Miner Res, 15, pp.515~521 (2000)
- Miki T, "Vitamin K2(menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis", J Bone Miner Metab, 21, pp.161~165 (2003)
- Tani Y, "Menaquinone(vitamin K2)-6 production by mutants of Flavobacterium meningosepticum", J Nutr Sci Vitaminol, 32, pp.137~145 (1986)
- Sato T, "Production of menaquinone(vitamin K2)-7 by Bacillus subtilis", J Biosci Bioeng, 91, pp.16~20 (2001)
- Sato T, "Efficient production of menaquinone(vitamin K2) by a menadione- resistant mutant of Bacillus subtilis", J Ind Microbiol Biotechnol, 26, pp.115~120 (2001)
- Sumi H, "Increasing the production of nattokinase and vitamin K2 in natto with dipicolinic acid", Open Food Sci J, 3, pp.10~14 (2009)
- Tsukamoto Y, "Construction of a Bacillus subtilis(Natto) with high productivity of vitamin K2(menaquinone-7) by analog resistance", Biosci Biotechnol Biochem, 65, pp.2007~2015 (2001)
- Morishita T, "Production of manaquinones by lactic acid bacteria", J Dairy Sci, 82, pp.1897~1903 (1999)
- Hojo K, "Quantitative measurement of tetrahydromenaquinone- 9 in cheese fermented by propionibacteria", J Dairy Sci, 90, pp.4078~4083 (2007)
