제2형 당뇨병 환자에서 자가 인식한 치은 출혈 및 구취와 당화혈색소 간의 연관성
Association between self-assessed gingival bleeding and halitosis, and glycated hemoglobin levels in patients with diabetes
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Objectives: This study aimed to analyze the association between self-assessed periodontal symptoms and glycated hemoglobin levels in patients with type 2 diabetes. Methods: This cross-sectional study involved 156 patients with type 2 diabetes who were aged 50 years or older. Structured questionnaires were used to investigate the self-assessed periodontal symptoms of the patients. The glycated hemoglobin test was performed to evaluate their long-term blood glycemic control. Chi-square test and logistic multiple regression were performed to analyze the factors associated with glycated hemoglobin levels. Results: Compared with patients aged 65 years and above, more patients aged 64 years and below showed poor glycemic control (p=0.020). Further, compared with patients without self-perceived gingival bleeding and halitosis, more patients with these two conditions showed poor glycemic control (p<0.05). Compared with the group of patients without any periodontal symptoms, the group of patients that had at least one periodontal symptom had a higher proportion of patients with poor glycemic control (p<0.001). In the logistic regression model, gingival bleeding and halitosis were the factors most associated with hyperglycemia (p<0.05). Conclusions: The results of our study suggest that gingival bleeding and halitosis can predict hyperglycemia in patients with type 2 diabetes.
Abstract
Objectives: This study aimed to analyze the association between self-assessed periodontal symptoms and glycated hemoglobin levels in patients with type 2 diabetes. Methods: This cross-sectional study involved 156 patients with type 2 diabetes who were aged 50 years or older. Structured questionnaires were used to investigate the self-assessed periodontal symptoms of the patients. The glycated hemoglobin test was performed to evaluate their long-term blood glycemic control. Chi-square test and logistic multiple regression were performed to analyze the factors associated with glycated hemoglobin levels. Results: Compared with patients aged 65 years and above, more patients aged 64 years and below showed poor glycemic control (p=0.020). Further, compared with patients without self-perceived gingival bleeding and halitosis, more patients with these two conditions showed poor glycemic control (p<0.05). Compared with the group of patients without any periodontal symptoms, the group of patients that had at least one periodontal symptom had a higher proportion of patients with poor glycemic control (p<0.001). In the logistic regression model, gingival bleeding and halitosis were the factors most associated with hyperglycemia (p<0.05). Conclusions: The results of our study suggest that gingival bleeding and halitosis can predict hyperglycemia in patients with type 2 diabetes.
참고문헌 (30)
- Karakaya J, "The performance of hemoglobin A1c against fasting plasma glucose and oral glucose tolerance test in detecting prediabetes and diabetes", J Res Med Sci, 19(11), pp.1051~1057 (2014)
- Chung JKO, "Accuracy of fasting plasma glucose and hemoglobin A1c testing for the early detection of diabetes : a pilot study", Frontiers in Laboratory Medicine, 1(2), pp.76~81 (2017)[DOI]
- Korea Health Statistics 2016: Korea National Health and Nutrition Examination Survey(KNHANES Ⅶ-1), "Ministry of Health & Welfare", Ministry of Health & Welfare, 52~53 (2017)
- Alam U, "General aspects of diabetes mellitus", Handb Clin Neurol, 126, pp.211~222 (2014)[DOI]
- Shoelson SE, "Inflammation and insulin resistance", J Clin Invest, 116(7), pp.1793~1801 (2006)
- Costa KL, "Influence of periodontal disease on changes of glycated hemoglobin levels in patients with type 2 diabetes mellitus : a retrospective cohort study", J Periodontol, 88(1), pp.17~25 (2017)
- Albert DA, "Diabetes and oral disease : implications for health professionals", Ann N Y Acad Sci, 1255, pp.1~15 (2012)[DOI]
- Garton BJ, "Root caries and diabetes : risk assessing to improve oral and systemic health outcomes", Aust Dent J, 57(2), pp.114~122 (2012)[DOI]
- Kogawa EM, "Impact of glycemic control on oral health status in type 2 diabetes individuals and its association with salivary and plasma levels of chromogranin A", Arch Oral Biol, 62, pp.10~19 (2016)[DOI]
- Weinspach K, "Level of information about the relationship between diabetes mellitus and periodontitis—results from a nationwide diabetes information program", Eur J Med Res, 18, pp.6~ (2013)[DOI]
- Newsholme P, "Nutrient regulation of insulin secretion and action(2014)", J Endocrinol, 221(3), pp.R105~R120 (2014)[DOI]
- 윤우준, "공복혈당과 당화혈색소에 의한 당뇨병 진단 비교", 예방의학회지, 43(5), pp.451~454 (2010), 대한예방의학회
- Kocher T, "Periodontal complications of hyperglycemia", diabetes mellitus : epidemiologic complexity and clinical challenge, 2018, pp.78(1), 59~97
- Gil-Montoya JA, "Oral health in the elderly patient and its impact on general well-being : a nonsystematic review", Clin Interv Aging, 11, pp.461~467 (2015)[DOI]
- Nadanovsky P, "Prevalence of self-reported gingival bleeding in a representative sample of the Brazilian adolescent population", J Clin Periodontol, 45(8), pp.952~958 (2018)[DOI]
- Gilbert GH, "Multidimensionality of oral health in dentate adults", Med Care, 36(7), pp.988~1001 (1998)
- Dumitrescu AL, "Self-reported oral health status, oral health-related behaviours, resilience and hope in Romania", Oral Health Prev Dent, 7(3), pp.251~259 (2009)
- Gilbert GH, "The paradox of dental need in a population-based study of dentate adults", Med Care, 41(1), pp.119~134 (2003)
- Faul F, "Statistical power analyses using G*power 3.1:tests for correlation and regression analyses", Behav Res Methods, 41(4), pp.1149~1160 (2009)[DOI]
- Tsai C, "Glycemic control of type 2 diabetes and severe periodontal disease in the US adult population", Community Dent Oral Epidemiol, 30(3), pp.182~192 (2002)
- Ng SK, "Oral health-related quality of life and periodontal status", Community Dent Oral Epidemiol, 34(2), pp.114~122 (2006)
- Buset SL, "Are periodontal diseases really silent? A systematic review of their effect on quality of life", J Clin Periodontol, 43(4), pp.333~344 (2016)[DOI]
- Roy M, "Periodontal health in a cohort of subjects with type 1 diabetes mellitus", Clin Exp Dent Res, 5(3), pp.243~249 (2019)[DOI]
- Leite RS, "Oral health and type 2 diabetes", Am J Med Sci, 345(4), pp.271~273 (2013)[DOI]
- Lalla E, "Diabetes mellitus and periodontitis : a tale of two common interrelated diseases", Nat Rev Endocrinol, 7(12), pp.738~748 (2011)[DOI]
- Lakschevitz F, "Diabetes and periodontal diseases: interplay and links", Curr Diabetes Rev, 7(6), pp.433~439 (2011)
- Bascones-Martínez A, "Diabetes and periodontal disease : review of the literature", Am J Dent, 27(2), pp.63~67 (2014)
- Wang S, "Glycemic control and adipokines after periodontal therapy in patients with Type 2 diabetes and chronic periodontitis", Braz Oral Res, 31, pp.e90~ (2017)[DOI]
- Verhulst MJ, "Self-reported oral health and quality of life in patients with type 2 diabetes mellitus in primary care : a multi-center crosssectional study", Diabetes Metab Syndr Obes, 12, pp.883~899 (2019)[DOI]
- Birch S, "Patient preferences and the measurement of utilities in the evaluation of dental technologies", J Dent Res, 81(7), pp.446~450 (2002)[DOI]