본문 바로가기
KERD
논문KCI 등재

보조적 프로바이오틱스 복용을 통한 치주 병원성 세균 및 전신질환 지표 변화: 증례보고

Changes in periodontal pathogens and chronic disease indicators through adjunctive probiotic supplementation : a case report

1

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류치의학

초록

Objectives: This case study aimed to evaluate changes in periodontal pathogens and systemic disease indicators following the adjunctive use of probiotics for periodontal treatment. Methods: Two adults, a 64-year-old male and 71-year-old female, were selected with ethical approval and underwent comprehensive oral and systemic health assessments before and after probiotic intake with periodontal debridement. Results: There was a significant reduction in the periodontal pathogens, particularly Porphyromonas gingivalis and Treponema forsythia, and no adverse systemic indicators were observed. Moreover, a trend toward improved lipid profiles was noted, suggesting a potential positive impact on systemic health. Conclusions: This study shows the potential role of probiotics in enhancing oral health and preventing systemic diseases, thus highlighting the need for further research and clinical trials.

Abstract

Objectives: This case study aimed to evaluate changes in periodontal pathogens and systemic disease indicators following the adjunctive use of probiotics for periodontal treatment. Methods: Two adults, a 64-year-old male and 71-year-old female, were selected with ethical approval and underwent comprehensive oral and systemic health assessments before and after probiotic intake with periodontal debridement. Results: There was a significant reduction in the periodontal pathogens, particularly Porphyromonas gingivalis and Treponema forsythia, and no adverse systemic indicators were observed. Moreover, a trend toward improved lipid profiles was noted, suggesting a potential positive impact on systemic health. Conclusions: This study shows the potential role of probiotics in enhancing oral health and preventing systemic diseases, thus highlighting the need for further research and clinical trials.

참고문헌 (30)

  1. Pihlstrom BL, "Periodontal diseases", Lancet, 366(9499), pp.1809~1820 (2005)[DOI]
  2. Han YW, "Mobile microbiome : oral bacteria in extra-oral infections and inflammation", J Dent Res, 92(6), pp.485~491 (2013)[DOI]
  3. Ford PJ, "Inflammation, heat shock proteins and periodontal pathogens in atherosclerosis : an immunohistologic study", Oral Microbiol Immunol, 21(4), pp.206~211 (2006)[DOI]
  4. Gonzales-Marin C, "Maternal oral origin of Fusobacterium nucleatum in adverse pregnancy outcomes as determined using the 16S-23S rRNA gene intergenic transcribed spacer region", J Med Microbiol, 62(Pt 1), pp.133~144 (2013)[DOI]
  5. Martinez-Martinez RE, "Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients", J Clin Periodontol, 36(12), pp.1004~1010 (2009)[DOI]
  6. Cobb CM, "Non-surgical pocket therapy : mechanical", Ann Periodontol, 1(1), pp.443~490 (1996)[DOI]
  7. Heitz-Mayfield LJ, "Systemic antibiotics in periodontal therapy", Aust Dent J, 54(S1), pp.S96~S101 (2009)[DOI]
  8. Teughels W, "Adjunctive effect of systemic antimicrobials in periodontitis therapy : a systematic review and meta-analysis", J Clin Periodontol, 47(S22), pp.257~281 (2020)[DOI]
  9. Gillam DG, "Antibiotics in the treatment of periodontal disease : a guide for the general dental practitioner", Prim Dent J, 3(3), pp.43~47 (2014)[DOI]
  10. Sanders ME, "An update on the use and investigation of probiotics in health and disease", Gut, 62(5), pp.787~796 (2013)[DOI]
  11. Stamatova I, "Probiotics and periodontal disease", Periodontol 2000, 51(1), pp.141~151 (2009)[DOI]
  12. Allaker RP, "Use of Probiotics and Oral Health", Curr Oral Health Rep, 4(4), pp.309~318 (2017)[DOI]
  13. Martin-Cabezas R, "Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis : a systematic review and meta-analysis", J Clin Periodontol, 43(6), pp.520~530 (2016)[DOI]
  14. Choi Y, "Improvement of periodontal disease by novel probiotics Lactobacillus curvatus SMFM2016-NK", Doctor, pp.2020
  15. Fleiss JL, "Representativeness of the"Ramfjord teeth"for epidemiologic studies of gingivitis and periodontitis", Community Dent Oral Epidemiol, 15(4), pp.221~224 (1987)[DOI]
  16. Laitinen K, "Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy : a randomised controlled trial", Br J Nutr, 101(11), pp.1679~1687 (2009)[DOI]
  17. Hoppu U, "Maternal dietary counseling reduces total and LDL cholesterol postpartum", Nutrition, 30(2), pp.159~164 (2014)[DOI]
  18. Canut-Delgado N, "Are probiotics a possible treatment of periodontitis? probiotics against periodontal disease : a systematic review", Br Dent J, pp.1~7 (2021)[DOI]
  19. von Troil-Lindén B, "Salivary levels of suspected periodontal pathogens in relation to periodontal status and treatment", J Dent Res, 74(11), pp.1789~1795 (1995)[DOI]
  20. Invernici MM, "Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis : a randomized clinical trial", J Clin Periodontol, 45(10), pp.1198~1210 (2018)[DOI]
  21. Vivekananda MR, "Effect of the probiotic Lactobacilli reuteri(Prodentis)in the management of periodontal disease : a preliminary randomized clinical trial", J Oral Microbiol, 2(1), pp.5344~ (2010)[DOI]
  22. Park DY, "Antimicrobial activity of Limosilactobacillus fermentum strains isolated from the human oral cavity against Streptococcus mutans", Sci Rep, 13(1), pp.7969~ (2023)[DOI]
  23. Fiorillo L, "Porphyromonas gingivalis, periodontal and systemic implications : a systematic review", Dent J(Basel), 7(4), pp.114~ (2019)[DOI]
  24. Fan Z, "Fusobacterium nucleatum and its associated systemic diseases : epidemiologic studies and possible mechanisms", J Oral Microbiol, 15(1), pp.2145729~ (2023)[DOI]
  25. Sharma S, "Potential of probiotics in hypercholesterolemia : a meta-analysis", Indian J Public Health, 60(4), pp.280~286 (2016)[DOI]
  26. Wu Y, "Effect of probiotic Lactobacillus on lipid profile : a systematic review and meta-analysis of randomized, controlled trials", PLoS One, 12(6), pp.e0178868~ (2017)[DOI]
  27. Park DY, "Complete genome sequence of hydrogen peroxide-producing Limosilactobacillus fermentum DM072 isolated from the human oral cavity", Microbiol Resour Announc, 11(12), pp.e0089722~ (2022)[DOI]
  28. Park DY, "Complete genome sequence of Lactiplantibacillus plantarum strain DM083 isolated from human tongue coating", Microbiol Resour Announc, 11(10), pp.e0067522~ (2022)[DOI]
  29. Park DY, "Whole-genome sequence of Limosilactobacillus fermentum strain DM075, isolated from the human oral cavity", Microbiol Resour Announc, 11(11), pp.e0081922~ (2022)[DOI]
  30. Szkaradkiewicz AK, "Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis", Arch Immunol Ther Exp(Warsz), 62(6), pp.495~500 (2014)[DOI]

관련 논문AI추천

이 간행물의 다른 논문 (9건)