감염관리를 위한 신속 검출법을 이용한 다제내성 세균의 적극적 감염감시
Active Surveillance of Multidrug-Resistant Organisms with Rapid Detection Methods for Infection Control
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초록
여러 항균제에 대해 내성을 보이는 다제내성 세균은 한국에서 점점 심각한 문제가 되고 있고, 메티실린내성 황색 포도알균(MRSA), 반코마이신내성 장알균(VRE), 다제내성 녹농균 및 다제내성 Acinetobacter baumannii 등이 점점 증가하고 있다. 더욱이 최근에는 카바페넴 약제도 내성을 보이는 장세균군이 출현하여 전세계적으로 퍼지고 있어 보건에 긴급한 위협이 되고 있다. 무증상의 보균자에게서 다제내성 세균을 검출하는 적극적 감염감시(active surveillance)는 MRSA와 VRE의 감염 관리의 중요한 방법으로 사용되고 있으며, 다제내성 그람음성 막대균에 대해서도 효과적인 전략이 될 수 있다. 분자유적학적 방법 등을 이용한 신속한 다제내성 세균의 보균자 검출과 이를 통한 적절한 병원감염 정책은 의료관련 감염의 전파를 막을 수 있는 핵심 요소이다. [Ann Clin Microbiol 2015;18:103-110]
Abstract
Antibiotic-resistant bacteria have become an increasingly serious problem in Korea, and multidrug-resistant organisms (MDROs) such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococcus (VRE), and multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii have increased over the recent years. More seriously, the recent emergence of carbapenem resistance among Enterobacteriaceae is thought to be an urgent worldwide threat. Active surveillance have been identified as an important tool as an intensified infection control intervention for the control of MRSA and VRE and may be also an effective strategy for multidrug-resistant Gram-negative bacilli. Rapid detection using molecular methods could aid in the timely detection of MDRO carriers, and adequate application of infection control strategy could reduce the transmission of MDROs within hospital settings. (Ann Clin Microbiol 2015;18:-110)
참고문헌 (59)
- Martín-Loeches I, "Risks for multidrug-resistant pathogens in the ICU", Curr Opin Crit Care, 20, pp.516~524 (2014)
- DeLeo FR, "Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era", J Clin Invest, 119, pp.2464~2474 (2009)
- DiazGranados CA, "Impact of vancomycin resistance on mortality among patients with neutropenia and enterococcal bloodstream infection", J Infect Dis, 191, pp.588~595 (2005)
- Esterly JS, "Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections", Antimicrob Agents Chemother, 55, pp.4844~4849 (2011)
- Patel G, "Outcomes of carbapenem-resistant Klebsiella pneumoniae infection and the impact of antimicrobial and adjunctive therapies", Infect Control Hosp Epidemiol, 29, pp.1099~1106 (2008)
- "Infection Control Guidelines for Multidrug Resistant Microorganisms in Healthcare Facilities"[URL]
- Backman C, "An integrative review of infection prevention and control programs for multidrugresistant organisms in acute care hospitals : a socio-ecological perspective", Am J Infect Control, 39, pp.368~378 (2011)
- Diekema DJ, "Rapid detection of antibiotic-resistant organism carriage for infection prevention", Clin Infect Dis, 56, pp.1614~1620 (2013)
- Lee Y, "Recent trends in antimicrobial resistance in intensive care units in Korea", Korean J Nosocomial Infect Control, 19, pp.29~36 (2014)
- Xu J, "Surveillance and correlation of antimicrobial usage and resistance of Pseudomonas aeruginosa: a hospital population-based study", PLoS One, 8, pp.e78604~ (2013)
- Cho SY, "Klebsiella pneumoniae co-producing NDM-5 and OXA-181 carbapenemases, South Korea", Emerg Infect Dis, 21, pp.1088~1089 (2015)
- Sader HS, "Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals(2009-2011)", Diagn Microbiol Infect Dis, 78, pp.443~448 (2014)
- Cantón R., "Role of the microbiology laboratory in infectious disease surveillance, alert and response", Clin Microbiol Infect, 11(Suppl 1), pp.3~8 (2005)
- Muto CA, "SHEA guideline for preventing nosocomial transmission of multidrug-resistant strains of Staphylococcus aureus and Enterococcus", Infect Control Hosp Epidemiol, 24, pp.362~386 (2003)
- Tsiatsiou O, "Successful management of an outbreak due to carbapenem-resistant Acinetobacter baumannii in a neonatal intensive care unit", Eur J Pediatr, 174, pp.65~74 (2015)
- Giuffrè M, "Successful control of an outbreak of colonization by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae sequence type 258 in a neonatal intensive care unit, Italy", J Hosp Infect, 85, pp.233~236 (2013)
- Matheson A, "Nasal swab screening for methicillin-resistant Staphylococcus aureus-how well does it perform? A cross-sectional study", Infect Control Hosp Epidemiol, 33, pp.803~808 (2012)
- Warren DK, "The epidemiology of vancomycin-resistant Enterococcus colonization in a medical intensive care unit", Infect Control Hosp Epidemiol, 24, pp.257~263 (2003)
- Marlowe EM, "Conventional and molecular methods for the detection of methicillin-resistant Staphylococcus aureus", J Clin Microbiol, 49, pp.S53~S56 (2011)
- 이승옥, "Comparative Evaluation of Three Chromogenic Media Combined with Broth Enrichment and the Real-Time PCR-Based Xpert MRSA Assay for Screening of Methicillin- Resistant Staphylococcus aureus in Nasal Swabs", Annals of Laboratory Medicine, 33(4), pp.255~260 (2013), 대한진단검사의학회
- Buchan BW, "Identification of two borderline oxacillin-resistant strains of Staphylococcus aureus from routine nares swab specimens by one of three chromogenic agars evaluated for the detection of MRSA", Am J Clin Pathol, 134, pp.921~927 (2010)
- Yang HY, "Evaluation of commercial selective agars in screening for methicillin-resistant Staphylococcus aureus", Ann Clin Lab Sci, 40, pp.252~256 (2010)
- Denys GA, "Three-way comparison of BBL CHROMagar MRSA II, MRSASelect, and spectra MRSA for detection of methicillin-resistant Staphylococcus aureus isolates in nasal surveillance cultures", J Clin Microbiol, 51, pp.202~205 (2013)
- Suwantarat N, "Comparison of five chromogenic media for recovery of vancomycin-resistant enterococci from fecal samples", J Clin Microbiol, 52, pp.4039~4042 (2014)
- Ledeboer NA, "A new chromogenic agar medium, chromID VRE, to screen for vancomycin-resistant Enterococcus faecium and Enterococcus faecalis", Diagn Microbiol Infect Dis, 59, pp.477~479 (2007)
- Anderson NW, "Multicenter clinical evaluation of VRESelect agar for identification of vancomycin-resistant Enterococcus faecalis and Enterococcus faecium", J Clin Microbiol, 51, pp.2758~2760 (2013)
- Jenkins SG, "Comparison of performance of the novel chromogenic spectra VRE agar to that of bile esculin azide and Campylobacter agars for detection of vancomycin-resistant enterococci in fecal samples", J Clin Microbiol, 49, pp.3947~3949 (2011)
- Uzun B, "Comparison of cefoxitin disk diffusion test, automated system and chromogenic medium for detection of methicillin resistance in Staphylococcus aureus isolates", Mikrobiyol Bul, 47, pp.11~18 (2013)
- Dalpke AH, "Comparison of the BD Max methicillin-resistant Staphylococcus aureus(MRSA)assay and the BD GeneOhm MRSA achromopeptidase assay with directand enriched-culture techniques using clinical specimens for detection of MRSA", J Clin Microbiol, 50, pp.3365~3367 (2012)
- Patel PA, "Performance of the BD GeneOhm MRSA achromopeptidase assay for real-time PCR detection of methicillin-resistant Staphylococcus aureus in nasal specimens", J Clin Microbiol, 49, pp.2266~2268 (2011)
- Arcenas RC, "Multicenter evaluation of the LightCycler MRSA advanced test, the Xpert MRSA Assay, and MRSASelect directly plated culture with simulated workflow comparison for the detection of methicillin-resistant Staphylococcus aureus in nasal swabs", J Mol Diagn, 14, pp.367~375 (2012)
- Diederen BM, "Comparison of the Cepheid XpertTM MRSA assay with culture in a low prevalence setting in The Netherlands", J Infect, 61, pp.509~510 (2010)
- Patel PA, "Performance of the Cepheid XpertⓇ SA Nasal Complete PCR assay compared to culture for detection of methicillin-sensitive and methicillin-resistant Staphylococcus aureus colonization", Diagn Microbiol Infect Dis, 80, pp.32~34 (2014)
- 김명희, "Detection of Methicillin-Resistant Staphylococcus aureus in Healthcare Workers Using Real-Time Polymerase Chain Reaction", Yonsei Medical Journal, 54(5), pp.1282~1284 (2013), 연세대학교의과대학[DOI]
- Tacconelli E, "Rapid screening tests for meticillin-resistant Staphylococcus aureus at hospital admission : systematic review and meta-analysis", Lancet Infect Dis, 9, pp.546~554 (2009)
- Yam WC, "Evaluation of the LightCycler methicillin-resistant Staphylococcus aureus(MRSA)advanced test for detection of MRSA nasal colonization", J Clin Microbiol, 51, pp.2869~2874 (2013)
- Polisena J, "Clinical effectiveness of rapid tests for methicillin resistant Staphylococcus aureus(MRSA)in hospitalized patients : a systematic review", BMC Infect Dis, 11, pp.336~ (2011)
- Roisin S, "Impact of rapid molecular screening at hospital admission on nosocomial transmission of methicillin-resistant Staphylococcus aureus: cluster randomised trial", PLoS One, 9, pp.e96310~ (2014)
- Malhotra-Kumar S, "Current trends in rapid diagnostics for methicillin-resistant Staphylococcus aureus and glycopeptide-resistant Enterococcus species", J Clin Microbiol, 46, pp.1577~1587 (2008)
- Lee SY, "Comparison of Seeplex VRE detection kit with ChromID VRE agar for detection of vancomycin-resistant enterococci in rectal swab specimens", Ann Clin Lab Sci, 40, pp.163~166 (2010)
- 김도훈, "Evaluation of the Usefulness of Selective Chromogenic Agar Medium (ChromID VRE) and Multiplex PCR Method for the Detection of Vancomycin-resistant Enterococci", Annals of Laboratory Medicine, 30(6), pp.631~636 (2010), 대한진단검사의학회
- Werner G, "Comparison of direct cultivation on a selective solid medium, polymerase chain reaction from an enrichment broth, and the BD GeneOhmTM VanR Assay for identification of vancomycin-resistant enterococci in screening specimens", Diagn Microbiol Infect Dis, 70, pp.512~521 (2011)
- Usacheva EA, "Prospective, multicenter evaluation of the BD GeneOhm VanR assay for direct, rapid detection of vancomycin-resistant Enterococcus species in perianal and rectal specimens", Am J Clin Pathol, 134, pp.219~226 (2010)
- Gazin M, "Evaluation of GeneOhm VanR and Xpert vanA", vanB molecular assays for the rapid detection of vancomycin-resistant enterococci, 2012, pp.31, 273~276
- Sloan LM, "Comparison of the Roche LightCycler vanA", vanB detection assay and culture for detection of vancomycinresistant enterococci from perianal swabs, 2004, pp.42, 2636~2643
- Bourdon N, "Rapid detection of vancomycin-resistant enterococci from rectal swabs by the Cepheid Xpert vanA", vanB assay, 2010, pp.67, 291~293
- "Guideline of diagnostic method of CPE"[URL]
- Wilkinson KM, "Comparison of four chromogenic culture media for carbapenemase-producing Enterobacteriaceae", J Clin Microbiol, 50, pp.3102~3104 (2012)
- Dortet L, "Rapid identification of carbapenemase types in Enterobacteriaceae and Pseudomonas spp. by using a biochemical test", Antimicrob Agents Chemother, 56, pp.6437~6440 (2012)
- Dortet L, "CarbAcineto NP test for rapid detection of carbapenemase-producing Acinetobacter spp", J Clin Microbiol, 52, pp.2359~2364 (2014)
- Bush K, "Alarming β-lactamase-mediated resistance in multidrugresistant Enterobacteriaceae", Curr Opin Microbiol, 13, pp.558~564 (2010)
- Szabó D, "Outer membrane protein changes and efflux pump expression together may confer resistance to ertapenem in Enterobacter cloacae", Antimicrob Agents Chemother, 50, pp.2833~2835 (2006)
- Yang FC, "Characterization of ertapenem-resistant Enterobacter cloacae in a Taiwanese university hospital", J Clin Microbiol, 50, pp.223~226 (2012)
- Lee Y, "Molecular mechanisms of carbapenem resistance in Enterobacter cloacae clinical isolates from Korea and clinical outcome", Ann Clin Lab Sci, 42, pp.281~286 (2012)
- Naas T, "Evaluation of a DNA microarray (Check-MDR CT102) for rapid detection of TEM, SHV, and CTX-M extended-spectrum β-lactamases and of KPC, OXA-48, VIM, IMP, and NDM-1 carbapenemases", J Clin Microbiol, 49, pp.1608~1613 (2011)
- Nijhuis R, "Evaluation of a new real-time PCR assay (Check-Direct CPE) for rapid detection of KPC, OXA-48, VIM, and NDM carbapenemases using spiked rectal swabs", Diagn Microbiol Infect Dis, 77, pp.316~320 (2013)
- Tenover FC, "Detection of colonization by carbapenemase-producing Gramnegative bacilli in patients by use of the Xpert MDRO assay", J Clin Microbiol, 51, pp.3780~3787 (2013)
