Possibility and Limitation of Micro-CT in Cochlear Imaging of Rat
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The objective of this study is to investigate the degree of visualization for the macro-, micro-, and nano-structures of the cochlea with x-ray micro-CT based on a cone-beam geometry for rats. This study will provide a basic criterion to compare the visual images obtained from other techniques. Before obtaining the visual images, the hearing thresholds were obtained with auditory brainstem responses (ABR). A x-ray micro CT based on a cone-beam geometry for a small animal was used for examining the macro-, micro-, and nano-structures of the cochlea in rats. X-ray micro CT provided a clear depiction of the basal, middle, and apical cochlear turns. X-ray micro CT allows visualizing the macro-structures of the cochlea. However, it did not well depict the micro- and nano-structures of the cochlea. The present study was the first attempt to visualize the macro-structures of the cochlea with x-ray micro CT based on a cone-beam geometry for rats. To visualize the micro- and nano-structures of the cochlea, optimal parameter values of x-ray micro CT should be found and many factors such as signal-to-noise ratio, resolution, image averaging, pixel, pixel number, pixel value, exposure time, and binning should be properly considered.
Abstract
The objective of this study is to investigate the degree of visualization for the macro-, micro-, and nano-structures of the cochlea with x-ray micro-CT based on a cone-beam geometry for rats. This study will provide a basic criterion to compare the visual images obtained from other techniques. Before obtaining the visual images, the hearing thresholds were obtained with auditory brainstem responses (ABR). A x-ray micro CT based on a cone-beam geometry for a small animal was used for examining the macro-, micro-, and nano-structures of the cochlea in rats. X-ray micro CT provided a clear depiction of the basal, middle, and apical cochlear turns. X-ray micro CT allows visualizing the macro-structures of the cochlea. However, it did not well depict the micro- and nano-structures of the cochlea. The present study was the first attempt to visualize the macro-structures of the cochlea with x-ray micro CT based on a cone-beam geometry for rats. To visualize the micro- and nano-structures of the cochlea, optimal parameter values of x-ray micro CT should be found and many factors such as signal-to-noise ratio, resolution, image averaging, pixel, pixel number, pixel value, exposure time, and binning should be properly considered.
참고문헌 (17)
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