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초등학생에서 세균성 인두염 신속항원검사 SD Bioline Strep A의 평가

Evaluation of SD Bioline Strep A for Rapid Antigen Testing in Elementary Schoolchildren

김선주|고은하
대한임상미생물학회 (Korean Society of Clinical Microbiology)|2007.04|Annals of Clinical Microbiology|제10권 제1호|pp. 54-58

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초록

배경: A군 연쇄구균을 검출할 수 있는 신속항원검사는 시행하기 간편하고 , 배양 시간을 절약하는 장점이 있다 . 국내에서 개발된 신속항원검사 SD Bioline Strep A 시약을 평가하고자 본 연구를 시행하였다. 방법: 건강한 초등학생 308명으로부터 3회 인후도말을 시행하였다 . 처음 두 개 면봉은 SD Bioline Strep A와 Quidel Quick Vue Dipstick Strep A 신속항원검사를 시행하였고, 세 번째 면봉은 세균배양을 하였다. 결과: 세균배양 결과를 기준으로 SD Bioline Strep A의 예민도, 특이도, 양성예측률 및 음성예측률은 79.3%, 88.9%, 72.2% 및 92.2%였다. Quidel Quick Vue Dipstick Strep A의 예민도, 특이도, 양성예측률 및 음성예측률은 58.5%, 93.8%, 77.4% 및 86.2%였다. 결론: SD Bioline Strep A는 Quidel Quick Vue Dipstick Strep A에 비해 예민도가 유의하게 높았으며, 특이도는 약간 낮았다. 신속항원검사 SD Bioline Strep A는 세균성 인두염을 빠르게 진단하고, 적합한 항균제 치료를 하는 데 유용할 것으로판단한다.

Abstract

Background: Rapid antigen tests (RAT) of group A streptococci (GAS) are easy to perform and can save two days of bacterial culture time. Performance of SD Bioline Strep A was analyzed in comparison with throat culture. Methods: Three consecutive throat swabs were taken from 308 healthy elementary schoolchildren. The first two swabs were tested for SD Bioline Strep A and Quidel Quick Vue Dipstick Strep A rapid antigen tests, and the third one was inoculated onto blood agar plate to grow GAS. Results: Sensitivity, specificity, positive predictive value and negative predictive value of SD Bioline Strep A were 79.3%, 88.9%, 72.2%, and 92.2% respectively. Those of Quidel Quick Vue Strep A were 58.5%, 93.8%, 77.4%, and 86.2% respectively. Conclusion: SD Bioline Strep A showed a significantly higher sensitivity and a slightly lower specificity compared to Quidel Quick Vue Strep A. SD Bioline Strep A RAT should be useful for the rapid diagnosis of bacterial pharyngitis and the optimum use of antibiotics.

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관련 논문AI추천

The Evaluation of SD Bioline Strep A Rapid Antigen Test in Acute Pharyngitis in Pediatric Clinics김선주대한진단검사의학회 · Annals of Laboratory Medicine2009 · 제29권 제4호Evaluation of the SD Bioline Strep A Ultra Test in Relation With Number of Colony Forming Units and Color Intensity김선주, 마상혁, 박현웅, 최원희대한진단검사의학회 · Annals of Laboratory Medicine2019 · 제39권 제1호A군 연쇄구균 인두염의 임상양상과 두 가지 신속항원검사의 유용성 비교강은경, 김인욱, 양무열, 정혜령, 허희진대한진단검사의학회 · Laboratory Medicine Online2016 · 제6권 제2호A군 사슬알균 인두염 진단을 위한 STANDARD F Strep A Ag FIA의 성능 평가김선주, 마상혁, 이승준, 조선아대한임상미생물학회 · Annals of Clinical Microbiology2020 · 제23권 제3호소아의 급성 인두염에서 연쇄구균 신속항원검사의 유용성양승, 김미진, 김영호, 이혜란, 임기현, 정지아, 최우진, 황일태대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2006 · 제16권 제1호A군 연쇄구균 상기도 감염에 있어 신속검사의 유용성김연호, 마상혁, 배영민, 차성호대한소아감염학회 · Pediatric Infection and Vaccine2001 · 제8권 제1호

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