랫드에서 아니사키스 유충에 대한 이버멕틴과 도라멕틴의 운동성 억제효과
Effect of ivermectin and doramectin for larval(Anisakis spp) migratory inhibition in rats
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This experiment has been investigated in order to examine the effect of ivermectin and doramectin for laval migratory inhibition in rats. Anisakis spp larvae were obtained from the mackerels in fish market in Cheongju. A total of 225 rats were classified with 3 groups with the same number(3×75 rats); group I was control divided into 3 subgroups including 25 rats in each one, others(test groups) were treated subcutaneously with ivermectin and doramectin by 3 kinds of concentrations (200㎍/㎏, 400, 800), respectively. At 15 minutes after treating, 10 larvae were taken orally into each rat of 6 subgroups in test, and 5 rats were necropsied at 0.5, 1, 2, 4 and 8 hours after oral administration. The recovered larvae were used in larval migration inhibition(LMI). Ivermectin is significantly more effective than doramectin. In rats, the inhibitory effect of ivermectin and doramectin is slightly less than in vitro.
Abstract
This experiment has been investigated in order to examine the effect of ivermectin and doramectin for laval migratory inhibition in rats. Anisakis spp larvae were obtained from the mackerels in fish market in Cheongju. A total of 225 rats were classified with 3 groups with the same number(3×75 rats); group I was control divided into 3 subgroups including 25 rats in each one, others(test groups) were treated subcutaneously with ivermectin and doramectin by 3 kinds of concentrations (200㎍/㎏, 400, 800), respectively. At 15 minutes after treating, 10 larvae were taken orally into each rat of 6 subgroups in test, and 5 rats were necropsied at 0.5, 1, 2, 4 and 8 hours after oral administration. The recovered larvae were used in larval migration inhibition(LMI). Ivermectin is significantly more effective than doramectin. In rats, the inhibitory effect of ivermectin and doramectin is slightly less than in vitro.
참고문헌 (20)
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