SPF 닭에서 레오바이러스와 아데노바이러스의 단일 혹은 혼합감염에 따른 병원성 비교
The comparison of pathogenicity in the SPF chickens challenged with avian reovirus and/or fowl adenovirus
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Avian reovirus (ARV) and fowl adenovirus (FAdV) were evaluated for pathogenicity in specific pathogen free (SPF) chickens. ARV was isolated from the broilers with history of malabsorption syndrome (MAS). FAdV was isolated from the layer breeders with inclusion body hepatitis and hydropericardium syndrome. Total 6 inoculated groups including 1 un-inoculated group were organized and inoculated with the ARV and/or FAdV by oral route. The minimal pathological lesions and lower viral gene detection rates were present in the ARV inoculated groups compared to those of FAdV or ARV/FAdV inoculated groups. Common gross lesions in the ARV inoculated group were distended intestine with foamy contents and in the FAdV group there were foamy cecal contents and hydropericardium among the evaluation methods such as gross and histological lesion, viral gene detection,body weight and serum chemistry, histopathological lesion score was reliable especially in the liver lesions such as hepatic necrosis and lymphocytic infiltration. However, we did not success to evaluate the synergetic effect of mixed infection of ARV and FAdV in this study. Therefore, we need further study to reproduce malabsorption syndrome of ARV infection using different viral agent such as rotavirus and using different dose of virus.
Abstract
Avian reovirus (ARV) and fowl adenovirus (FAdV) were evaluated for pathogenicity in specific pathogen free (SPF) chickens. ARV was isolated from the broilers with history of malabsorption syndrome (MAS). FAdV was isolated from the layer breeders with inclusion body hepatitis and hydropericardium syndrome. Total 6 inoculated groups including 1 un-inoculated group were organized and inoculated with the ARV and/or FAdV by oral route. The minimal pathological lesions and lower viral gene detection rates were present in the ARV inoculated groups compared to those of FAdV or ARV/FAdV inoculated groups. Common gross lesions in the ARV inoculated group were distended intestine with foamy contents and in the FAdV group there were foamy cecal contents and hydropericardium among the evaluation methods such as gross and histological lesion, viral gene detection,body weight and serum chemistry, histopathological lesion score was reliable especially in the liver lesions such as hepatic necrosis and lymphocytic infiltration. However, we did not success to evaluate the synergetic effect of mixed infection of ARV and FAdV in this study. Therefore, we need further study to reproduce malabsorption syndrome of ARV infection using different viral agent such as rotavirus and using different dose of virus.
참고문헌 (37)
- Abdul-Aziz TA, "New syndrome in Iraqi chicks", Vet Rec, 129(12), pp.272~ (1991)
- Abe T, "Histiology, immunohistochemistry, and ultrastructure of hydropericardium syndrome in adult broiler breeders and broiler chicks", Avian Dis, 42(3), pp.606~612 (1998)
- Ahmad I, "Disease pattern and etiology of hydropericardium syndrome (Angara disease) in broiler chickens in Pakistan", Pak J Agric Res, 10(2), pp.195~199 (1989)
- Decaesstecker M, "Significance of paroviruses, entero-like viruses and reoviruses in the aetiology of the chicken malabsorption syndrome", Avian Pathol, 15(4), pp.769~782 (1986)
- Decaesstecker M, "Epidemiological study of enteric viruses in broiler chickens: Comparison of tissue culture and direct electron microscopy", Avian Pathol, 17(2), pp.477~486 (1988)
- Dobson KN, "Economic impact of a documented case of reovirus infection in broiler breeders", Avian Dis, 36(3), pp.788~791 (1992)
- Goodwin MA, "Enteritis (so-called runting stunting syndrome) in Georgia broiler chicks", Avian Dis, 37(2), pp.451~458 (1993)
- Gouvea V, "Pathogenicity of avian reoviruses: examination of six isolates and a vaccine strain", Infect Immun, 38(2), pp.731~738 (1982)
- Hess M, "Epidemiological studies on fowl adenoviruses isolated from cases of infectious hydropericardium", Avian Pathol, 28(5), pp.433~439 (1999)
- Jones RC, "Reoviruses from chickens with hydropericardium", Vet Rec, 99(23), pp.458~ (1975)
- Khawaraja DA, "Isolation of an adenovirus from hydropericardium syndrome in broiler chicks", Pak J Vet Res, 1, pp.2~17 (1988)
- 모인필, "Outbreaks of Hydropericardium Syndrome and Molecular Characterization of Korean Fowl Adenoviral Isolates", AVIAN DISEASES, 52(3), pp.526~530, AMER ASSOC AVIAN PATHOLOGISTS
- Kouwenhoven B, "Investigations into the role of reovirus in the malabsorption syndrome", Avian Pathol, 17(4), pp.879~892 (1988)
- Lenz SD, "Gastrointestinal pathogenicity of adenoviruses and reoviruses isolated from broiler chickens in Alabama", J VeT Diagn Invest, 10(2), pp.145~151 (1998)
- Mandelli G, "Experimental reovirus hepatitis in new born chicks", Vet Pathol, 15, pp.531~543 (1978)
- Mazaheri A, "Some strains of serotype 4 fowl adenoviruses cause inclusion body hep atitis and hydropericardium syndrome in chickens", Avian Pathol, 27(3), pp.269~276 (1998)
- McFerran JB, "Isolation of viruses from clinical outbreaks of inclusion body hepatitis", Avian Pathol, 5(4), pp.315~324 (1976)
- McNeilly F, "Synergism between chicken anemia virus (CAV) and avian reovirus following dual infection of 1-day-old chicks by a natural route", Avian Dis, 39(3), pp.532~537 (1995)
- McNulty MS, "An entero-like virus associated with the runting syndrome in broiler chickens", Avian Pathol, 13(3), pp.429~439 (1984)
- Montgomery RD, "Attempts to reproduce a runting", stunting-type syndrome using infectious agents isolated from affected Mississippi broilers, 1997, pp.41(1), 80~92
- Montgomery RD, "Role of route of exposure, age, sex, and type of chicken on the pathogenicity of avian reovirus strain 81-176", Avian Dis, 30(3), pp.460~467 (1986)
- Nakamura K, "Pathology study of specific-pathogen-free chicks and hens inoculated with adenovirus isolated from hydropericardium syndrome", Avian Dis, 43(3), pp.414~423 (1999)
- Ni Y, "A comparative study of avian reovirus pathogenicity: virus spread and replication and induction of lesion", Avian Dis, 39(3), pp.554~566 (1995)
- Rekik MR, "Serological and pathogenic characterization of avian reoviruses isolated in Quebec", Avian Pathol, 20(4), pp.607~617 (1991)
- Shirai J, "Experimental infection in specific-pathogen-free chicks with avian reovirus and avian nephritis showing runting syndrome", Avian Dis, 34(2), pp.295~303 (1990)
- Simmons DG, "Isolation,identification,and characterization of an avian respiratory reovirus", Bull Ga Acad Sci, 30, pp.1~10 (1972)
- Smart IJ, "Experimental reproduction of the runting-stunting syndrome of broiler chickens", Avian Pathol, 17(3), pp.617~627 (1988)
- Songserm T, "A comparative study of the pathogenesis of malabsorption syndrome in broilers", Avian Dis, 44(3), pp.556~567 (2000)
- Songserm T, "Enteropathogenicity of Dutch and German avian reoviruses in SPF white leghorn and chickens and broilers", Vet Res, 34(3), pp.285~295 (2003)
- Songserm T, "Experimental reproduction of malabsorption syndrome with different combination of reovirus, Escherichia coli, and treated homogenates obtained from broilers", Avian Dis, 46(1), pp.87~94 (2002)
- Spandidos DA, "Physical and chemical characterization of an avian reovirus", J Virol, 19(3), pp.968~976 (1976)
- Swati D, "Fowl adenovirus serotype 4 associated with outbreaks of infectious hydropericardium in Haryana, India", Avian Dis, 46(1), pp.230~233 (2002)
- Tang KN, "Comparative study of the pathogenicity of avian reoviruses", Avian Dis, 31(3), pp.577~583 (1987)
- Toro H, "Characterization of fowl adenoviruses from outbreaks of inclusion body hepatitis", hydropericardium syndrome in Chile, 1999, pp.43(2), 262~270
- Van Der Heide L, "Viral arthritis", tenosynovitis: a review, 1977, pp.6(4), 271~284
- Vertommen M, "Infectious stunting and leg weakness in broilers II. Studies on alkaline phosphatase isoenzymes in blood plasma", Avian Pathol, 9(2), pp.143~153 (1980)
- Vertommen M, "Infectious stunting and leg weakness in broilers: I. Pathology and biochemical changes in blood plasma", Avian Pathol, 9(2), pp.133~142 (1980)