The effects of the antiviral agent T-1105 on various serotypes of foot-and-mouth disease virus
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Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals and is caused by the foot-and-mouth disease virus (FMDV), and results in significant economic losses in the livestock industry. The high genetic variability of FMDV poses a substantial challenge to vaccine efficacy. This study evaluates the antiviral efficacy of T-1105, an RNA-dependent RNA polymerase inhibitor, against FMDV. The cytotoxic concentration 50 (CC50) and inhibitory concentration 50 (IC50) of T-1105 were determined, and the sensitivity index (SI) was calculated. Results demonstrated that the SI value of T-1105 was lower than that of ribavirin, a standard antiviral agent. T-1105 exhibited partial antiviral activity against several FMDV subtypes, including O1/Manisa/Turkey/69, O/SKR/2000, A22/Iraq 24/64, A/Malaysia/97, Asia1/Shamir/89, and Asia1/MOG/05, with similar findings observed in RT-PCR assays except for Andong/SKR/2010 and O/SKR/2002. Overall, the antiviral effect of T-1105 exhibited narrow specificity against several serotypes of FMDV.
Abstract
Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals and is caused by the foot-and-mouth disease virus (FMDV), and results in significant economic losses in the livestock industry. The high genetic variability of FMDV poses a substantial challenge to vaccine efficacy. This study evaluates the antiviral efficacy of T-1105, an RNA-dependent RNA polymerase inhibitor, against FMDV. The cytotoxic concentration 50 (CC50) and inhibitory concentration 50 (IC50) of T-1105 were determined, and the sensitivity index (SI) was calculated. Results demonstrated that the SI value of T-1105 was lower than that of ribavirin, a standard antiviral agent. T-1105 exhibited partial antiviral activity against several FMDV subtypes, including O1/Manisa/Turkey/69, O/SKR/2000, A22/Iraq 24/64, A/Malaysia/97, Asia1/Shamir/89, and Asia1/MOG/05, with similar findings observed in RT-PCR assays except for Andong/SKR/2010 and O/SKR/2002. Overall, the antiviral effect of T-1105 exhibited narrow specificity against several serotypes of FMDV.
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