나노 입자화 한 복분자 저온 추출물의 면역 활성 증진
Enhancement of Immuno Modulatory Activities of Rubus coreanus Miquel Extracts by Nano-encapsulation Process
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Abstract
This study was performed to improve immune activities of Rubus coreanus Miquel by encapsulation of nanoparticles. Immuno-activities of R. coreanus were investigated through aqueous extracts associated with process of water at 60℃. It showed high promotion of human B and T cells growth about 50%, compared to the case of other conditions. The secretion of IL-6 and TNF-α was also enhanced as 2.44 × 10−4 pg/cell and 1.94 × 10−4 pg/cell, results by adding nano samples. NK cell activation was improved up to 29% higher than the conventional extraction process. The secretion of NO from macrophage showed 14.9 μM on the nano-encapsulation process extracts, which was higher than others. The size of nanoparticles was in the range of 50~300㎚, which can effect the penetration into the cells. It was clearly observed by real time confocal microscope.
참고문헌 (12)
- Bae GH, "The medical plants Korea", pp.230~231 (2000), Kyohak Publishing Co., Ltd
- Han BH, "Effect of ginsenosides from Panax ginseng on TNF-α production and T cell proliferation", Korean Journal of Pharmaceutical Society, 42, pp.296~301 (1998)
- Noh-Hee Jeong, "Preparation and Characterization of Nano-Liposomes Using Phosphatidylcholine", Journal of Industrial and Engineering Chemistry, 11(6), pp.847~851 (2005), 한국공업화학회
- Kim HC, "A comparative study on the health effect of Rubus coreanum", Journal of Herbal Pharmacotherapy, 6, pp.3~11 (1991)
- Kim DM, "Nano food materials and approchable development of nanofunctional dairy products", Korean Journal of Dairy Technology Science, 22, pp.1~12 (2004)
- 이현용, "저온 추출 공정에 의한 마황과 복분자의 면역 활성 증진 효과", 한국약용작물학회지, 13(3), pp.81~86 (2005), 한국약용작물학회
- 권민철, "병풀의 초음파 추출 시 용매에 따른 면역활성 증진 효과", 한국약용작물학회지, 16(5), pp.294~300 (2008), 한국약용작물학회
- 이희상, "혈액뇌장벽의 치밀이음부에서 H2O2의 occludin 손상에 대한 알파토코페롤의 억제효과", 대한체질인류학회지, 19(3), pp.223~233 (2006), 대한체질인류학회
- 권민철, "초고압 공정에 의한 복분자의 면역조절효능 비교", 한국약용작물학회지, 15(6), pp.398~404 (2007), 한국약용작물학회
- 이현용, "복분자와 당귀 열수추출물의 마우스를 이용한 항암 및 항스트레스 효과", 한국약용작물회지, 14(4), pp.206~211 (2006), 한국약용작물학회
- 이서호, "황칠나무 잎의 면역활성증진기능 탐색", 한국약용작물학회지, 10(2), pp.109~115 (2002), 한국약용작물학회
- Yueran Z, "Expression of leptin recrptor and response to leptin stimulation of human natural killer cell lines", Biochemical and Biophysical Research communications, 300, pp.247~252 (2003)