기억력 손상 마우스에서 흑미 호분층 추출물의 인지능력 개선 효과
Cognitive-enhancing Effects of Black Rice Aleurone Layer Extract on Scopolamine-induced Memory Impairment in Mice
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Background: The aim of this study was to investigate the potential of black rice (Oryza sativa L.) aleurone layer (BR) extract at improving the memory function of scopolamine-induced memory impaired mice. Methods and Results: BR extract (150 and 300 ㎎/㎏), scopolamine (1 ㎎/㎏), and tacrine (10 ㎎/㎏) were administered to C57BL/6 mice. We analyzed the effects of BR extract on the scopolamine-induced cholinergic system, inflammatory response, and brain damage. It was observed that the BR extract offered protection against scopolamine-induced short- and long-term memory loss, and reduced learning deficits in the behavioral task. It also improved the cholinergic system and decreased the inflammatory cytokine levels. Furthermore, the BR extract downregulated the scopolamine-induced overexpression of amyloid β-peptide and caspase-3 in the hippocampus. Conclusions: These results suggest that the BR extract may be beneficial as a dietary supplement, due to its neuroprotective effect against cognitive impairment and cholinergic deficit
Abstract
Background: The aim of this study was to investigate the potential of black rice (Oryza sativa L.) aleurone layer (BR) extract at improving the memory function of scopolamine-induced memory impaired mice. Methods and Results: BR extract (150 and 300 ㎎/㎏), scopolamine (1 ㎎/㎏), and tacrine (10 ㎎/㎏) were administered to C57BL/6 mice. We analyzed the effects of BR extract on the scopolamine-induced cholinergic system, inflammatory response, and brain damage. It was observed that the BR extract offered protection against scopolamine-induced short- and long-term memory loss, and reduced learning deficits in the behavioral task. It also improved the cholinergic system and decreased the inflammatory cytokine levels. Furthermore, the BR extract downregulated the scopolamine-induced overexpression of amyloid β-peptide and caspase-3 in the hippocampus. Conclusions: These results suggest that the BR extract may be beneficial as a dietary supplement, due to its neuroprotective effect against cognitive impairment and cholinergic deficit
참고문헌 (31)
- Apridamayanti P, "Anthocyanin, nutrient contents, and antioxidant activity of black rice bran of Oryza sativa L. ‘Cempo Ireng’ from sleman, yogyakarta, Indonesia", Indonesian Journal of Biotechnology, 22, pp.49~54 (2017)
- Aydin E, "The effects of inhaled Pimpinella peregrina essential oil on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats", Molecular Neurobiology, 53, pp.6557~6567 (2016)
- 배동혁, "Scopolamine으로 유도된 기억력 손상 동물모델에서 비파엽 추출물의 학습 및 기억력 개선 효과", 한국식품영양과학회지, 43(6), pp.799~806 (2014), 한국식품영양과학회
- 조영수, "칼슘 배합 비율에 따른 초석잠의 scopolamine 치매유도 흰쥐에 대한 기억손상 개선 효과", 생명과학회지, 26(7), pp.812~818 (2016), 한국생명과학회
- 최미란, "마우스에서 복분자 물추출물의 기억력 감퇴에 대한 개선 효과", 한국식품영양과학회지, 41(2), pp.192~196 (2012), 한국식품영양과학회
- Gacar N, "Beneficial effects of resveratrol on scopolamine but not mecamylamine induced memory impairment in the passive avoidance and morris water maze tests in rats", Pharmacology Biochemistry and Behavior, 99, pp.316~323 (2011)
- Hritcu L, "Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats", Phytomedicine, 19, pp.529~534 (2012)
- Iqbal S, "Succinamide derivatives ameliorate neuroinflammation and oxidative stress in scopolamine-induced neurodegeneration", Biomolecules, 10, pp.443~ (2020)[DOI]
- Hwan-Hee Jang, "Black rice (Oryza sativa L.) extract attenuates hepatic steatosis in C57BL", 6 J mice fed a high-fat diet via fatty acid oxidation, 2012, pp.9(1), ~[DOI]
- Soo-Hyun Joo, "An Exploration of the Oryza sativa L. Cyanidin-3-glucoside on the Cognitive Function in Older Adults with Subjective Memory Impairment", PSYCHIATRY INVESTIGATION, 16(10), pp.759~765 (2019), 대한신경정신의학회[DOI]
- 강신정, "Scopolamine 유도 치매동물모델에서 고려인삼(백삼, 홍삼 및흑삼)의 기억력 개선 효과", 한국식품영양과학회지, 42(8), pp.1190~1196 (2013), 한국식품영양과학회
- 김지현, "홍화씨와 흰민들레 복합물의 Scopolamine 유도 기억력 손상에 대한 보호 효과", 한국약용작물학회지, 28(2), pp.85~94 (2020), 한국약용작물학회[DOI]
- 공수현, "흑미의 도정분획 메탄올 추출물의 항산화 성분 및 항산화 효과", 한국식품영양과학회지, 37(7), pp.815~819 (2008), 한국식품영양과학회
- Kwon SH, "Neuroprotective effects of chlorogenic acid on scopolamineinduced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice", European Journal of Pharamacology, 649, pp.210~217 (2010)
- Lee JH, "Effects of Leonurus japonicus Houtt. on scopolamine-induced memory impairment in mice", Journal of Physiology and Pathology in Korean Medicine, 32, pp.81~87 (2020)
- 이지혜, "Scopolamine 처리에 의한 인지 및 기억력 손상 마우스에서 박하의 효과", 생약학회지, 51(1), pp.70~77 (2020), 한국생약학회
- 이승은, "인지능 개선 효과 증진을 위한 백삼 추출물 조제 연구", 한국약용작물학회지, 24(5), pp.375~385 (2016), 한국약용작물학회[DOI]
- 이승은, "Leaf Extract of Sedum kamtschaticum Fisch. & Mey. Ameliorates Cognitive Dysfunction in Trimethyltin-treated Rats", 한국약용작물학회지, 29(1), pp.1~10 (2021), 한국약용작물학회[DOI]
- Ling FA, "Protective effect of recombinant human somatotropin on amyloid β-peptide induced learning and memory deficits in mice", Growth Hormone and IGF Research, 17, pp.336~341 (2007)
- McCaulley ME, "Alzheimer’s disease : Exploring the role of inflammation and implications for treatment", International Journal of Alzheimer’s Disease, 2015, pp.515248~ (2015)[DOI]
- Min JY, "Neuroprotective effect of cyanidin-3-O-glucoside anthocyanin in mice with focal cerebral ischemia", Neuroscience Letters, 500, pp.157~161 (2011)
- Muhammad T, "Melatonin rescue oxidative stress-mediated neuroinflammation", neurodegenration and memory impairment in scopolamine-induced amnesia mice model, 2019, pp.14, 278~294
- 박찬규, "Ameliorative Effect of Aster scaber Thunberg and Chaenoleles sinensis Koehne Complex Extracts Against Oxidative Stress-induced Memory Dysfunction in PC12 Cells and ICR Mice", 한국약용작물학회지, 27(6), pp.365~375 (2019), 한국약용작물학회[DOI]
- 박나은, "Scopolamine 유발 기억력 손상 마우스 모델에서 목향(木香)의 기억력 개선 및 항산화 효과", 동의신경정신과학회지, 28(2), pp.123~136 (2017), 대한한방신경정신과학회
- Food composition table, "Rural Development Administration(RDA)", Rural Development Administration, 28~29 (2011)
- 서선정, "여러 가지 특수미의 항산화 활성 및 항산화 성분", 한국식품영양과학회지, 37(2), pp.129~135 (2008), 한국식품영양과학회
- Shaftel SS, "Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology", The Journal of Clinical Investigation, 117, pp.1595~1604 (2007)
- 손기호, "Scopolamine유도 치매쥐에서 산수유 추출물의 항치매 효과", 생약학회지, 48(4), pp.304~313 (2017), 한국생약학회
- Watkins PB, "Hepatotoxic effects of tacrine administration in patients with Alzheimer’s disease", The Journal of the American Medical Association, 271, pp.992~998 (1994)
- Ting Xu, "Water-soluble ginseng oligosaccharides protect against scopolamine-induced cognitive impairment by functioning as an antineuroinflammatory agent", Journal of Ginseng Research, 40(3), pp.211~219 (2016), 고려인삼학회
- Zhang J, "Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside(C3G)in the central nervous system : An outlined review", European Journal of Pharmacology, 858, pp.172500~ (2019)[DOI]