千金延壽丹이 노화 유발된 흰쥐의 항산화효능에 미치는 영향
An Anti-oxidative Effects of Cheongeumyeonsudan on Rats Induced Aging by D-Galactose
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Abstract
Objectives : The purpose of this study is to find out the effect of antioxidation related to aging of Cheongeumyeonsudan which is written on Dongui-bogam experimentally. Method : 14 weeks aged SD albino rats were separated into uncontrolled group, controlled group and CGY group. As controlled and CGY groups were induced aging by subcutaneous injection of D-galactose, at the same time we administered the extract of Cheongeumyeonsudan to CGY group for 6 weeks. After then we drew blood from each group, and took measurements; the activity of SOD, GSH-px, catalase in erythrocytes, TBARS value, concentration of total lipid, tryglyceride, total cholesterol, HDL-cholesterol in blood plasma. Results : The activities of SOD, GSH-px in erythrocytes were significantly increased in the CGY group compared with control group. The activity of catalase showed a tendency to increase, but it was not remarkable. The concentration of total lipid, the values of TBARS and total cholesterol was significantly decreased in the CGY group compared with control group, and the concentration of plasma HDL-cholesterol was not remarkable. The concentrations of tryglyceride in plasma showed a tendency to decrease. Conclusions : it is suggested that Cheongeumyeonsudan decrease the activities of free radical, the concentrations of lipid in plasma and generate enzyme which form lipid peroxide.
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