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사염화탄소로 간 손상이 유발된 흰쥐에서 황금(黃芩) 열수 추출물이 면역작용에 미치는 효과

The Protective Effects of Scutellaria baicalensis Georgi Water Extracts on the Immunomodulatory Effects on Liver Damage Induced by Carbon Tetrachloride in Rats

김해란|전윤희|임병우|안치선
한국약용작물학회|2009.08|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제17권 제4호|pp. 273-279

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Abstract

GATA-binding protein-3 (GATA-3) and T-box expressed in T-cells (T-bet) are now considered as master transcription factors involving Th cell differentiation, but the roles of these factors are still uncertain in vivo. This study was conducted to investigate the expression of these transcription factors in the liver damage induced by carbon tetrachloride (CCl4) in rats. In this study, liver damage were induced with Scutellaria baicalensis Georgi water extracts (SBW) and followed for 4 weeks. The expression of GATA-3 and T-bet protein in liver damage induced by CCl4 and the serum levels of immunoglobulin A (IgA), IgE were studied after 4 weeks of treatment. We found that effect of SBW on IFN-γ, STAT1, pSTAT1 and T-bet was decreased in vivo. Several genes were demonstrated to be IL-4 inducible prior to the discovery of STAT6. CCl4+SBW group was significantly lower than CCl4 group in IL-4, STAT6, pSTAT6 and GATA-3. Our data indicate that cytokine protein production were increased in CCl4 group and CCl4+SBW group. From these results, water extracts obtained from Scutellaria baicalensis Georgi may have an immunoregulatory effect in the liver induced by CCl4 of rats.

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