양마에서 분리한 Kaempferol 및 그 배당체의 항염증 효과에 관한 연구
Study on the Anti-inflammatory Effect of Kaempferol and Kaempferol Rhamnosides Isolated from Hibiscus cannabinus L.
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In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin (PGE_2), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and PGE_2. Kaempferol and α-rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, α-rhamnoisorobin and afzelin Inhibited the release of PGE_2 . Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.
Abstract
In this study, to evaluate the anti-inflammatory effects of kaempferol and its rhamnosides isolated from Hibiscus cannabinus L. leaves, we investigated UVB-induced inhibitory effects on inflammatory reaction by measuring the cytokine as the prostaglandin (PGE_2), interleukine-6 (IL-6) and interleukine-8 (IL-8). We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC (thymus and activation-regulated chemokine) and PGE_2. Kaempferol and α-rhamnoisorobin showed inhibition activity of TARC generated to compared to positive control. Kaempferol, α-rhamnoisorobin and afzelin Inhibited the release of PGE_2 . Also, only kaempferol significantly inhibited interleukine-6 (IL-6), interleukine-8 (IL-8) among UVB-induced inflammatory cytokine.
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