초고압 공정을 이용한 강황 잎 추출물의 피부 면역 활성 증진
Enhancement of Skin Immune Activities of Curcuma longa L. Leaf Extract by Ultra High Pressure Process
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초록
Curcuma longa L. leaf was extracted by water at 60℃ for 12 hours after being treatment of Ultra HighPressure under 500 MPa for 5-15 minute. The high pressure extraction for 15 minute (HPE15) was measured the highestextraction yield of 25.48% (w/w), compared to those from conventional extraction methods. The HPE15 showed the lowestcytotoxicity as 11.97% in adding 1.0 ㎎/㎖ of concentration. Also, HPE15 was measured the highest inhibition of hyaluronidaseas 44.48% in adding 1.0 ㎎/㎖. In addition, The production of NO from macrophages was measured as 7.06 μM in adding1.0 ㎎/㎖ of HPE15, which was lower than the those from others processes. Finally, HPE15 significantly reduced up to649.44 pg/㎖ of ProstaglandinE2 production from UV-irradiation. These results suggest that the Curcuma longa Linne leafextract from high pressure process might enhance the skin immune activities possibly by high elution of active componentsthan other processes.
Abstract
Curcuma longa L. leaf was extracted by water at 60℃ for 12 hours after being treatment of Ultra HighPressure under 500 MPa for 5-15 minute. The high pressure extraction for 15 minute (HPE15) was measured the highestextraction yield of 25.48% (w/w), compared to those from conventional extraction methods. The HPE15 showed the lowestcytotoxicity as 11.97% in adding 1.0 ㎎/㎖ of concentration. Also, HPE15 was measured the highest inhibition of hyaluronidaseas 44.48% in adding 1.0 ㎎/㎖. In addition, The production of NO from macrophages was measured as 7.06 μM in adding1.0 ㎎/㎖ of HPE15, which was lower than the those from others processes. Finally, HPE15 significantly reduced up to649.44 pg/㎖ of ProstaglandinE2 production from UV-irradiation. These results suggest that the Curcuma longa Linne leafextract from high pressure process might enhance the skin immune activities possibly by high elution of active componentsthan other processes.
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