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아스파라거스 부산물 추출물의 숙취 해소 및 통풍완화 효과

Anti-hangover and Anti-gout Effects of Asparagus Byproduct Extracts

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Background: Given the reported pharmacological effects of rutin from asparagus stems and roots, here, we assessed the anti-hangover and anti-gout effects of asparagus stem and root extracts. Methods and Results: We found that rutin amount in ethanol extracts of asparagus stems was 10.15 ㎎/g, and in hydrothermal extracts of asparagus roots it was 3.28 ㎎/g. Alcohol dehydrogenase and aldehyde dehydrogenase activities in asparagus-stem extracts were 80% and 40% of those in the control group, respectively. Following hangover induction in rats using alcohol, an injection of 400 ㎎/㎏ body weight (BW) of the extract significantly reduced the blood alcohol concentration compared to that of the control group. Additionally, blood gamma-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) concentrations measured 5 h after alcohol administration revealed that treatment with 400 ㎎/㎏ BW of extract significantly reduced GGT and GOT concentrations compared to the control group, whereas changes in GPT were not significant. Moreover, xanthine oxidase activity after treatment with hydrothermal extracts of asparagus roots was 44.01 ± 0.32%, showing 53.3% inhibition compared to the positive control (allopurinol; 82.50 ± 4.98%). To assess the anti-gout effect of hydrothermal extracts of asparagus roots, we induced gout in rats by intraperitoneal injection of potassium oxonate and measured blood uric acid, creatinine, and blood urea nitrogen concentrations at 3 h post-administration of the extract. The results showed a significant reduction in creatinine and uric acid levels in the treated group compared to the control. Conclusions: These findings demonstrated the potential of asparagus stem and root extracts as functional ingredients.

Abstract

Background: Given the reported pharmacological effects of rutin from asparagus stems and roots, here, we assessed the anti-hangover and anti-gout effects of asparagus stem and root extracts. Methods and Results: We found that rutin amount in ethanol extracts of asparagus stems was 10.15 ㎎/g, and in hydrothermal extracts of asparagus roots it was 3.28 ㎎/g. Alcohol dehydrogenase and aldehyde dehydrogenase activities in asparagus-stem extracts were 80% and 40% of those in the control group, respectively. Following hangover induction in rats using alcohol, an injection of 400 ㎎/㎏ body weight (BW) of the extract significantly reduced the blood alcohol concentration compared to that of the control group. Additionally, blood gamma-glutamyl transpeptidase (GGT), glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) concentrations measured 5 h after alcohol administration revealed that treatment with 400 ㎎/㎏ BW of extract significantly reduced GGT and GOT concentrations compared to the control group, whereas changes in GPT were not significant. Moreover, xanthine oxidase activity after treatment with hydrothermal extracts of asparagus roots was 44.01 ± 0.32%, showing 53.3% inhibition compared to the positive control (allopurinol; 82.50 ± 4.98%). To assess the anti-gout effect of hydrothermal extracts of asparagus roots, we induced gout in rats by intraperitoneal injection of potassium oxonate and measured blood uric acid, creatinine, and blood urea nitrogen concentrations at 3 h post-administration of the extract. The results showed a significant reduction in creatinine and uric acid levels in the treated group compared to the control. Conclusions: These findings demonstrated the potential of asparagus stem and root extracts as functional ingredients.

참고문헌 (34)

  1. Al-SnafiAE, "The pharmacological importance of Asparagus officinalis–A review", Journal of Pharmaceutical Biology, 5, pp.93~98 (2015)
  2. Chitrakar B, "Asparagus(Asparagus officinalis) : Processing effect on nutritional and phytochemical composition of spear and hard-stem byproducts", Trends in Food Science and Technology, 93, pp.1~11 (2019)
  3. Elsaid FG, "Role of Matricaria recutita L. and Asparagus officinalis L. against the neurotoxicity of diazinon in rats", Journal of Basic and Applied Zoology, 72, pp.26~35 (2015)
  4. Fadda A, "Influence of pH, buffers and role of quinolinic acid, a novel iron chelating agent, in the determination of hydroxyl radical scavenging activity of plant extracts by electron paramagnetic resonance(EPR)", Food Chemistry, 240, pp.174~182 (2018)
  5. Fan R, "Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L", Journal of Food Science and Technology, 52, pp.2690~2700 (2015)
  6. Fusi F, "Effects of quercetin and rutin on vascular preparations : A comparison between mechanical and electrophysiological phenomena", European Journal of Nutrition, 42, pp.10~17 (2003)
  7. Jang DS, "Constituents of Asparagus officinalis evaluated for inhibitory activity against cyclooxygenase-2", Journal of Agricultural and Food Chemistry, 52, pp.2218~2222 (2004)
  8. 정민숙, "무 에탄올 추출물의 in vitro 생리활성 분석", Applied Biological Chemistry, 47(1), pp.67~71 (2004), 한국응용생명화학회
  9. Kahlon TS, "In vitro binding of bile acids by okra, beets, asparagus, eggplant, turnips, green beans, carrots, and cauliflower", Food Chemistry, 103, pp.676~680 (2007)
  10. 기주영, "알코올 대사 효소들의 유전적 다형성이 음주 행태 및 간경변증 발생에 미치는 영향", Clinical and Molecular Hepatology, 9(2003), pp.89~97 (2003), 대한간학회
  11. 김정상, "갈근(Radix puerariae)과 죽력(Bambusae caules in Liquamen Phyllostachyos)을 함유한 숙취해소 음료가 알코올을 투여한 생쥐에 미치는 영향", 한국식품영양과학회지, 33(2), pp.318~323 (2004), 한국식품영양과학회
  12. Kim OK, "Inhibition of xanthine oxidase by seaweed extracts", Journal of the Korean Society of Food Science and Nutrition, 25, pp.1069~1073 (1996)
  13. 권순배, "아스파라거스 부위별 유효성분 및 생리활성 분석", 한국식품과학회지, 52(1), pp.67~74 (2020), 한국식품과학회
  14. 이준, "흑홍삼혼합물이 체내 알코올대사에 미치는 효과", 한국식품영양학회지, 29(5), pp.655~662 (2016), 한국식품영양학회
  15. 이종원, "아스파라거스 4 품종의 생장, 휴면타파, 수량 및 추출물의 생리활성 비교", 원예과학기술지, 33(5), pp.796~804 (2015), 한국원예학회
  16. 임애경, "Bulnesia sarmienti 를 함유한 숙취해소 음료가 알코올대사 및 항산화 효소활성에 미치는 영향", Food Science and Preservation, 18(3), pp.407~413 (2011), 한국식품저장유통학회
  17. Maeda T, "Light condition influences rutin and polyphenol contents in asparagus spears in the mother-fern culture system during the summer-autumn harvest", Journal of the Japanese Society for Horticultural Science, 79, pp.161~167 (2010)
  18. Maeda T, "Antioxidation capacities of extracts from green, purple, and white asparagus spears related to polyphenol concentration", HortScience, 40, pp.1221~1224 (2005)
  19. Martin-Belloso O, "Proximate composition, minerals and vitamins in selected canned vegetables", European Food Research and Technology, 212, pp.182~187 (2001)
  20. Motoki S, "Improving the yield of the purple asparagus cultivar ‘Purple Passion’ by high density planting", Acta Horticulturae, 950, pp.117~124 (2012)
  21. Motoki S, "Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls", Bioscience, Biotechnology, and Biochemistry, 76, pp.1047~1050 (2012)
  22. Ngu yen MTT, "Xanthine oxidase inhibitory activity of Vietnamese medicinal plants", Biological and Pharmaceutical Bulletin, 27, pp.1414~1421 (2004)
  23. "An analysis of the supply and demand status of western vegetables and tasks" (2016)[URL]
  24. 성기철, "아스파라거스의 품종간 생육특성 비교와 비가림, 멀칭에 의한 생산성 향상 효과", 생물환경조절학회지, 10(3), pp.187~196 (2001), (사) 한국생물환경조절학회
  25. 신유진, "한약재 열수추출물의 항산화 활성 및 Xanthine Oxidase 저해 활성", 한국식품영양과학회지, 42(10), pp.1712~1716 (2013), 한국식품영양과학회
  26. Stirpe F, "The regulation of rat liver xanthine oxidase : Conversion in vitro of the enzyme activity from dehydrogenase(Type D)to oxidase(Type O)", Journal of Biological Chemistry, 244, pp.3855~3863 (1969)
  27. Storch J, "Detergent-amplified chemiluminescence of lucigenin for determination of superoxide anion production by NADPH oxidase and xanthine oxidase", Analytical Biochemistry, 169, pp.262~267 (1998)
  28. Su llivan SA, "Asparagus polysaccharide inhibits cell proliferation, adhesion and invasion in endometrial cancer cells", Gynecologic Oncology, 145, pp.133~133 (2017)
  29. Symes A, "Antioxidant activities and caffeic acid content in New Zealand Asparagus(Asparagus officinalis)roots extracts", Antioxidants, 7, pp.52~ (2018)[DOI]
  30. Tsushida T, "Evaluation of antioxidant activity of vegetable extracts and determination of some active compounds", Nippon Shokuhin Kogyo Gakkaishi, 41, pp.611~618 (1994)
  31. Wang M, "Quantification of protodioscin and rutin in asparagus shoots by LC", MS and HPLC methods, 2003, pp.51, 6132~6136
  32. Wang N, "Structural characterisation and immunomodulatory activity of polysaccharides from white asparagus skin", Carbohydrate Polymer, 227, pp.115314~ (2020)[DOI]
  33. Xiong D, "Effects of root and stem extracts of Asparagus cochinchinensis on biochemical indicators related to aging in the brain and liver of mice", American Journal of Chinese Medicine, 39, pp.719~726 (2011)
  34. Zhang H, "Phytochemical compounds and biological activity in asparagus roots : A review", International Journal of Food Science and Technology, 54, pp.966~977 (2019)

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