식물 유래 항암제와 생산 개선을 위한 식물 합성생물학 연구 동향

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참고문헌 (152)

1. Alam MA, "Impact of soil nutrients and environmental factors on podophyllotoxin content among 28 populations of Podophyllum Hexandrum", Communications in Soil Science and Plant Analysis, 40, pp.2485~2504 (2009)
2. Amna T, "Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin", Canadian Journal of Microbiology, 52, pp.189~196 (2006)
3. Anterola A, "Production of taxa-4(5), 11(12)-diene by transgenic Physcomitrella patens", Transgenic Research, 18, pp.655~660 (2009)
4. Ardalani H, "Podophyllotoxin : A novel potential natural anticancer agent", Avicenna Journal of Phytomedicine, 7, pp.285~294 (2017)
5. Asano T, "Camptothecin production by in vitro cultures and plant regeneration in Ophiorrhiza species", Methods in Molecular Biology, 547, pp.337~345 (2009)
6. Ayres DC, "Lignans. Chemical, biological and clinical properties", pp.5~86 (1990), Cambridge University Pres
7. 배대호, "희수나무 캘러스로부터 기관분화에 의한 식물체 재분화", 한국약용작물학회지, 17(3), pp.192~197 (2009), 한국약용작물학회
8. Bahabadi SE, "Time-course changes in fungal elicitor-induced lignan synthesis and expression of the relevant genes in cell cultures of Linum album", Journal of Plant Physiology, 169, pp.487~491 (2012)
9. "Irinotecan: 25 years of cancer treatment" (2019)[URL]
10. Besumbes Ó, "Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol", Biotechnology and Bioengineering, 88, pp.168~175 (2004)
11. Bray F, "Global cancer statistics 2018 : GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries", CA : A Cancer Journal for Clinicians, 68, pp.394~424 (2018)
12. Bringi V, "Enhanced production of taxol and taxanes by cell cultures of Taxus species", USA. Patent. 5,407,816, 816~ (1995)
13. Brown S, "De novo production of the plant-derived alkaloid strictosidine in yeast", Proceedings of the National Academy of Sciences, 112, pp.3205~3210 (2015)
14. Butler MS, "The role of natural product chemistry in drug discovery", Journal of Natural Products, 67, pp.2141~2153 (2004)
15. Caputi L, "Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle", Science, 360, pp.1235~1239 (2018)
16. Mijeong Cha, "Production of taxadiene from cultured ginseng roots transformed with taxadiene synthase gene", BMB Reports, 45(10), pp.589~594 (2012), 생화학분자생물학회
17. Chang C, "A bZIP transcription factor, CaLMF, mediated light-regulated camptothecin biosynthesis in Camptotheca acuminata", Tree Physiology, 39, pp.372~380 (2018)
18. "Phytochemicals in cancer treatment: From preclinical studies to clinical practice" (2020)[URL]
19. "Repeated evolution of cytochrome P450-mediated spiroketal steroid biosynthesis in plants" (2019)[URL]
20. Costa MMR, "Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anitcancer alkaloids in Catharanthus roseus", Plant Physiology, 146, pp.403~417 (2008)
21. Courdavault V, "Metabolic engineering for plant natural products biosynthesis : New procedures, concrete achievements and remaining limits", Natural Product Reports, 38, pp.2145~2153 (2021)
22. Davin LB, "Stereoselective bimolecular phenoxy radical coupling by an auxiliary(dirigent)protein without an active center", Science, 275, pp.362~366 (1997)
23. De La Peña R, "Rerouting plant terpene biosynthesis enables momilactone pathway elucidation", Nature Chemical Biology, 17, pp.205~212 (2021)
24. Dinkova-Kostova AT, "(+)-Pinoresinol", (-)-Lariciresinol Reductase from Forsythia intermedia. Protein purification, cDNA cloning, heterologous expression and comparison to isoflavone reductase, 1996, pp.271, 29473~29482
25. Farhi M, "Generation of the potent anti-malarial drug artemisinin in tobacco", Nature Biotechnology, 29, pp.1072~1074 (2011)
26. Farkya S, "Exogenous hormones affecting morphology and biosynthetic potential of hairy root line(LYR2i)of Linum album", Journal of Bioscience and Bioengineering, 105, pp.140~146 (2008)
27. Fett-Neto AG, "Cell culture of Taxus as a source of the antineoplastic drug taxol and related taxanes", Biotechnology, 10, pp.1572~1575 (1992)
28. Galanie S, "Complete biosynthesis of opioids in yeast", Science, 349, pp.1095~1100 (2015)
29. "Status and challenges of plant-anticancer compounds in cancer treatment" (2021)[URL]
30. Geerlings A, "Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus", Journal of Biological Chemistry, 275, pp.3051~3056 (2000)
31. Goldin A, "Experimental screening procedures and clinical predictability value", Cancer Chemotherapy Reports, 50, pp.172~218 (1966)
32. Gordaliza M, "Antitumor properties of podophyllotoxin and related compounds", Current Pharmaceutical Design, 6, pp.1811~1839 (2000)
33. Grellier P, "Selective and reversible effects of vinca alkaloids on trypanosoma cruzi epimastigote forms : Blockage of cytokinesis without inhibition of the organelle duplication", Cell Motility and the Cytoskeleton, 42, pp.36~47 (1999)
34. "The transcription factor OpWRKY2 positively regulates the biosynthesis of the anticancer drug camptothecin in Ophiorrhiza pumila" (2021)[URL]
35. Hasan MM, "Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene", Plant Cell Reports, 33, pp.895~904 (2014)
36. "Methyl jasmonate regulates podophyllotoxin accumulation in Podophyllum hexandrum by altering the ROS-Responsive podophyllotoxin pathway gene expression additionally through the down regulation of few interfering miRNAs" (2017)[URL]
37. He L, "A common pharmacophore for Taxol and the epothilones based on the biological activity of a taxane molecule lacking a C-13 side chain", Biochemistry, 39, pp.3972~3978 (2000)
38. Hefner J, "Cytochrome P450-catalyzed hydroxylation of taxa-4(5), 11(12)-diene to taxa-4(20), 11(12)-dien-5alpha-ol : The first oxygenation step in taxol biosynthesis", Chemistry and Biology, 3, pp.479~489 (1996)
39. Hezari M, "Taxol biosynthesis : An update", Planta Medica, 63, pp.291~295 (1997)
40. Hong SB, "Expression of the Arabidopsis feedback-insensitive anthranilate synthase holoenzyme and tryptophan decarboxylase genes in Catharanthus roseus hairy roots", Journal of Biotechnology, 122, pp.28~38 (2006)
41. Huang TS, "A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells", Pharmaceutical Research, 16, pp.997~1002 (1999)
42. Hughes EH, "Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine", Metabolic Engineering, 6, pp.268~276 (2004)
43. Islas I, "Tryptophan decarboxylase activity in transformed roots from Catharanthus roseus and its relationship to tryptamine, ajmalicine, and catharanthine accumulation during the culture cycle", In Vitro Cellular and Developmental Biology, 30, pp.81~83 (1994)
44. Jeong WT, "A UPLC-ESI-Q-TOF method for rapid and reliable identification and quantification of major indole alkaloids in Catharanthus roseus", Journal of Chromato-graphy B : Analytical Technologies in the Biomedical and Life Sciences, 1080, pp.27~36 (2018)
45. 김영, "초고압 저온처리에 의한 매자나무의 면역 활성", 한국약용작물학회지, 16(6), pp.439~445 (2008), 한국약용작물학회
46. Joel S, "The clinical pharmacology of etoposide : An update", Cancer Treatment Reviews, 22, pp.179~221 (1996)
47. Jordan A, "Tubulin as a target for anticancer drugs : agents which interact with the mitotic spindle", Medicinal Research Reviews, 18, pp.259~296 (1998)
48. Kai G, "Biosynthesis and biotechnological production of anti-cancer drug Camptothecin", Phytochemistry Reviews, 14, pp.525~539 (2015)
49. Kai GY, "Effect of three plant hormone elicitors on the camptothecin accumulation and gene transcript profiling in Camptotheca acuminata seedlings", International Journal of Sciences, 3, pp.86~95 (2014)
50. Kaplan IW, "Condylomata acuminata", New Orleans Medical and Surgical Journal, 94, pp.388~390 (1942)
51. Kelling J, "Suppression of centromere dynamics by Taxol® in living osteosarcoma cells", Cancer Research, 63, pp.2794~2801 (2003)
52. King LS, "The similarity of the effect of podophyllin and colchicine and their use in the treatment of Condylomata acuminata", Science, 104, pp.244~245 (1946)
53. Kingston DGI, "Recent advances in the chemistry of taxol", Journal of Natural Products, 63, pp.726~734 (2000)
54. Kotopka BJ, "Synthetic biology strategies toward heterologous phytochemical production", Natural Product Reports, 35, pp.902~920 (2018)
55. in transgenic tomato fruit, "Transgenic Research", 2007, 121~126
56. Kuhn M, "Podophyllum lignane : Struktur und absolutkonfiguration von podorhizol-β-D-glucosid(= Lignan F)", Helvetica Chimica Acta, 50, pp.1546~1565 (1967)
57. Kumar P, "Expression analysis of biosynthetic pathway genes vis-à-vis podophyllotoxin content in Podophyllum hexandrum Royle", Protoplasma, 252, pp.1253~1262 (2015)
58. Lahlou M, "Screening of natural products for drug discovery", Expert Opinion on Drug Discovery, 2, pp.697~705 (2007)
59. Lahlou M, "The success of natural products in drug discovery", Pharmacology and Pharmacy, 4, pp.17~31 (2013)
60. Lau W, "Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone", Science, 349, pp.1224~1228 (2015)
61. Lee CC, "A novel topoisomerase GL331 preferentially induces DNA cleavage at(C", G)T sites and can cause telomere DNA damage, 2001, pp.18, 846~851
62. 이희경, "일일초 품종 및 부위별 메탄올 추출물 활성 비교", 한국약용작물학회지, 10(3), pp.212~216 (2002), 한국약용작물학회
63. Lee WL, "Phytoagents for cancer management : Regulation of nucleic acid oxidation, ROS, and related mechanisms", Oxidative Medicine and Cellular Longevity, 2013, pp.925804~ (2013)[DOI]
64. "Chloroplastic metabolic engineering coupled with isoprenoid pool enhancement for committed taxanes biosynthesis in Nicotiana benthamiana" (2019)[URL]
65. Li MF, "Relationship between podophyllotoxin accumulation and soil nutrients and the influence of Fe2+ and Mn2+ on podophyllotoxin biosynthesis in Podophyllum hexandrum tissue culture", Plant Physiology and Biochemistry, 71, pp.96~102 (2013)
66. Liu DH, "Enhanced accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots by overexpression of transcriptional factor ORCA2", African Journal of Biotechnology, 10, pp.3260~3268 (2011)
67. Liu W, "Plant synthetic biology", Trends in Plant Science, 20, pp.309~317 (2015)
68. "Advances in exploring alternative Taxol sources" (2016)[URL]
69. Liu YQ, "Perspectives on biologically active camptothecin derivatives", Medicinal Research Reviews, 35, pp.753~789 (2015)
70. Lorence A, "Camptothecin, over four decades of surprising findings", Phytochemistry, 65, pp.2735~2749 (2004)
71. Lu L, "Com-bination of baicalein and docetaxel additively inhibits the growth of non-small cell lung cancer in vivo", Traditional Medicine and Modern Medicine, 1, pp.213~218 (2018)
72. "Plant metabolic engineering strategies for the production of pharmaceutical terpenoids" (2016)[URL]
73. Luo X, "Complete biosynthesis of cannabinoids and their unnatural analogues in yeast", Nature, 567, pp.123~126 (2019)
74. "National survey on the effect of oncology drug shortages in clinical practice: A hematology oncology pharmacy association survey" (2022)[URL]
75. Natural products from plant cell cultures, "McCoy E", Progress in Drug Research, 329~370 (2008)
76. Menhard B, "Purification and characterization of acetyl coenzyme A : 10-hydroxytaxane O-acetyltransferase from cell suspension cultures of Taxus chinensis", Phytochemistry, 50, pp.763~774 (1999)
77. "Sustainable production of camptothecin from an Alternaria sp. isolated from Nothapodytes nimmoniana" (2021)[URL]
78. Moudi M, "Vinca alkaloids", International Journal of Preventive Medicine, 4, pp.1231~1235 (2013)
79. Mross K, "Pharmaco-kinetics and pharmacodynamics of the new podophyllotoxin derivative NK 611. A study by the AIO groups PHASE-I and APOH", Cancer Chemotherapy and Pharmacology, 38, pp.217~224 (1996)
80. Muranaka T, "Production of podophyllotoxin in Juniperus chinensis callus cultures treated with oligosaccharides and a biogenetic precursor in honour of Professor GH Neil Towers 75th Birthday", Phytochemistry, 49, pp.491~496 (1998)
81. "Recent advances in metabolic engineering, protein engineering, and transcriptome- guided insights toward synthetic production of taxol" (2021)[URL]
82. Nadeem M, "Propagation and conservation of Podophyllum hexandrum Royle : an important medicinal herb", Biological Conservation, 92, pp.121~129 (2000)
83. Newman DJ, "Natural products as sources of new drugs from 1981 to 2014", Journal of Natural Products, 79, pp.629~661 (2016)
84. Nirmala MJ, "Natural plant resources in anti-cnacer therapy-A review", Research in Plant Biology, 1, pp.1~14 (2011)
85. Nobili S, "Vinorelbine in non-small cell lung cancer : real-world data from a single-institution experience", Oncology Research, 28, pp.237~248 (2020)
86. O’Connor SE, "Chemistry and biology of monoterpene indole alkaloid biosynthesis", Natural Product Reports, 23, pp.532~547 (2006)
87. Onrubia M, "Bioprocessing of plant in vitro systems for the mass production of pharmaceutically important metabolites : Paclitaxel and its derivatives", Current Medicinal Chemistry, 20, pp.880~891 (2013)
88. Oudin A, "Spatial distribution and hormonal regulation of gene products from methyl erythritol phosphate and monoterpene-secoiridoid pathways in Catharanthus roseus", Plant Molecualr Biology, 65, pp.13~30 (2007)
89. "Unravelling the anticancer mechanisms of traditional herbal medicines with metabolomics" (2021)[URL]
90. Pan Q, "Overexpression of ORCA3 and G10H in Catharanthus roseus plants regulated alkaloid biosynthesis and metabolism revealed by NMR-metabolomics", PLoS One, 7, pp.1~14 (2012)[DOI]
91. Pant B, "Infectious diseases and nanomedicine II. Advances in experimental medicine and biology", pp.25~39 (2014), Springer
92. Pi Y, "Examination of camptothecin and 10-hydroxycamptothecin in Camptotheca acuminata plant and cell culture, and the affected yields under several cell culture treatments", Biocell, 34, pp.139~143 (2010)
93. Pouvreau B, "From plant metabolic engineering to plant synthetic biology : The evolution of the design", build, learn cycle, pp.Plant Science, 2018[DOI]
94. Priyadarshini K, "Paclitaxel against cancer : A short review", Medicinal Chemistry, 2, pp.139~141 (2012)
95. Pu X, "Possible clues for camptothecin biosynthesis from the metabolites in camptothecin-producing plants", Fitoterapia, 134, pp.113~128 (2019)
96. Pugh NI, "Podophyllotoxin lignans enhance IL-1β but suppress TNF-α mRNA expression in LPS-treated monocytes", Immunopharmacology and Immunotoxicology, 23, pp.83~95 (2001)
97. Raveendran VV, "Camptothecin-discovery, clinical perspectives and biotechnology", Natural Products Chemistry and Research, 3, pp.175~ (2015)
98. Reed J, "Engineering terpenoid production through transient expression in Nicotiana benthamiana", Plant Cell Reports, 37, pp.1431~1441 (2018)
99. Rizvi NF, "An efficient transformation method for estrogen-inducible transgene expression in Catharanthus roseus hairy roots", Plant Cell Tissue and Organ Culture, 120, pp.475~487 (2015)
100. Ro DK, "Production of the antimalarial drug precursor artemisinic acid in engineered yeast", Nature, 440, pp.940~943 (2006)
101. Robles SJ, "Permanent cell cycle arrest in asynchronously proliferating normal human fibroblasts treated with doxorubicin or etoposide but not camptothecin", Biochemical Pharmacology, 58, pp.675~685 (1999)
102. Rohani ER, "An MYB transcription factor regulating specialized metabolisms in Ophiorrhiza pumila", Plant Biotechnology, 33, pp.1~9 (2016)
103. Rong Y, "Co-administration of sulforaphane and doxorubicin attenuates breast cancer growth by preventing the accumulation of myeloid-derived suppressor cells", Cancer Letters, 493, pp.189~196 (2020)
104. Rutschmann J, "Ueber säurehydrazide aus der podophyllotoxin-reihe", Helvetica Chimica Acta, 42, pp.890~907 (1959)
105. Sabzehzari M, "Phyto-miRNAs-based regulation of metabolites biosynthesis in medicinal plants", Gene, 682, pp.13~24 (2019)
106. "Alternative sources and metabolic engineering of Taxol: Advances and future perspectives" (2020)[URL]
107. Sadre R, "Metabolite diversity in alkaloid biosynthesis : A multilane(diastereomer)highway for camptothecin synthesis in Camptotheca acuminata", Plant Cell, 28, pp.1926~1944 (2016)
108. "A novel hydroxylation step in the taxane biosynthetic pathway: A new approach to paclitaxel production by synthetic biology" (2020)[URL]
109. Schacter L., "Etoposide phosphate: What, why, where, and how?", Seminars in Oncology, 23, pp.1~7 (1996)
110. SchiffPB, "Promotion of microtubule assembly in vitro by taxol", Nature, 277, pp.665~667 (1979)
111. Schoendorf A, "Molecular cloning of a cytochrome P450 taxane 10 beta-hydroxylase cDNA from Taxus and functional expression in yeast", Proceedings of the National Academy of Sciences, 98, pp.1501~1506 (2001)
112. Schultz BJ, "Total biosynthesis for milligram-scale production of etoposide intermediates in a plant chassis", Journal of the American Chemical Society, 141, pp.19231~19235 (2019)
113. "Podophyllotoxin: History, recent advances and future prospects" (2021)[URL]
114. Sharma A, "Overexpression of tryptophan decarboxylase and strictosidine synthase enhanced terpenoid indole alkaloid pathway activity and antineoplastic vinblastine biosynthesis in Catharanthus roseus", Protoplasma, 255, pp.1281~1294 (2018)
115. Shi M, "Targeted metabolic engineering of committed steps improves anti-cancer drug camptothecin production in Ophiorrhiza pumila hairy roots", Industrial Crops and Products, 148, pp.112277~ (2020)
116. Sottomayor M, "The vinca alkaloids : From biosynthesis and accumulation in plant cells, to uptake, activity and metabolism in animal cells", Studies in Natural Products Chemistry, 33, pp.813~857 (2006)
117. Stähelin H, "From podophyllotoxin glucoside to etoposide", Progress in Drug Research, 33, pp.169~266 (1989)
118. Stevens LH, "Subcellular localization of tryptophan decarboxylase, strictosidine synthase and strictosidine glucosidase in suspension cultured cells of Catharanthus roeus and Tabernaemontana divaricata", Plant Cell Reports, 12, pp.573~576 (1993)
119. Stoll A, "The isolation of podophyllotoxin glucoside", Journal of the American Chemical Society, 76, pp.3103~3104 (1954)
120. Stoll A, "The isolation of α-peltatin glucoside from the rhizomes of Podophyllum peltatum L", Journal of the American Chemical Society, 77, pp.1709~1710 (1955)
121. "systematic analysis of FDA-approved anticancer drugs" (2017)[URL]
122. Swain SM, "A phase II trial of paclitaxel(Taxol)as first line treatment in advanced breast cancer", Investigational New Drugs, 13, pp.217~222 (1995)
123. Tong Y, "Biosynthesis of paclitaxel using synthetic biology", Phytochemistry Reviews, 21, pp.863~877 (2021)
124. "Function of AP2/ERF transcription factors involved in the regulation of specialized metabolism in Ophiorrhiza pumila revealed by transcriptomics and metabolomics" (2016)[URL]
125. van Hengel AJ, "Characterization of callus formation and camptothecin production by cell lines of Camptotheca acuminata", Plant Cell, Tissue and Organ Culture, 28, pp.11~18 (1992)
126. van Uden W, "The accumulation of podophyllotoxin-β-D-glucoside by cell suspension cultures derived from the conifer Callitris drummondii", Plant Cell Reports, 9, pp.257~260 (1990)
127. van Uden W, "Detection and identification of Podophyllotoxin produced by cell cultures derived from Podophyllum hexandrum royle", Plant Cell Reports, 8, pp.165~168 (1989)
128. von Wartburg A, "Lignanglucoside aus Podophyllum peltatum L", Helvetica Chimica Acta, 40, pp.1331~1357 (1957)
129. Walker K, "Molecular cloning of a 10-deacetylbaccatin III-10-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli", Proceedings of the National Academy of Sciences, 97, pp.583~587 (2000)
130. Walker K, "Taxol biosynthesis : molecular cloning of a benzoyl-CoA : taxane 2alpha-O-benzoyltransferase cDNA from Taxus and functional expression in Escherichia coli", Proceedings of the National Academy of Sciences, 97, pp.13591~13596 (2000)
131. Walker K, "Molecular cloning of a taxa-4(20), 11(12)-dien-5alpha-ol-O-acetyl transferase cDNA from Taxus and functional expression in Escherichia coli", Archives of Biochemistry and Biophysics, 374, pp.371~380 (2000)
132. Walker KD, "Cloning, heterologous expression, and characterization of a phenylalanine aminomutase involved in Taxol biosynthesis", Journal of Biological Chemistry, 279, pp.53947~53954 (2004)
133. Wall ME, "Plant antitumor agents. I. The isolation and structure of camptothecin, a novel alkaloidal leukemia and tumor inhibitor from Camptotheca acuminate", Journal of the American Chemical Society, 88, pp.3887~3890 (1966)
134. Wang C, "Transcription factor OpWRKY3 is involved in the development and biosynthesis of camptothecin and its precursors in Ophiorrhiza pumila hairy roots", Interntional Journal of Molecular Sciences, 20, pp.3996~ (2019)[DOI]
135. Wang Q, "Development of efficient Catharanthus roseus regeneration and transformation system using Agrobacterium tumefaciens and hypocotyls as explants", BMC Biotechology, 12, pp.34~46 (2012)
136. Wankhede DP, "Expressed sequence tags and molecular cloning and characterization of gene encoding pinoresinol", lariciresinol reductase from Podophyllum hexandrum, 2013, pp.250, 1239~1249
137. Weaver BA, "How Taxol", paclitaxel kills cancer cells, 2014, pp.25, 2677~2681
138. Wiedenfeld H, "Camptothecin and 10-hydroxycamptothecin in callus and plantlets of Camptotheca acuminata", Plant Cell, Tissue and Organ Culture, 49, pp.213~218 (1997)
139. Xu M, "WRKY transcription factor OpWRKY1 acts as a negative regulator of camptothecin biosynthesis in Ophiorrhiza pumila hairy roots", Plant Cell, Tissue and Organ Culture, 142, pp.69~78 (2020)
140. Yamazaki Y, "Camptothecin biosynthetic genes in hairy roots of Ophiorrhiza pumila : Cloning, characterization and differential expression in tissues and by stress compounds", Plant and Cell Physiology, 44, pp.395~403 (2003)
141. Yamazaki Y, "Metabolite profiling of alkaloids and strictosidine synthase activity in camptothecin producing plants", Phytochemistry, 62, pp.461~470 (2003)
142. Yan X, "Apigenin inhibits proliferation of human chondrosarcoma cells via cell cycle arrest and mitochondrial apoptosis induced by ROS generation-an in vitro and in vivo study", International Journal of Clinical and Experimental Medicine, 11, pp.1615~1631 (2018)
143. Yang DL, "Chilling temperature stimulates growth, gene over-expression and podophyllotoxin biosynthesis in Podophyllum hexandrum Royle", Plant Physiology and Biochemistry, 107, pp.197~203 (2016)
144. Yang M, "Divergent camptothecin biosynthetic pathway in Ophiorrhiza pumila", BMC Biology, 19, pp.122~ (2021)
145. Younessi-Hamzekhanlu M, "Exploitation of next generation sequencing technologies for unraveling metabolic pathways in medicinal plants : A concise review", Industrial Crops and Products, 178, pp.114669~ (2022)
146. Yousefzadi M, "Salicylic acid improves podophyllotoxin production in cell cultures of Linum album by increasing the expression of genes related with its biosynthesis", Biotechnology Letters, 32, pp.1739~1743 (2010)
147. Yousefzadi M, "The effect of light on gene expression and podophyllotoxin biosynthesis in Linum album cell culture", Plant Physiology and Biochemistry, 56, pp.41~46 (2012)
148. Zerbe P, "Plant diterpene synthases : Exploring modularity and metabolic diversity for bioengineering", Trends in Biotechnology, 33, pp.419~428 (2015)
149. Zhang J, "A microbial supply chain for production of the anti-cancer drug vinblastine", Nature, 609, pp.341~347 (2022)
150. Zhao J, "Manipulating indole alkaloid production by Catharanthus roseus cell cultures in bioreactors : From biochemical processing to metabolic engineering", Phytochemistry Reviews, 6, pp.435~457 (2007)
151. Zhu J, "Biosynthesis and regulation of terpenoid indole alkaloids in Catharanthus roseus", Pharmacognosy Reviews, 9, pp.24~28 (2015)
152. Zhu L, "Progress in research on paclitaxel and tumor immunotherapy", Cellular and Molecular Biology Letters, 24, pp.40~ (2019)

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