Radical Scavenging Active Compound Analysis in Extract of Coffee Silver Skin
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Background: Coffee silver skin is a by-product generated during the processing of coffee, which has recently been cultivated mainly in the southern regions of Korea. Radical scavenging active compounds were analyzed as part of a study of active compounds present in coffee silver skin. Methods and Results: Hot water extracts and ethanol extracts were prepared at varying concentra- tions (10% - 95%). Simultaneously with liquid chromatography (LC) separation, 1,1-diphenyl-2- picrylhydrazyl radical scavenging activity was measured and mass spectrometry (MS) of the iden- tified radical scavenging active compound peak was performed. The analysis results confirmed the presence of three compounds, eicosanoyl-5-hydroxytryptamide, docosanoyl-5-hydroxytryptamide, and tetracosanoyl-5-hydroxytryptamide. In the rapid LC-MS/MS analysis using the multiple reac- tion monitoring mode, each active compound showed a higher content as the ethanol concentration increased. In particular, the content of each compound was found to be significantly decreased in the extract with an ethanol concentration of 60% or less. Conclusions: The three identified alkanoyl-5-hydroxytryptamide compounds are reported to pos- sess antioxidant activity and various neurological disease-related effects. Therefore, this analysis method can be applied to research or product development using coffee silver skin
Abstract
Background: Coffee silver skin is a by-product generated during the processing of coffee, which has recently been cultivated mainly in the southern regions of Korea. Radical scavenging active compounds were analyzed as part of a study of active compounds present in coffee silver skin. Methods and Results: Hot water extracts and ethanol extracts were prepared at varying concentra- tions (10% - 95%). Simultaneously with liquid chromatography (LC) separation, 1,1-diphenyl-2- picrylhydrazyl radical scavenging activity was measured and mass spectrometry (MS) of the iden- tified radical scavenging active compound peak was performed. The analysis results confirmed the presence of three compounds, eicosanoyl-5-hydroxytryptamide, docosanoyl-5-hydroxytryptamide, and tetracosanoyl-5-hydroxytryptamide. In the rapid LC-MS/MS analysis using the multiple reac- tion monitoring mode, each active compound showed a higher content as the ethanol concentration increased. In particular, the content of each compound was found to be significantly decreased in the extract with an ethanol concentration of 60% or less. Conclusions: The three identified alkanoyl-5-hydroxytryptamide compounds are reported to pos- sess antioxidant activity and various neurological disease-related effects. Therefore, this analysis method can be applied to research or product development using coffee silver skin
참고문헌 (33)
- 안혜령, "커피 실버스킨을 첨가한 옐로우 레이어 케이크의 품질특성", Culinary Science & Hospitality Research, 19(3), pp.33~45 (2013), (사)한국조리학회[DOI]
- Asam K, "Eicosanoyl-5-hydroxytryptamide(EHT)prevents Alzheimer's disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid", PLOS ONE, 12, pp.e0189413~ (2017)
- Benayad Z, "Characterization of flavonoid glycosides from fenugreek(Trigonella foenum-graecum)crude seeds by HPLC-DAD-ESI", MS analysis, 2014, pp.15, 20668~20685
- Bessada SMF, "Coffee silverskin: A review on potential cosmetic applications", Cosmetics, 5, pp.5~ (2018)
- Blois MS, "Antioxidant determinations by the use of a stable free radical", Nature, 181, pp.1199~1200 (1958)
- Bouhafsoun A, "Simultaneous quantification of phenolic acids and flavonoids in Chamaerops humilis L. using LC-ESI-MS", MS, 2018, pp.38, 242~247
- Cao Y, "Chemical profile and multicomponent quantitative analysis for the quality evaluation of toad venom from different origins", Molecules, 24, pp.3595~ (2019)
- 차배천, "진피의 수치 조건에 따른 성분 및 항산화 활성 변화", 생약학회지, 46(1), pp.23~30 (2015), 한국생약학회
- El-Hawary EA, "How does LC", MS compare to UV in coffee authentication and determination of antioxidant effects? Brazilian and Middle Eastern coffee as case studies, 2022, pp.11, 131~
- Ghazvini AKA, "An investigation on the possible use of coffee silverskin in PLA", PBS composites, 2022, pp.139, 52264~
- Gottstein V, "Coffee silver skin: Chemical characterization with special consideration of dietary fiber and heat-induced contaminants", Foods, 10, pp.1705~ (2021)
- 홍재승, "실시간 활성시스템을 접목한 감초의 유효성분에 대한 표준화 연구", 한국자원식물학회지, 27(5), pp.401~414 (2014), 한국자원식물학회[DOI]
- 임도연, "유근피 추출물의 radical 소거 활성 성분에 대한 LC-MS", MS 스크리닝 분석법, 2020, pp.30(11), 956~964[DOI]
- 임도연, "HPLC와 DPPH radical 소거능 측정 방법의 결합에 의한 약용 식물 추출물의 항산화 활성 비교", 생명과학회지, 27(1), pp.44~49 (2017), 한국생명과학회
- 이준범, "지역마케팅을 위한 통합적 관점의 지역산업정책에 관한 연구", 비즈니스융복합연구, 6(3), pp.9~17 (2021), 한국비즈니스학회
- 김아영, "식물정유 10 종의 라디칼 소거 활성과 주요 활성 성분의 탐색", 한국약용작물학회지, 27(6), pp.427~435 (2019), 한국약용작물학회[DOI]
- 김학곤, "산초유 산패방지를 위한 항산화물질과 혼합유의 영향", 한국약용작물학회지, 26(6), pp.455~463 (2018), 한국약용작물학회[DOI]
- 김선민, "비파엽 열수 추출물에서 분리한 Caffeoylquinic Acid 3 종의 Nitric Oxide 생성 억제 효과", 한국약용작물학회지, 28(4), pp.245~253 (2020), 한국약용작물학회[DOI]
- "Food market news letter" (2022)[URL]
- Lang R, "Quantitation of βN-alkanoyl-5-hydroxy-tryptamides in coffee by means of LC-MS", MS-SIDA and assessment of their gastric acid secretion potential using the HGT-1 cell assay, 2009, pp.58, 1593~1602
- 이경은, "커피 은피 추출물의 항산화 효과와 엘라스타제, 콜라게나제 및 티로시나제 저해효과", 대한화장품학회지, 44(1), pp.39~48 (2018), 사단법인 대한화장품학회[DOI]
- 이경인, "Comparison of Major Compounds of Coffee Tree Leaf Extract by Varieties Cultivated in Korea", 한국약용작물학회지, 30(6), pp.401~410 (2022), 한국약용작물학회
- 이경인, "커피나무 잎 추출물의 라디칼 소거 활성 성분 탐색", 한국약용작물학회지, 30(4), pp.264~277 (2022), 한국약용작물학회
- Martuscelli M, "Characterization of coffee silver skin as potential food-safe ingredient", Foods, 10, pp.1367~ (2021)
- 문상윤, "한국 고흥산 커피의 gas chromatograph-ion mobility spectrometer에 의한 향기 특성 분석", Food Science and Preservation, 26(5), pp.576~585 (2019), 한국식품저장유통학회
- 나은식, "GC-MS", MS와 LC-MS, 한국환경농학회지, pp.2020, 39(2)[DOI]
- Narita Y, "Review on utilization and composition of coffee silverskin", Food Research International, 61, pp.16~22 (2014)
- Regazzoni L, "Coffee silver skin as a source of polyphenols : High resolution mass spectrometric profiling of components and antioxidant activity", Journal of Functional Foods, 20, pp.472~485 (2016)
- Run Y, "Synergistic neuroprotection by coffee components eicosanoyl-5- hydroxytryptamide and caffeine in models of Parkinson's disease and DLB", Proceedings of the National Academy of Sciences of the United States of America, 115, pp.E12053~E12062 (2018)
- 송종호, "생열귀나무 잎 추출물과 분획물의 항산화 및 NO생성 억제 활성", 한국약용작물학회지, 23(1), pp.20~26 (2015), 한국약용작물학회[DOI]
- Song Hua Xuan, "Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin", 생체재료학회지, 23(1), pp.64~74 (2019), 한국생체재료학회[DOI]
- 유남호, "Comparison of Anti-oxidant and Anti-inflammatory Activities of Methanolic Extracts Obtained from Different Parts of Cotoneaster wilsonii Nakai", 한국약용작물학회지, 27(3), pp.194~201 (2019), 한국약용작물학회[DOI]
- Zhang H, "An on-line HPLC-FRSD system for rapid evaluation of the total antioxidant capacity of Citrus fruits", Food Chemistry, 172, pp.622~629 (2015)