PEGylation of Silk Fibroin Model Peptide
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초록
Silk fibroin model peptide, alanine pentamer was synthesized through solid-phase method and modified with poly(ethylene glycol). Nuclear magnetic resonance spectrometry and Fourier-transform infrared spectroscopy showed the conformation of alanine pentamer,β-sheet structure and random coil conformation were not changed with PEGylation. Differential scanning calorimetry showed that relatively strong exothermic peak around 180oC by PEGylation. No cytotoxicity of PEGylated pentamer was observed by L929 cell proliferation test.
Abstract
Silk fibroin model peptide, alanine pentamer was synthesized through solid-phase method and modified with poly(ethylene glycol). Nuclear magnetic resonance spectrometry and Fourier-transform infrared spectroscopy showed the conformation of alanine pentamer,β-sheet structure and random coil conformation were not changed with PEGylation. Differential scanning calorimetry showed that relatively strong exothermic peak around 180oC by PEGylation. No cytotoxicity of PEGylated pentamer was observed by L929 cell proliferation test.
참고문헌 (34)
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