임플란트 식립 환자의 PostPlant(TM) Calcium 투여 효과에 대한 임상연구
The efficacy evaluation of PostPlant(TM) Calcium in dental implant placement
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연구목적: 본 연구에서는 건강기능식품인 PostPlant(TM) Calcium을 임플란트 식립 환자에게 투여하고, 투여하지 않은 군과 비교하여 그 유효성과 안정성을 평가하여 투여 후 골밀도의 변화 및 골유착 기간의 단축 여부를 평가하고자 하였다. 연구 재료 및 방법: 임플란트 식립 후에 PostPlant(TM) Calcium을 투여한 실험군은 18명의 환자를 대상으로 25개의 임플란트를 식립하였고, 투여하지 않은 대조군에서는 7명의 환자에게 9개의 임플란트를 식립하여 관찰하였다. 일차수술 후, 이차수술 후, 6개월 후에 Osstell(TM) Mentor, Periotest(R)를 이용하여 임플란트 안정성을 비교 분석하였고, 일차수술 후, 1, 3, 6개월 후에 방사선 사진 촬영을 시행하여 임플란트 주위 골밀도를 측정하여 비교 분석하였다. 결과: 1. Osstell(TM) Mentor의해 측정된 ISQ 값은 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 수치가 높아지는 경향을 보였다. 실험군의 측정값이 대조군에 비해 더 높은 수치를 보였으며, 식립 6개월 후에 실험군과 대조군 간에 통계적으로 유의한 차이가 관찰되었다 (P< .05). 2. Periotest(R) 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 수치가 낮아지는 경향을 보였으며, 실험군이 대조군에 비해 더 낮은 수치를 나타내었으나 각 군간에 통계적인 유의성은 없었다. 3. 골밀도 측정 결과 시간이 경과함에 따라 실험군, 대조군 모두 골밀도 수치가 증가하는 경향을 보였으며, 실험군이 대조군에 비해 더 높은 수치를 나타내었으나 각 군간에 통계적인 유의성은 없었다. 결론: 임상적으로 임플란트 식립 후 환자가 PostPlant(TM) Calcium을 장기간 복용하는 것이 임플란트 안정성을 높이고, 골유착을 성공적으로 이루는데 도움을 줄 수 있다고 사료된다.
Abstract
Purpose: The aim of this study was to evaluate the changes in bone density and reduction of time consumed for osteogenesis by PostPlant(TM) Calcium and to find out efficacy of PostPlant(TM) Calcium by comparing the group prescribed with PostPlant(TM) Calcium with the group without PostPlant(TM) Calcium prescription. Material and methods: The experimental group of 18 patients with 25 dental implant placement and the control group of 7 patients with 9 dental implant placement were randomly selected from the patients who visited prosthetic department of Dankook University Dental Hospital since July, 2006 (IRB Number : 20060710). The experimental group was instructed to take PostPlant(TM) Calcium for 6 months after the implant surgery while the control group was instructed not to. Both experimental and control group were assigned for measurement using Osstell(TM) Mentor and Periotest(R). and radiographic examination was performed using specifically manufactured Aluminum Step Wedge. The results were compared and analyzed. Results: 1. According to the OsstellTM Mentor measurement, both the experimental and control group showed increase in values as time elapses and the experimental group showed significantly higher rate of increase (P < .05). 2. According to the Periotest(R). measurement, both the experimental and control group showed decrease in values as time elapses. In addition, greater decrease can be seen in the experimental group but no statistical significance was found. 3. By examining the radiographic images, both the experimental and control group showed tendency of increase in bone density. In addition, greater increase can be seen in the experimental group but no statistical significance was found. Conclusion: Clinically, taking PostPlant(TM) Calcium medicine for a long period of time after implant placement is expected for a better prognosis.
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