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과민성 장증후군 환자에서 베타 아드레날린 수용체 기능의 활성도와 불안 수준

Beta-adrenergic Receptor Function and Anxiety in Patients with Irritable Bowel Syndrome

이종철|이준행|유범희|강은호|김현서|이풍렬
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.01|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제1호|pp. 40-45

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참고문헌

키워드

과민성 장증후군 · 베타 아드레날린 수용체 · 불안.Irritable bowel syndrome · Beta-adrenergic receptor · Anxiety.
주제분류정신과학

초록

Abstract

Objectives：Recently, irritable bowel syndrome (IBS) is known to be related with neurotransmitters. This study was designed to determine β-adrenergic receptor function in patients with IBS and to compared with normal controls to examine the relationship between β-adrenergic receptor function and anxiety in IBS patients. Methods：Eighteen IBS patients were compared with the same number of age and sex-matched normal subjects in terms of β-adrenergic receptor function and psychological variables reflecting anxiety levels. To assess β-adrenergic receptor function, Chronotropic 25 dose (CD25) was calculated via isoproterenol stimulation test. Results：CD25 values in the patient group were significantly lower than those in the control group, which reflected increased β-adrenergic receptor function (2.19±1.08 versus 3.89±1.64, p<0.05). Patients with IBS showed higher HAM-A scores (8.88±4.88 versus 3.59±2.65, p<0.01), HAM-D scores (6.41±4.02 versus 2.47±2.40, p<0.01), BDI scores (9.00±6.21 versus 4.72±4.30, p<0.05), and STAI scores (STAI-S：43.41±6.34 versus 33.83±8.18, p<0.01, STAI-T：44.65±7.43 versus 38.17±8.45, p<0.05). In addition, HAM-A scores were negatively correlated with CD25 values in the patient group (r=-0.424, p<0.01). Conclusion：These results suggest that β-adrenergic receptor function is increased in patients with IBS, which could affect increased anxiety levels in these patients. (J Korean Neuropsychiatr Assoc 2004;43(1):40-45)

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