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일 대학병원에서 양극성장애 환자의 흡연 특성 : 정신분열병 환자와의 비교 연구

Smoking Characteristics in Bipolar Disorder : A Comparison Study with Schizophrenia

김지혜|김현진|조현상|천덕희|이강수
대한신경정신의학회 (Korean Neuropsychiatric Association)|2006.07|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제45권 제4호|pp. 330-336

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참고문헌

키워드

양극성 장애·정신분열병·흡연.Bipolar disorder· Smoking· Schizophrenia.
주제분류정신과학

초록

본 연구는 정신분열병 환자들과의 비교를 통해 양극성 장 애 환자들의 흡연율 및 흡연특성을 알아보고자 한 것이었 다. 국내에서는 양극성 장애의 흡연 연구가 전무한 상황이 라는 점에서 본 연구는 그 의의를 가질 수 있다. 그 결과 양극성 장애의 흡연율과 전반적인 흡연심각도는 정신분열 병과 비교하여 유의한 차이가 없었다. 그러나 양극성 장애 환자들이 정신분열병 환자에 비해 일일 흡연량이 유의하 게 적었으며, 여성 양극성 장애 환자가 여성 정신분열병에 비해 흡연율이 더 높았다. 양극성 장애군에서 정신분열병 과 유사한 높은 흡연율 및 흡연 심각도를 보이는 것은 양 극성 장애가 정신분열병과 마찬가지로 니코틴성 콜린계의 기능이상과 관련될 수 있음을 시사한다.

Abstract

Objectives：This study aimed to investigate smoking characteristics and nicotine dependence severity in bipolar disorder comparing those of schizophrenia. Methods：70 bipolar and 123 schizophrenic patients, diagnosed using DSM-IV-TR criteria and treated at the Severance Mental Health Hospital, were interviewed regarding socio-demographic variables, smoking characteristics and Fagerstrom Test for Nicotine Dependence (FTND), designed to evaluate the intensity of smoking. Results：The rate of current smoking was 60.0% in the bipolar group, and 50.4% in the schizophrenia group. No significant difference was seen in terms of the rate of current smoking between the groups. Rates of having ever smoked also did not differ between bipolar (73%) and schizophrenic patients (65%). Daily cigarette consumption of bipolar patients (15.9 cigarettes/day) was significantly lower than that of schizophrenic patients (21.2 cigarettes/day), but FTND score didn’t appear to differ between bipolar and schizophrenic patients. Bipolar females showed higher rate of current smoking (44%) than schizophrenic females (17%). Among bipolar patients, antipsychotics dose was not correlated with daily cigarette consumption and FTND total score. Age of disease onset didn’t appear to differ between smokers and non-smokers in bipolar group. Conclusion：Although daily consumption was significantly lower in the bipolar group, the rate of smoking and smoking severity in bipolar disorder were as high as in schizophrenia. This fact suggests that the bipolar disorder might be related to the nicotinic acetylcholine system dysfunction as like schizophrenia. (J Korean Neuropsychiatr Assoc 2006;45(4):330-336)

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