한국인 조현병 환자에서 흡연과 사회인구학적, 임상적 특성과의 관계
Relationships between Cigarette Smoking and Socio-Demographic and Clinical Characteristics in Patients with Schizophrenia in South Korea
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초록
본 연구는 한국 조현병 환자들을 대상으로 흡연과 임상적,인구사회학적 특성의 연관성을 알아보고자 하였다. 그 결과흡연을 하는 조현병 환자들에서 직업을 가진 경우가 많았고,편집성 아형인 경우가 많았으며, 혈압도 높은 것으로 조사되었다. 또한 인지장애증상과 음성 증상도 비흡연자보다 덜 나타나는 것도 알 수 있었다. 하지만 약물처방패턴과 BMI, 양성증상과 우울증상, 사회적 기능 및 약물 부작용 등은 유의한 차이가 없었다. 조현병에서의 흡연율은 나라 및 문화권에 따라 차이가 있고, 특히 국내에서의 기존 연구가 많지 않은 상황이라는 점에서 특히 본 연구는 의의가 있다. 이 연구 결과를 바탕으로 하여, 향후에는 흡연량과 조현병 증상 및 약물 부작용의 관련성을 더 상세히 알아볼 수 있는 전향적 연구가 필요하다. 또한 조사시점에서 복용 중인 항정신병약물 별로 흡연이 어떠한 영향을 끼치는지, 니코틴이 조현병에 작용하는 기전이 무엇인지에 대해 더 알아보는 연구도 필요하겠다.
Abstract
Objectives In patients with schizophrenia, the prevalence of smoking is significantly higher than that of the general population. This study aimed to evaluate the relationships between cigarette smoking and socio-demographic and clinical characteristics in patients with schizophrenia in South Korea. Methods Post analysis of 2008-2009 three multi-center studies on the paliperidone extended-release switching was performed. A total of 509 patients with a diagnosis of schizophrenia were recruited and interviewed regarding socio-demographic variables, smoking characteristics. Krawiecka Scale, Clinical Global Impression-Schizophrenia-Severity, Clinical Global Impression-Schizophrenia-Improvement, and Personal and Social Performance Scale were used to evaluate psychological disturbance. Safety assessments included adverse events, evaluation of extrapyramidal symptoms using the Drug Induced Extra Pyramidal Symptoms Scale, and laboratory tests.Results The results revealed that the prevalence of smoking in Korean patients with schizophrenia is significantly higher than that of the general population. Male, patients with occupation,and paranoid type showed higher rate of smoking and smokers with schizophrenia had higher rates of overweight, thick waist, high blood pressure than non-smokers with schizophrenia. The results revealed that smokers with schizophrenia had higher rating scales of negative and cognitive symptoms. Conclusion From this study, we reported significant relationships between cigarette smoking and socio-demographic and clinical characteristics in patients with schizophrenia in South Korea. More studies will be needed to evaluate the association between cigarette consumption and schizophrenia, effect of smoking according to the antipsychotics, mechanism of nicotine on schizophrenia.
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