뚜렛 장애 남아에서 틱 억제시 대뇌 피질 정보 전달
Cortical Information Transmisson during Tic Suppression in Boys with Tourette's Disorder
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초록
본 연구는 뚜렛 장애 아동에서 뇌파의 비선형 분석을 이용하여 틱 억제시 대뇌피질 정보전달을 살펴본 첫 연구이 다. 뚜렛장애의 병리에는 피질 하 구조 뿐 아니라 광범위한 피질간의 정보전달 또한 중요한 역할을 하며 틱 억제 시에는 전두엽에서의 정보 전달이 관여함을 시사한다. 또한 엔트로피 전달을 이용한 뇌파의 비선형 분석은 피질 기 능을 연구하는데 유용한 도구가 될 수 있음을 시사한다.
Abstract
Objectives：Tourette’s Disorder (TD) is a chronic neuropsychiatric disorder characterized by multiple motor and vocal tics with onset in childhood. The aim of this study was to ascertain the increased cortical information transmission in frontal area during tic suppression in drug naive boys with TD using new nonlinear analysis of EEGs, be called Transfer Entropy (TE) which can detect the directed exchange of information between two systems. Methods：Subjects were 11 drug naive boys with DSM-IV diagnosis of TD and 10 control boys. Clinical assessments were performed, and EEGs were recorded from 19 scalp loci of the international 10-20 systems. TE was estimated by EEG timeseries data after noise reduction. TE difference between TD and control during resting state and between tic suppression and resting state in TD were investigated. Results：Elevated TE was found in extensive channels, including frontal, central and temporal channels (F7, Fz, F8,Cz, C3, P3, T3, and T4) in resting state of Tourette’s disorder compared to normal controls. During tic suppression elevated TE was found in more extensive and asymmetrical channels especially prefrontal area (Fp1, Fp2, F3, Fz, F7, F8, Cz, C4, C5, T3, and T4). Conclusion：These findings suggest that pathogenesis of Tourette’s disorder involve impaired cortical neuronal modulation in subcortical neural circuits. EEG analysis of TE may be a useful tool to investigation of cortical mechanism of psychiatric illness. (J Korean Neuropsychiatr Assoc 2007;46(1):71-78)
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