기억상실성 경도인지장애 환자의 신경정신 증상
Neuropsychiatric Symptoms in Patients with Amnestic Mild Cognitive Impairment
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초록
본 연구 결과, 경도 AD 환자에 비해 aMCI 환자가 경험 하는 이상 행동 증상의 빈도는 유의미하게 적은 것으로 나 타났다. 하지만 aMCI 환자의 상당수가 이미 다양한 행동 문제를 보였고, 경도 AD 환자에서 보이는 행동 증상과 유 사한 양상이었다. 이는 AD로 발전할 가능성이 높은 MCI 의 하위 집단을 확인하기 위하여 MCI 환자의 신경정신 증 상을 평가함으로써 보다 초기에 병을 진단하고 치료적으로 개입하는데 도움이 될 수 있음을 의미한다.
Abstract
Objectives To define the neuropsychiatric features of amnestic-type Mild Cognitive Impairment (aMCI) and compare them with those of mild Alzheimer’s disease (AD). Methods The study participants included 353 aMCI and 500 mild AD patients. The Neuropsychiatric Inventory (NPI) was used to assess the neuropsychiatric symptoms in two groups. Results 65.4% of aMCI and 85.4% of mild AD patients exhibited neuropsychiatric symptoms. The most common symptoms in the aMCI group were depression (33.7%), irritability (29.5%), sleep/ night-time behavior (23.2%), apathy (21.5%), and anxiety (21.2). The most common features in the mild AD group were depression (52.4%), apathy (52%), irritability (41.6%), and anxiety (41%). There were significant differences between the aMCI and mild AD groups in 11 NPI symptoms except sleep/night-time behavior. Conclusion A high prevalence of neuropsychiatric symptoms were associated with aMCI, especially mood disturbances and apathy. In contrast, psychotic symptoms were rare. The neuropsychiatric symptoms observed in aMCI were similar to those of mild AD.
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