난독증 아동의 뇌백질 연결성 변화 : 환자-대조군 연구
Alteration of White Matter Integrity in Dyslexic Children : Case-Control Study
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Objectives To compare the white matter microstructure of dyslexic children with normal children using diffusion tensor imaging. Methods Twenty one dyslexic children and 24 normal control children were recruited in the second and third grade of elementary school students. The fractional anisotropy (FA) values of 20 representative white matter tracts were estimated from the diffusion tensor imaging data of each subject using the Johns Hopkins University–white matter tractography atlas to determine the difference in white matter integrity between the dyslexic children and normal children. Results Compared to the normal control group, the FA values of the left inferior longitudinal fasciculus [F(1,39)=5.908, p<0.05] and temporal part of the right superior longitudinal fasciculus [F(1,39)=7.328, p=0.010] were significantly higher in the dyslexic group and there was no significant difference in the other tracts. Conclusion In dyslexic children, compensatory pathways develop in the left inferior longitudinal fasciculus and in the temporal part of the right superior longitudinal fasciculus.
Abstract
Objectives To compare the white matter microstructure of dyslexic children with normal children using diffusion tensor imaging. Methods Twenty one dyslexic children and 24 normal control children were recruited in the second and third grade of elementary school students. The fractional anisotropy (FA) values of 20 representative white matter tracts were estimated from the diffusion tensor imaging data of each subject using the Johns Hopkins University–white matter tractography atlas to determine the difference in white matter integrity between the dyslexic children and normal children. Results Compared to the normal control group, the FA values of the left inferior longitudinal fasciculus [F(1,39)=5.908, p<0.05] and temporal part of the right superior longitudinal fasciculus [F(1,39)=7.328, p=0.010] were significantly higher in the dyslexic group and there was no significant difference in the other tracts. Conclusion In dyslexic children, compensatory pathways develop in the left inferior longitudinal fasciculus and in the temporal part of the right superior longitudinal fasciculus.
참고문헌 (31)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental disorders(DSM-5®)" (2013), APA Publishing
- Shaywitz SE, "Dyslexia", N Engl J Med, 338, pp.307~312 (1998)
- Shaywitz SE, "Dyslexia(specific reading disability)", Biol Psychiatry, 57, pp.1301~1309 (2005)
- 김윤옥, "난독증 선별 체크리스트 개발 연구", 학습장애연구, 11(2), pp.99~128 (2014), 한국학습장애학회
- Lyon GR, "A definition of dyslexia", Ann Dyslexia, 53, pp.1~14 (2003)
- Norton ES, "Neurobiology of dyslexia", Curr Opin Neurobiol, 30, pp.73~78 (2015)
- Shaywitz SE, "Paying attention to reading : the neurobiology of reading and dyslexia", Dev Psychopathol, 20, pp.1329~1349 (2008)
- Hoeft F, "Neural systems predicting long-term outcome in dyslexia", Proc Natl Acad Sci U S A, 108, pp.361~366 (2011)
- Shaywitz BA, "Disruption of posterior brain systems for reading in children with developmental dyslexia", Biol Psychiatry, 52, pp.101~110 (2002)
- Glasser MF, "DTI tractography of the human brain’s language pathways", Cereb Cortex, 18, pp.2471~2482 (2008)
- Caylak E, "Neurobiological approaches on brains of children with dyslexia : review", Acad Radiol, 16, pp.1003~1024 (2009)
- Kim A, "Test of Reading Achievement and Reading Cognitive Processes Ability(RA-RCP)" (2014), Hakjisa
- 김애화, "학습장애, 난독증, 학습부진(경계선 지능 포함) 및 학습지원대상 학생은 누구이며, 교육적 지원은 이대로 괜찮은가?: 특수교육의 역할과 과제에 대한 소고", 특수교육학연구, 53(1), pp.1~21 (2018), 한국특수교육학회[DOI]
- Korean Educational Development Institute-Wechsler Intelligence scale for children(KEDI-WISC), "Park K", Korean Educational Development Institute, ~ (2002)
- Development of KEDIWISC, individual intelligence test for Korean children, "Park K", Korean Educational Development Institute, ~ (1986)
- Grant DA, "A behavioral analysis of degree of reinforcement and ease of shifting to new responses in a Weigl-type card-sorting problem", J Exp Psychol, 38, pp.404~411 (1948)
- Heaton RK, "Wisconsin card sorting test manual", Psychological Assessment Resources, 5~57 (1981)
- 유한익, "국내 아동 및 청소년 주의력 평가를 위한 종합주의력검사의 표준화 연구", Journal of the Korean Academy of Child and Adolescent Psychiatry, 20(2), pp.68~75 (2009), 대한소아청소년 정신의학회
- Mori S, "MRI atlas of human white matter", Am J NeuroRadiol, 27, pp.1384~1385 (2005)
- Mori S, "MRI atlas of human white matter" (2005), Elsevier Science
- "JHU ICBM tracts maxprob thr25 1mm" (2016)[URL]
- Gorgolewski KJ, "NeuroVault.org: a web-based repository for collecting and sharing unthresholded statistical maps of the human brain", Front Neuroinform, 9, pp.8~ (2015)
- Herbet G, "Functional anatomy of the inferior longitudinal fasciculus : from historical reports to current hypotheses", Front Neuroanat, 12, pp.77~ (2018)
- Schlaffke L, "Learning Morse code alters microstructural properties in the inferior longitudinal fasciculus : a DTI study", Front Hum Neurosci, 11, pp.383~ (2017)
- Mandonnet E, "Does the left inferior longitudinal fasciculus play a role in language? A brain stimulation study", Brain, 130, pp.623~629 (2007)
- Madhavan KM, "Superior longitudinal fasciculus and language functioning in healthy aging", Brain Res, 1562, pp.11~22 (2014)
- Urger SE, "The superior longitudinal fasciculus in typically developing children and adolescents : diffusion tensor imaging and neuropsychological correlates", J Child Neurol, 30, pp.9~20 (2015)
- Klarborg B, "Sustained attention is associated with right superior longitudinal fasciculus and superior parietal white matter microstructure in children", Hum Brain Mapp, 34, pp.3216~3232 (2013)
- Wolfers T, "Lower white matter microstructure in the superior longitudinal fasciculus is associated with increased response time variability in adults with attention-deficit", hyperactivity disorder, 2015, pp.40, 344~351
- Žarić G, "Atypical white matter connectivity in dyslexic readers of a fairly transparent orthography", Front Psychol, 9, pp.1147~ (2018)
- Shaywitz SE, "Evidence that dyslexia may represent the lower tail of a normal distribution of reading ability", N Engl J Med, 326, pp.145~150 (1992)