본문 바로가기
KERD
논문KCI 등재

알레르기비염의 치료에 있어서의 설하면역요법의 역할

Sublingual immunotherapy for allergic rhinitis

2

조회

0

다운로드

1

인용

0

참고문헌

키워드

주제분류소아과학

초록

Allergen specific immunotherapy is a medical treatment aiming at patients suffering from allergies that are insufficiently controlled by symptomatic treatments. Allergen immunotherapy rehabilitates the immune system. Subcutaneous immunotherapy (SCIT) is the historical route of administration and consists of allergen extract injections. SCIT has proven efficacy in allergic rhinitis and asthma, but it requires regular injections at the hospital and carries the risk of potentially serious systemic allergic reactions in response to the treatment itself. Sublingual immunotherapy (SLIT) offers several specific advantages over SCIT. SLIT is more easily administered, avoids cumbersome injections regimens, and carries a much lower risk of anaphylactic shock compared with SCIT. So, this article will discuss the mechanisms of action, advantages, and limitations of SLIT for allergic rhinitis.

Abstract

Allergen specific immunotherapy is a medical treatment aiming at patients suffering from allergies that are insufficiently controlled by symptomatic treatments. Allergen immunotherapy rehabilitates the immune system. Subcutaneous immunotherapy (SCIT) is the historical route of administration and consists of allergen extract injections. SCIT has proven efficacy in allergic rhinitis and asthma, but it requires regular injections at the hospital and carries the risk of potentially serious systemic allergic reactions in response to the treatment itself. Sublingual immunotherapy (SLIT) offers several specific advantages over SCIT. SLIT is more easily administered, avoids cumbersome injections regimens, and carries a much lower risk of anaphylactic shock compared with SCIT. So, this article will discuss the mechanisms of action, advantages, and limitations of SLIT for allergic rhinitis.

참고문헌 (44)

  1. Togias A, "Rhinitis and asthma: evidence for respiratory system integration", J Allergy Clin Immunol, 111, pp.1171~1183 (2003)
  2. Sur DK, "Treatment of allergic rhinitis", Am Fam Physician, 81, pp.1440~1446 (2010)
  3. Noon L, "Prophylactic inoculation against hay fever", Lancet, 177, pp.1572~1573 (1911)
  4. Cohen SG, "Allergen immunotherapy in historical perspective", Clin Allergy Immunol, 18, pp.1~36 (2004)
  5. Joint Task Force on Practice Parameters, "Allergen immunotherapy: a practice parameter second update", J Allergy Clin Immunol, 120(3), pp.S25~S85 (2007)
  6. Scadding GK, "BSACI guidelines for the management of allergic and non-allergic rhinitis", Clin Exp Allergy, 38, pp.19~42 (2008)
  7. Canonica GW, "Sub-lingual immunotherapy: world allergy organization position paper 2009", Allergy, 64(91), pp.1~59 (2009)
  8. Moingeon P, "Immune mechanisms of allergen-specific sublingual immunotherapy", Allergy, 61, pp.151~165 (2006)
  9. La Rosa M, "Double-blind placebo-controlled evaluation of sublingual-swallow immunotherapy with standardized Parietaria judaica extract in children with allergic rhinoconjunctivitis", J Allergy Clin Immunol, 104(2 Pt 1), pp.425~432 (1999)
  10. Lima MT, "Grass pollen sublingual immunotherapy for seasonal rhinoconjunctivitis: a randomized controlled trial", Clin Exp Allergy, 32, pp.507~514 (2002)
  11. Tari MG, "Efficacy of sublingual immunotherapy in patients with rhinitis and asthma due to house dust mite: a double-blind study", Allergol Immunopathol (Madr), 18, pp.277~284 (1990)
  12. Smith H, "Randomized controlled trial of high-dose sublingual immunotherapy to treat seasonal allergic rhinitis", J Allergy Clin Immunol, 114, pp.831~837 (2004)
  13. Radulovic S, "Systematic reviews of sublingual immunotherapy (SLIT)", Allergy, 66, pp.740~752 (2011)
  14. Wilson DR, "Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis", Allergy, 60, pp.4~12 (2005)
  15. Scadding G, "Mechanisms of sublingual immunotherapy", Immunol Allergy Clin North Am, 31, pp.191~209 (2011)
  16. Pajno GB, "Clinical and immunologic effects of long-term sublingual immunotherapy in asthmatic children sensitized to mites: a double-blind, placebo-controlled study", Allergy, 55, pp.842~849 (2000)
  17. Kim ST, "Clinical and immunologic effects of sublingual immunotherapy on patients with allergic rhinitis to house-dust mites: 1-year follow-up results", Am J Rhinol Allergy, 24, pp.271~275 (2010)
  18. Malling HJ, "Safety and immunological changes during sublingual immunotherapy with standardized quality grass allergen tablets", J Investig Allergol Clin Immunol, 16, pp.162~168 (2006)
  19. Bahceciler NN, "Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites", Int Arch Allergy Immunol, 136, pp.287~294 (2005)
  20. Ciprandi G, "Sublingual immunotherapy induces spirometric improvement associated with IL-10 production: preliminary reports", Int Immunopharmacol, 6, pp.1370~1373 (2006)
  21. Marcucci F, "Sublingual tryptase and ECP in children treated with grass pollen sublingual immunotherapy (SLIT): safety and immunologic implications", Allergy, 56, pp.1091~1095 (2001)
  22. Passalacqua G, "Global Allergy and Asthma European Network. Allergic rhinitis and its impact on asthma update: allergen immunotherapy", J Allergy Clin Immunol, 119, pp.881~891 (2007)
  23. Akdis M, "Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells", J Exp Med, 199, pp.1567~1575 (2004)
  24. Akdis CA, "Role of interleukin 10 in specific immunotherapy", J Clin Invest, 102, pp.98~106 (1998)
  25. Jutel M, "IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy", Eur J Immunol, 33, pp.1205~1214 (2003)
  26. Arikan C, "Bacillus Calmette-Guérin-induced interleukin-12 did not additionally improve clinical and immunologic parameters in asthmatic children treated with sublingual immunotherapy", Clin Exp Allergy, 34, pp.398~405 (2004)
  27. Bousquet J, "Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen)", Allergy, 63(86), pp.8~160 (2008)
  28. Wuthrich B, "Double-blind, placebo-controlled study with sublingual immunotherapy in children with seasonal allergic rhinitis to grass pollen", J Investig Allergol Clin Immunol, 13, pp.145~148 (2003)
  29. Olaguibel JM, "Efficacy of sublingual allergen vaccination for respiratory allergy in children. Conclusions from one meta-analysis", J Investig Allergol Clin Immunol, 15, pp.9~16 (2005)
  30. Penagos M, "Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age", Chest, 133, pp.599~609 (2008)
  31. Di Bona D, "Efficacy of sublingual immunotherapy with grass allergens for seasonal allergic rhinitis: a systematic review and meta-analysis", J Allergy Clin Immunol, 126, pp.558~566 (2010)
  32. Bufe A, "Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study", Allergy, 59, pp.498~504 (2004)
  33. Guez S, "House-dust-mite sublingual-swallow immunotherapy (SLIT) in perennial rhinitis: a double-blind, placebo-controlled study", Allergy, 55, pp.369~375 (2000)
  34. Durham SR, "Sublingual immunotherapy with once-daily grass allergen tablets: a randomized controlled trial in seasonal allergic rhinoconjunctivitis", J Allergy Clin Immunol, 117, pp.802~809 (2006)
  35. Novembre E, "Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis", J Allergy Clin Immunol, 114, pp.851~857 (2004)
  36. Marogna M, "Preventive effects of sublingual immunotherapy in childhood: an open randomized controlled study", Ann Allergy Asthma Immunol, 101, pp.206~211 (2008)
  37. Winther L, "Allergen-specific immunotherapy in birch- and grass-pollen-allergic rhinitis. II. Side-effects", Allergy, 55, pp.827~835 (2000)
  38. Moreno C, "Immunotherapy Committee, Sociedad Espanola de Alergologia e Inmunologia Clinica. Immunotherapy safety: a prospective multi-centric monitoring study of biologically standardized therapeutic vaccines for allergic diseases", Clin Exp Allergy, 34, pp.527~531 (2004)
  39. Kleine-Tebbe J, "Safety of a SQ-standardised grass allergen tablet for sublingual immunotherapy: a randomized, placebo-controlled trial", Allergy, 61, pp.181~184 (2006)
  40. Casale TB, "Recommendations for appropriate sublingual immunotherapy clinical trials", J Allergy Clin Immunol, 124, pp.665~670 (2009)
  41. Cox LS, "Sublingual immunotherapy: a comprehensive review", J Allergy Clin Immunol, 117, pp.1021~1035 (2006)
  42. Bousquet J, "Allergen immunotherapy: therapeutic vaccines for allergic diseases. A WHO position paper", J Allergy Clin Immunol, 102(4 Pt 1), pp.558~562 (1998)
  43. Tahamiler R, "Long-term efficacy of sublingual immunotherapy in patients with perennial rhinitis", Laryngoscope, 117, pp.965~969 (2007)
  44. Marogna M, "Long-lasting effects of sublingual immunotherapy according to its duration: a 15-year prospective study", J Allergy Clin Immunol, 126, pp.969~975 (2010)

관련 논문AI추천

대한천식알레르기학회 설하면역요법 진료지침강성윤, 고영일, 김경훈, 김선태, 김주희, 남동호, 류광희, 민진영, 박경희, 박소영, 박중원, 성명순, 신유섭, 심정연, 안영민, 양은애, 이상민, 이영수, 이용원, 이화영, 정은희, 지혜미, 최선희, 최정희, 하은교, 한두희, 한만용, 대한천식알레르기학회 면역요법/알레르겐연구팀대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2024 · 제12권 제3호알레르기비염에서 알레르겐 특이 면역요법박중원대한내과학회 · 대한내과학회지2013 · 제84권 제6호Sublingual Immunotherapy in Allergic Rhinitis: Efficacy, Safety, Adherence and GuidelinesKarim Mohamed Elghanam, Omar Ali Aboshady대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2014 · 제7권 제4호통년성 알레르기 비염에서 피하 및 설하 면역 요법의 일대일 비교: 체계적인 고찰 및 메타 분석김효빈, 박도양, 심진아, 정수지, 최정희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2024 · 제12권 제1호집먼지진드기로 유발되는 알레르기비염에서 피하면역요법과 설하면역요법의 비교이상민대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2024 · 제12권 제1호알레르기성 호흡기 질환에서의 항원특이면역요법강성윤, 양민석, 이상민, 이상표대한내과학회 · 대한내과학회지2020 · 제95권 제6호

이 간행물의 다른 논문 (12건)