첩포시험을 이용한 유전자 변형 들잔디의 접촉피부염 인체위해성 검정
Biohazard surveillance of allergic contact dermatitis in genetically-modified Zoysia grasses using patch testing
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Purpose: Genetic modification technique is widely used in plants for improving crop yields and qualities, and reducing pesticide use. Zoysia japonica is one of the widely planted grasses for lawning. Pollenless herbicide-tolerant genetically modified (GM) grasses (JG21-MS1 and JG21-MS2) were developed under surveillance for possible biohazard. Grasses may cause allergic contact dermatitis with direct contact on human skin. Patch testing with allergens was adopted to compare the incidences of allergic contact dermatitis to GM grass leaves with those of wild-type grass. Methods: Patch testing with controls and leaves of wild-type and GM grasses was performed in individuals with informed consent. Results: Ninety-seven individuals (mean age, 32±8 years; 48% males) were enrolled. For nickel sulfate as a positive control, 38 subjects (39.2%) were positive. For GM grasses, 10 (10.3%) showed positive patch test results and 11 (11.3%), for wild-type grass, the proportions of which were similar among the tested grasses. Conclusion: JG21-MS1 and JG21-MS2 are not more biohazardous than wild-type grass in the risk of allergic contact dermatitis.
Abstract
Purpose: Genetic modification technique is widely used in plants for improving crop yields and qualities, and reducing pesticide use. Zoysia japonica is one of the widely planted grasses for lawning. Pollenless herbicide-tolerant genetically modified (GM) grasses (JG21-MS1 and JG21-MS2) were developed under surveillance for possible biohazard. Grasses may cause allergic contact dermatitis with direct contact on human skin. Patch testing with allergens was adopted to compare the incidences of allergic contact dermatitis to GM grass leaves with those of wild-type grass. Methods: Patch testing with controls and leaves of wild-type and GM grasses was performed in individuals with informed consent. Results: Ninety-seven individuals (mean age, 32±8 years; 48% males) were enrolled. For nickel sulfate as a positive control, 38 subjects (39.2%) were positive. For GM grasses, 10 (10.3%) showed positive patch test results and 11 (11.3%), for wild-type grass, the proportions of which were similar among the tested grasses. Conclusion: JG21-MS1 and JG21-MS2 are not more biohazardous than wild-type grass in the risk of allergic contact dermatitis.
참고문헌 (21)
- Rajan TV, "The Gell-Coombs classification of hypersensitivity reactions : a re-interpretation", Trends Immunol, 24, pp.376~379 (2003)
- Mortz CG, "Allergic contact dermatitis in children and adolescents", Contact Dermatitis, 41, pp.121~130 (1999)
- 전봉희, "제주 소아 및 청소년의 아토피 및 흡입 알레르기항원에 대한 감작률", 천식 및 알레르기, 30(1), pp.14~20 (2010), 대한천식알레르기학회
- Koh D, "Allergic contact dermatitis from grasses", Contact Dermatitis, 37, pp.32~34 (1997)
- Clark RA, "Aeroallergen contact can exacerbate atopic dermatitis:patch tests as a diagnostic tool", J Am Acad Dermatol, 21(4 Pt 2), pp.863~869 (1989)
- Ganesan M, "Overexpression of phytochrome A and its hyperactive mutant improves shade tolerance and turf quality in creeping bentgrass and zoysiagrass", Planta, 236, pp.1135~1150 (2012)
- 이효연, "Production of Herbicide-tolerant Zoysiagrass by Agrobacterium-mediated Transformation", Molecules and Cells, 16(1), pp.19~27 (2003), 한국분자세포생물학회
- Bae TW, "Environmental risk assessment of genetically engineered herbicide-tolerant Zoysia japonica", J Environ Qual, 37, pp.207~218 (2008)
- Bae TW, "Selection of male-sterile and dwarfism genetically modified Zoysia japonica through gamma irradiation", J Radiati Ind, 4, pp.239~246 (2010)
- Bae TW, "Production of unbolting lines through gamma-ray irradiation mutagenesis in genetically modified herbicide-tolerant Zoysia japonica", Breed Sci, 59, pp.103~105 (2009)
- Fullerton A, "Guidelines for measurement of skin colour and erythema. A report from the Standardization Group of the European Society of Contact Dermatitis", Contact Dermatitis, 35, pp.1~10 (1996)
- Zug KA, "Patch-test results of the North American Contact Dermatitis Group 2005-2006", Dermatitis, 20, pp.149~160 (2009)
- "ISAAA brief 43-2011: executive summary. Global status of commercialized biotech/GM crops: 2011" (2011)[URL]
- Goodman RE, "Allergenicity assessment of genetically modified crops: what makes sense?", Nat Biotechnol, 26, pp.73~81 (2008)
- Taylor SL, "Will genetically modified foods be allergenic?", J Allergy Clin Immunol, 107, pp.765~771 (2001)
- Herman EM, "Genetic modification removes an immunodominant allergen from soybean", Plant Physiol, 132, pp.36~43 (2003)
- The Korean Academy Asthma, Allergy, and Clinical Immunology, "Asthma and allergic diseases", pp.53~58 (2012), Ryo Moon Gak
- de Groot AC, "Kanerva's occupational dermatology", pp.1849~1893 (2012), Springer
- Nixon LR, "Middleton's Allergy: principles and practice", pp.565~574 (2013), Elsevier Health Sciences
- 이가영, "접촉피부염 환자에서의 첩포검사 결과에 대한 고찰- 최근 7년(2000∼2006)간 조사를 중심으로 -", 대한피부과학회지, 45(9), pp.908~914 (2007), 대한피부과학회
- Hansen SR, "Patch testing and nickel allergy", Tidsskr Nor Laegeforen, 128, pp.433~435 (2008)