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가족성 정신분열병 환자에서 임상 특성의 가족내 연관성

Intra-familial Correlations of Symptoms and Clinical Characteristics in Multiplex Korean Families with Schizophrenia

홍경수|김상욱|김창현|이유상|조은영|전현옥|장용이|최경숙
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.09|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제5호|pp. 529-536

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참고문헌

키워드

정신분열병 · 가족성 · 가족내 연관성.Schizophrenia · Multiplex families · Intra-familial corelation.
주제분류정신과학

초록

Objectives：This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods：Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ2-test and Spearman’s correlation. Results：Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoid subtype (χ2=7.623, p=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ2=3.850, p= 0.0497, df=1). Among single symptom items in DIGS, only ‘auditory hallucination’ showed significant concordance rate (χ2= 5.503, p=0.019, df=1). Factor analysis for symptoms items in the Krawiecka Rating Scale indicated three symptom dimensions； negative, psychotic and affective. Psychotic (ρ=0.442, p=0.003) and affective dimension scores (ρ=0.427, p=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion：Familial factors, possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-paranoid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome. It supports their use in the delineation of homogeneous subgroups for future genetic studies (J Korean Neuropsychiatr Assoc 2004;43(5):529-536)

Abstract

Objectives：This study aims at examining familial associations of symptoms and clinical characteristics in affected sibling or relative pairs of schizophrenia as an effort to identify genetically homogeneous phenotypes. Methods：Forty-seven relative pairs with DSM-IV diagnosis of schizophrenia from thirty-five Korean families multiply affected with schizophrenia were ascertained. Direct interviews were done using the Korean version of Diagnostic Interview for Genetic Studies (DIGS). The Krawieka Rating Scale and the Schedule for the Deficit Syndrome were also applied for further evaluation of psychopathologies. Intra-familial concordances and correlations of clinical characteristics and symptoms were tested using χ2-test and Spearman’s correlation. Results：Significantly high concordance rate within relative pairs was found for the diagnosis of paranoid vs. non-paranoid subtype (χ2=7.623, p=0.006, df=1). Deficit vs. non-deficit syndrome also showed significant concordance (χ2=3.850, p= 0.0497, df=1). Among single symptom items in DIGS, only ‘auditory hallucination’ showed significant concordance rate (χ2= 5.503, p=0.019, df=1). Factor analysis for symptoms items in the Krawiecka Rating Scale indicated three symptom dimensions； negative, psychotic and affective. Psychotic (ρ=0.442, p=0.003) and affective dimension scores (ρ=0.427, p=0.004) showed significant intra-familial correlations. Age at onset of recognized psychotic symptoms showed significant correlation only within the male sibling pairs. Conclusion：Familial factors, possibly genetic factor contribute to the phenotypic characteristics of paranoid vs. non-paranoid subtype, deficit vs. non-deficit syndrome, auditory hallucination, and affective syndrome. It supports their use in the delineation of homogeneous subgroups for future genetic studies (J Korean Neuropsychiatr Assoc 2004;43(5):529-536)

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