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양극성 장애와 Monocyte Chemoattractant Protein-1 유전자 다형성

Monocyte Chemoattrant Protein-1 (MCP-1) -2518 Polymorphism and Bipolar I Disorder

김정진|이수정|전태연|이철|장우영|김태석|이창욱|배치운|백인호
대한신경정신의학회 (Korean Neuropsychiatric Association)|2004.09|신경정신의학 (JOURNAL OF THE KOREAN NEUROPSYCHIATRIC ASSOCIATION)|제43권 제5호|pp. 524-528

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참고문헌

키워드

양극성 장애 · MCP1-2518 유전자 다형성.Bipolar disorder MCP1 promoter -2518 polymorphism.
주제분류정신과학

초록

Abstract

Objectives：Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD. Methods：Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain reaction-based method. Results：Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587； p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history (p=0.733) and psychotic feature (p=0.436) were not different between the two groups. Conclusion：Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and clinical diversity of the development of BD. (J Korean Neuropsychiatr Assoc 2004;43(5):524-528)

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